R2D2-ICU: Restrictive vs Liberal Physical Restraint Strategies In ICU Tue, 17 Mar 2026 Findings from the Restrictive Use of Restraints and Delirium Duration in ICU (R2D2-ICU) trial were presented at the 45th ISICEM in Brussels. The trial investigated whether a restrictive (low-use) versus liberal (high-use) wrist-strap physical restraint strategy improves outcomes in critically ill adults receiving invasive mechanical ventilation. Physical restraint...

Original Investigation  Efficacy and Safety of Digitalis Glycosides in Heart Failure: A Meta-Analysis Kevin Damman, Dirk J. van Veldhuisen, Johann Bauersachs, et al JAMA Published Online: May 10, 2026 doi: 10.1001/jama.2026.7886 Key Points Question  What are the effects of digitalis glycoside treatment on cardiovascular death and worsening heart failure (HF) events in patients with HF with mildl...

Invited Commentary  Health Informatics Limitations of Large Language Models in Clinical Diagnostic Reasoning Mickael Tordjman, Xueyan Mei JAMA Netw Open 2026;9;(4):e264014. doi:10.1001/jamanetworkopen.2026.4014 Large language models (LLMs) have rapidly gained an important role in multiple fields, including medicine. These widely available tools can enhance patient understanding, improve physician productivity, and provide encyclopedic knowledge on seve...

Original Investigation  Digoxin in Patients With Symptomatic Rheumatic Heart Disease: A Randomized Clinical Trial Ganesan Karthikeyan, Niveditha Devasenapathy, Arpita Ghosh, et al JAMA Published Online: May 10, 2026 doi: 10.1001/jama.2026.7335 Key Points Question  Does digoxin, compared with placebo, reduce the composite of all-cause death or new-onset or worsening heart failure in symptomatic r...

CORRESPONDENCE Reducing Bacterial Contamination of Blood Bags with a Double Knot Kathleen Selleng, Halima Ismail, Christian Kohler, et al N Engl J Med 2026;394:1865-1866 DOI: 10.1056/NEJMc2600589 TO THE EDITOR: Bacterial contamination of blood for transfusions poses a serious risk to patients, particularly in resource-limited settings.1 Blood centers in high-income nations use heat-sealed tubing to close blood bags after donation; however, these too...

Editorial  Prone Positioning in Viral Bronchiolitis—Back to the Back? Joseph G. Kohne, Susan R. Conway, Steven L. Shein JAMA 2026;336;(4):290-292. doi:10.1001/jama.2026.11742 Acute viral bronchiolitis is the most common diagnosis in US children’s hospitals, and respiratory failure is the costliest diagnosis across all pediatric acute care.1 Despite the prevalence of this condition and its impact on children, families, and health systems, evidence-based tr...

Invited Commentary  Emergency Medicine Is Poor Recognition of Out-of-Hospital Cardiac Arrest to Blame for Worse Rates of Survival at Night? Sarah M. Perman JAMA Netw Open 2026;9;(4):e269837. doi:10.1001/jamanetworkopen.2026.9837 Emergency care is a 24 hours-a-day, 7 days-a-week, and 365 days-a-year operation. Those of us in emergency medicine, prehospital medicine, and acute critical care staff departments and agencies care for any patient with...

ORIGINAL ARTICLE Left Ventricular Unloading in High-Risk Percutaneous Coronary Intervention Divaka Perera, Matthew Ryan, Saad M. Ezad, et al N Engl J Med 2026;394:1779-1789 DOI: 10.1056/NEJMoa2515704 Abstract BACKGROUND Complex percutaneous coronary intervention (PCI) in patients with severely impaired left ventricular function carries a high risk of death and complications. Whether percutaneous left ventricular unlo...

Global Mortality Patterns Shift as COVID-19 Recedes  In ICU Mon, 3 Nov 2025 Regular, comparable assessments of causes of death help set health priorities. Updated estimates now cover 292 causes across 204 countries and territories, plus 660 subnational locations, for each year from 1990 to 2023. The analysis combines death counts, rates and years of life lost (YLLs) and adds two intuitive measures: the probability of dying before age 70 ...

Original Investigation  Caring for the Critically Ill Patient Prone Positioning in Infants With Acute Bronchiolitis: The PROPOSITIS Randomized Clinical Trial Florent Baudin, Robin Pouyau, Fabien Subtil, et al JAMA 2026;336;(4):315-322. doi:10.1001/jama.2026.11078 Key Points Question  Does prone positioning reduce escalation of respiratory support in infants aged 6 months or younger with moderate to severe bronchiolitis receiving high-flow ...