ARTICLES| VOLUME 399, ISSUE 10322, P384-392, JANUARY 22, 2022 An educational programme in neonatal intensive care units (SEPREVEN): a stepped-wedge, cluster-randomised controlled trial Laurence Caeymaex, Dominique Astruc, Valérie Biran, et al Lancet Published:January 22, 2022DOI:https://doi.org/10.1016/S0140-6736(21)01899-7 Summary Background Patients in neonatal intensive care units (NICUs) are at high risk of adverse events. The effects ...

Research Letter January 28, 2022 Frequency and Risk of Emergency Medical Service Interhospital Transportation of Patients With Acute Lower Respiratory Tract Illness During the COVID-19 Pandemic in the US Sadia H. Sarzynski, Alex Mancera, Clay Mann, et al JAMA. 2022;327(9):874-877. doi:10.1001/jama.2022.0812 Surges in hospital COVID-19 caseloads are detrimental to patients hospitalized with COVID-191 and other conditions.2 Transporting patients out of hosp...

Respiratory Management Strategies for AHRF Acute hypoxaemic respiratory failure (AHRF) is one of the most common causes of admission to the ICU. It has a mortality rate of nearly 30%. Non-invasive respiratory management strategies are recommended to avoid the risk of endotracheal intubation. However, patients with de novo acute hypoxaemic respiratory failure (AHRF) are often at high risk of treatment failure. De-novo AHRD refers to a condition that occurs without p...

ARTICLES|ONLINE FIRST A three-step support strategy for relatives of patients dying in the intensive care unit: a cluster randomised trial Nancy Kentish-Barnes, Sylvie Chevret, Sandrine Valade, et al Lancet Published:January 19, 2022DOI:https://doi.org/10.1016/S0140-6736(21)02176-0 Summary Background In relatives of patients dying in intensive care units (ICUs), inadequate team support can increase the prevalence of prolonged grief and other psychologica...

ICU Management & Practice, Volume 21 - Issue 6, 2021 CAR-T Cell Therapy – What An Intensivist Should Know CAR-T therapy is a promising treatment for B-cell malignancies but is also associated with toxicities such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). Frequent monitoring, timely recognition and prompt management in ICU are paramount to ensure good outcomes. Introduction Chimeric antigen r...

JAMA Clinical Guidelines Synopsis February 15, 2022 Diagnosis of Lyme Disease David Pitrak, Cynthia T. Nguyen, Adam S. Cifu, et al JAMA. 2022;327(7):676-677. doi:10.1001/jama.2022.0081 Guideline title Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease ...

Research SARS-CoV-2 vaccination and myocarditis or myopericarditis: population based cohort study Anders Husby, Jørgen Vinsløv Hansen, Emil Fosbøl, et al BMJ 2021; 375 doi: https://doi.org/10.1136/bmj-2021-068665 (Published 16 December 2021)Cite this as: BMJ 2021;375:e068665 Abstract Objective To investigate the association between SARS-CoV-2 vaccination and myocarditis or myopericarditis. Design Population based cohort study. Setting D...

ARTICLES|ONLINE FIRST Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study Tommy Nyberg, Neil M Ferguson, Sophie G Nash, et al Lancet Published:March 16, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)00462-7 Summary Background The omicron variant (B.1.1.529) of SARS-CoV-2 has demonstrated partial vaccine escape and high transmissibility,...

Original Investigation Caring for the Critically Ill PatientMarch 1, 2022 Association of Acute Respiratory Failure in Early Childhood With Long-term Neurocognitive Outcomes R. Scott Watson, Sue R. Beers, Lisa A. Asaro, et al JAMA. 2022;327(9):836-845. doi:10.1001/jama.2022.1480 Key Points Question  Do children with previously normal neurocognitive function who survive an episode of acute respiratory failure requiring intensive care ...

ICU Management & Practice, Volume 21 - Issue 6, 2021 The Importance of Accurate Glucose Monitoring in Critically Ill Patients The complexity of glucose testing, the limitations of point-of-care blood glucose monitoring systems and the need for accuracy and reliability to ensure optimised patient outcomes. Critically ill patients are not found just in intensive care units, but throughout the hospital: emergency departments, post-anaesthesia care units, op...