Original Investigation  Transesophageal Echocardiography During CPR in Patients With Out-of-Hospital Cardiac Arrest: The EXECT-CPR Randomized Clinical Trial Sheng-En Chu, Chiao-Yin Cheng, Chih-Jung Chang, et al JAMA Intern Med Published Online: March 23, 2026 doi: 10.1001/jamainternmed.2026.0102 Key Points Question  Does transesophageal echocardiography (TEE)–guided cardiopulmonary resuscitation...

SPECIAL ARTICLE Society of Critical Care Medicine Guidelines on Caring for Older Adults in the ICU Ferrante, Lauren E.; Chaudhuri, Dipayan; Laiya Carayannopoulos, Kallirroi; et al Critical Care Medicine March 20, 2026 DOI: 10.1097/CCM.0000000000007085 Rationale:  Older adults (those 65 years old or greater) compose a substantial proportion of the ICU population. As older adults with critical illness possess unique factors and considerations relevant...

SPECIAL ARTICLE Society of Critical Care Medicine Guidelines for the Administration of Neuromuscular Blockade in Adults With Acute Respiratory Distress Syndrome Erstad, Brian L; Cobas, Miguel A; Qadir, Nida; et al Critical Care Medicine 54(3):p 634-643, March 2026. DOI: 10.1097/CCM.0000000000007002 Rationale:  Neuromuscular blocking agents (NMBAs) show potential benefits on mortality and other complications of acute respiratory distress syndrome (AR...

How Different Oximeters Affect Clinical Decision-Making In ICU Wed, 28 Jan 2026 An observational method comparison study examined whether different pulse oximetry devices provide consistent nocturnal oxygen saturation measurements in stable adults treated with continuous positive airway pressure (CPAP) or long-term noninvasive ventilation (NIV). Although overnight pulse oximetry is widely recommended to detect residual sleep-disordered breathing (SDB),...

Editorial  Surveillance of Sepsis in Children—Making Every Case Count Luregn J. Schlapbach, Shu-Ling Chong, Nora Luethi JAMA Published Online: March 22, 2026 doi: 10.1001/jama.2026.2814 Sepsis is a leading cause of hospital admissions, mortality, and health care expenditure worldwide. It disproportionally affects very young and very old individuals. Sepsis in young individuals carries a magnified societal impact through potential years of life lost and...

ARTICLE March 22, 2026 Procalcitonin testing combined with NEWS2 evaluation compared with usual care based on NEWS2 for identification of sepsis and antibiotic initiation in the emergency department in England and Wales (PRONTO): a multicentre, randomised, controlled, open-label, phase 3 trial Stacy Todd, Joanne Euden, Jennifer Condie, et al Lancet Respir Med Published March 22, 2026 DOI: 10.1016/S2213-2600(25)00433-3 Summary Background Sepsis is a co...

Original Investigation  Caring for the Critically Ill Patient National Estimates of Pediatric Sepsis in US Hospitals Using Clinical Data Chanu Rhee, Fran Balamuth, Kevin Dysart, et al JAMA Published Online: March 22, 2026 doi: 10.1001/jama.2026.3100 Key Points Question  What is the burden of nonneonatal pediatric sepsis in US hospitals using an electronic health record–based surveillance defi...

INSPIRE: Anakinra Treatment for Reducing Organ Dysfunction in Pneumonia  In ICU Wed, 28 Jan 2026 A recent article reports the INSPIRE trial, a study evaluating whether a precision immunotherapy strategy using the interleukin-1 (IL-1) receptor antagonist anakinra can prevent progression to organ dysfunction and death in adults hospitalised with community-acquired or hospital-acquired pneumonia who are identified as high risk by elevated presepsin l...

ARTICLES March 21, 2026Open Access Endotracheal surfactant for infants with life-threatening bronchiolitis (BESS): a randomised, blinded, sham-controlled, phase 2 trial Malcolm G Semple, Chloe Donohue, Laura Price, et al Lancet Respir Med Published March 21, 2026 DOI: 10.1016/S2213-2600(26)00008-1 Summary Background Bronchiolitis is a common viral respiratory disease of infants, with severity ranging from mild symptoms, such as coryza and feeding diff...

Targeted Tissue Perfusion vs Macrocirculatory-Guided Standard Care in Septic Shock In Sepsis Wed, 28 Jan 2026 The TARTARE-2S trial investigated whether a haemodynamic strategy focused on improving tissue perfusion while permitting lower-than-recommended mean arterial pressure (MAP) could improve outcomes in patients with septic shock compared with conventional MAP-guided standard care. Current sepsis guidelines prioritise maintaining MAP targets, typic...