Are All Opioids Equivalent? In ICU Thu, 19 Mar 2026 Opioids are widely used in ICU care, but they are not interchangeable. Differences in pharmacology between agents such as fentanyl, morphine, and hydromorphone become clinically important in critically ill patients, particularly in the presence of organ dysfunction, prolonged infusions, and ventilator management. Research by Hannah Wunsch presented @ISICEM highlights that opioid selection is...

Original Investigation  Coffee and Tea Intake, Dementia Risk, and Cognitive Function Yu Zhang, Yuxi Liu, Yanping Li, et al JAMA Published Online: February 9, 2026 doi: 10.1001/jama.2025.27259 Key Points Question  Is long-term intake of caffeinated and decaffeinated coffee associated with risk of dementia and cognitive outcomes? Findings  In this prospective cohort study of 131 821 i...

Non-Invasive Technologies in Clinical Use on the Rise – A New Guideline In ICU Mon, 10 Mar 2025 ICU Management & Practice, Volume 25 - Issue 1, 2025 New guideline from the German Society for Anesthesiology that addresses the intraoperative clinical application of haemodynamic monitoring in non-cardiac surgical patients. The Executive Board of the German Society for Anesthesiology recently adopted a new guideline that addresses the intraopera...

Original Research Article | Critical Care Large-scale proteomic profiling identifies distinct inflammatory phenotypes in acute respiratory distress syndrome: a multicentre, prospective cohort study Mengna Lin, Feixiang Xu, Yiyu Deng, et al European Respiratory Journal 2026 67(2): 2500933 DOI: https://doi.org/10.1183/13993003.00933-2025 Abstract Background Host responses during acute respiratory distress syndrome are highly heterogeneous, contributing ...

Original Investigation  Bed Capacity and Utilization at Hospitals With Trauma Centers Pawan Acharya, Kristan Staudenmayer, Molly P. Jarman, et al JAMA Surg Published Online: February 4, 2026 doi: 10.1001/jamasurg.2025.6406 Key Points Question  What is the current utilization and reserve capacity of the US hospitals to absorb a sustained surge in acute trauma care demand? Findings  T...

Original Investigation  Postoperative Sleep Dynamics Across Surgical Risk Using Wearable Device Technology Abdulaziz Elemosho, Odysseas P. Chatzipanagiotou, Meher Angez, et al JAMA Surg Published Online: February 4, 2026 doi: 10.1001/jamasurg.2025.6386 Key Points Question  How does surgical risk level affect postoperative sleep architecture, and what is the natural history of these changes acros...

LATEST ISSUE STANDARD OF CARE IN THE INTENSIVE CARE UNIT What's New in Intensive Care Ten ethical challenges in donation after circulatory death (DCD): a practical guide for intensivistsVergano, M., Metaxa, V. & Citerio, G. Narrative Review Bedside thoracic echography in ICU: new insights for acute circulatory and respiratory failureMuller, L., Volpicelli, G., Mongodi, S. et al. LATEST ARTICLES Original Dynamic driving pressure and clinical out...

Original Investigation  Surgery Direct Oral Anticoagulant Levels at Time of Elective Surgery Eleonora Camilleri, Payam Shahbabai, Mandana Rad, et al JAMA Netw Open 2026;9;(2):e2555875. doi:10.1001/jamanetworkopen.2025.55875 Key Points Question  What proportion of patients have elevated residual direct oral anticoagulant (DOAC) levels before an elective procedure when discontinuing treatment according to a...

ESICM Recommendations for Management of Very Old Patients In ICU Wed, 29 Oct 2025 Very old patients, defined as those aged 80 years or older, represent the fastest-growing cohort in intensive care units across many countries. This population is characterised by high prevalence of functional impairments, multiple comorbidities, frailty, and marked biological and functional heterogeneity between individuals. The absence of robust evidence for managing cr...

Original Investigation  Age-Adjusted D-Dimer Cutoff Levels to Rule Out Deep Vein Thrombosis Grégoire Le Gal, Helia Robert-Ebadi, Venkatesh Thiruganasambandamoorthy, et al JAMA 2026;335;(5):416-424. doi:10.1001/jama.2025.21561 Key Points Question  Does an age-adjusted D-dimer cutoff safely increase the proportion of patients in whom deep vein thrombosis (DVT) can be excluded? Findings  In this multina...