Liberal or Restrictive Postoperative Transfusion in High-Risk Patients  In ICU Tue, 11 Nov 2025 Postoperative anaemia frequently occurs after major vascular or general surgical procedures and has been linked to an increased risk of short-term complications, especially in patients with pre-existing cardiovascular disease. While restrictive transfusion thresholds (haemoglobin < 7 g/dL) are generally considered safe for most hospitalised patients,...

Research Letter  Pediatrics Availability of Higher-Level Neonatal Care in Rural and Urban US Hospitals, 2010-2022 Katy B. Kozhimannil, Emily C. Sheffield, Clara E. Busse, et al JAMA Netw Open 2026;9;(2):e2559680. doi:10.1001/jamanetworkopen.2025.59680 Introduction Infant mortality is elevated for residents of rural US communities, in which access to childbirth care has been declining.1,2 Infants with high-acuity cl...

Persistent Opioid Use Among ICU Survivors After Discharge In ICU Tue, 11 Nov 2025 A recent study investigated the long-term continuation of opioid therapy among previously opioid-naïve patients following ICU treatment. Using a retrospective, nationwide cohort drawn from South Korea’s National Health Insurance Service (NHIS) database, the authors aimed to estimate the six-month incidence of new persistent opioid use and identify associated demographic, ...

Comment Testing early haemostatic therapy for acute intracerebral haemorrhage Craig S Anderson, Chen Chen, Rustam Al-Shahi Salman Lancet Available online 4 February 2026 https://doi.org/10.1016/S0140-6736(26)00146-7 The clinical severity, narrow time window to reduce bleeding, and variable care pathways for patients with spontaneous (non-traumatic) intracerebral haemorrhage (ICH) are enormous challenges to be overcome by treatments for this serious conditio...

Original Investigation  Critical Care Medicine Physician Variation in Early Sepsis Management Ithan D. Peltan, Danielle Groat, Jorie Butler, et al JAMA Netw Open 2026;9;(2):e2556945. doi:10.1001/jamanetworkopen.2025.56945 Key Points Question  Are sepsis treatment practice patterns characterized by faster antimicrobial initiation associated with increased overtreatment, and what are their mechanisms? Fi...

Article Health outcomes according to severity of acute kidney injury at ICU admission: a population-based cohort study Hundemer, G.L., Dumicho, A.Y., Knoll, G.A. et al. Intensive Care Med(2026). Published: 05 February 2026 https://doi.org/10.1007/s00134-026-08317-5 Abstract Purpose The presence and severity of acute kidney injury (AKI) upon ICU admission provides important short- and long-term prognostic information. Existing reports have been limited...

Positive Communication Programme Cuts ICU Staff Burnout  In ICU Sun, 9 Nov 2025 Burnout among intensive care unit (ICU) professionals remains a persistent concern, with earlier reports indicating levels approaching 60% in these settings. The Hello trial tested whether a pragmatic, unit-wide programme designed to support organisational culture and team climate could reduce burnout across a broad int...

Articles Recombinant factor VIIa versus placebo for spontaneous intracerebral haemorrhage within 2 h of symptom onset (FASTEST): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial Joseph P Broderick, Andrew M Naidech, Jordan J Elm, et al Lancet Available online 4 February 2026 https://doi.org/10.1016/S0140-6736(26)00097-8 Summary Background Recombinant factor VIIa has been shown to slow bleeding in patients with intracerebral h...

Article The comparison of circuit lifespan between integration and separation approach in extracorporeal membrane oxygenation patients requiring continuous renal replacement therapy support: a randomized controlled trial (E-CRRT Trial) Tangjitaree, P., Thanapongsatorn, P., Sinjira, T. et al. Intensive Care Med (2026). https://doi.org/10.1007/s00134-026-08302-y Abstract Background The estimated incidence of acute kidney injury requiring renal replacement ...

HUMANITIES: ORIGINAL RESEARCHVolume 169, Issue 2P486-495February 2026 Post-Intensive Care Syndrome Awareness and Communication: Surveys of ICU Providers and Patients Mark L. Rolfsen, Matthew F. Mart, Hannah Kieffer, et al Chest 2026; 169: 486-495 DOI: 10.1016/j.chest.2025.08.048 Abstract Background Survivors of critical illness often experience new or worsening impairments in various domains of health after discharge, collectively referred to as post-...