Editorial  Postoperative Transfusion in Patients at High Cardiac Risk: Evidence, Uncertainty, and Nuance Jeremy W. Jacobs, Evan M. Bloch JAMA Published Online: November 8, 2025 doi: 10.1001/jama.2025.21559 For 3 decades, randomized trials have provided evidence for and steadily moved practice toward restrictive red blood cell (RBC) transfusion strategies (ie, transfusing at hemoglobin thresholds of 7-8 g/dL instead of 9-10 g/dL).1-3 With rare exception...

Original Investigation  Caffeinated Coffee Consumption or Abstinence to Reduce Atrial Fibrillation: The DECAF Randomized Clinical Trial Christopher X. Wong, Christopher C. Cheung, Gabrielle Montenegro, et al JAMA Published Online: November 9, 2025 doi: 10.1001/jama.2025.21056 Key Points Question  Does consumption of caffeinated coffee have a beneficial, detrimental, or neutral effect on the risk...

Critical Care Ultrasonography in the Management of Cardiogenic Shock In ICU Wed, 20 Aug 2025 Despite recent advances, mortality in cardiogenic shock (CS) remains very high. Early diagnosis and proper management are crucial, especially given shifts in CS causes, from fewer myocardial ischaemia cases to more acute decompensated heart failure. The establishment of a consensus CS definition has improved clinical and research communication.  Critica...

ditorial  A-E-I-O-U and Sometimes Why—Dialysis in Acute Kidney Injury Sushrut S. Waikar JAMA Published Online: November 7, 2025 doi: 10.1001/jama.2025.21618 Students memorize the indications for dialysis in acute kidney injury (AKI) as the vowels of the alphabet, A-E-I-O-U: acidosis, electrolytes, ingestions, overload, and uremia. In a study published in JAMA, Liu and colleagues1 ask clinicians to consider the last vowel, sometimes Y (“why”), in their ...

Research Cause specific mortality risks associated with tropical cyclones in multiple countries and territories: two stage, time series study Wenzhong Huang, Rongbin Xu, Zhengyu Yang, et al BMJ 2025; 391 doi: https://doi.org/10.1136/bmj-2025-084906 (Published 05 November 2025)Cite this as: BMJ 2025;391:e084906 Abstract Objective To characterise and quantify the mortality risks for a range of causes after tropical cyclones in nine countries and territor...

Status Asthmaticus: The Art of Ventilating In ICU Thu, 24 Jul 2025 ICU Management & Practice, Volume 25 - Issue 3, 2025 Recognising the mechanisms of air trapping that cause status asthmaticus can help optimise the setting of invasive mechanical ventilation. This article provides an academic visual summary to facilitate understanding. Introduction Status asthmaticus can be life-threatening. Invasive mechanical ventilation is one of the therape...

Articles Global, regional, and national burden of chronic kidney disease in adults, 1990–2023, and its attributable risk factors: a systematic analysis for the Global Burden of Disease Study 2023 GBD 2023 Chronic Kidney Disease Collaborators Lancet 2025 Available online 7 November 2025 https://doi.org/10.1016/S0140-6736(25)01853-7 Summary Background Chronic kidney disease (CKD) is common and ranks among the leading causes of mortality and morbidity. T...

Original Investigation  Occupational Health Nurse Burnout and Patient Safety, Satisfaction, and Quality of Care: A Systematic Review and Meta-Analysis Lambert Zixin Li, Peilin Yang, Sara J. Singer, et al JAMA Netw Open 2024;7;(11):e2443059. doi:10.1001/jamanetworkopen.2024.43059 Key Points Question  What are the magnitude and moderators of the association between nurse burnout and health care quality and ...

ditorial  Divergent GFR Estimates and Clinical Implications Menaka Sarav, Robert J. Alpert JAMA Published Online: November 7, 2025 doi: 10.1001/jama.2025.14043 Chronic kidney disease (CKD) affects more than 800 million people worldwide, significantly increasing the risk for kidney failure, cardiovascular disease, and all-cause mortality.1 Accurate assessment of glomerular filtration rate (GFR) is essential for identifying and managing CKD. Although GFR...

Original Investigation  A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury: The Liberation From Acute Dialysis (LIBERATE-D) Randomized Clinical Trial Kathleen D. Liu, Edward D. Siew, Delphine S. Tuot, et al JAMA Published Online: November 7, 2025 doi: 10.1001/jama.2025.21530 Key Points Question  Can a conservative dialysis strategy improve rec...