Comment Can better oral care reduce non-ventilator hospital-acquired pneumonia? Catia Cilloniz, Michael Klompas Lancet Infect Dis Available online 8 June 2026 https://doi.org/10.1016/S1473-3099(26)00282-3Get rights and content Non-ventilator hospital-acquired pneumonia (NV-HAP) is the most frequent and deadly health-care-associated infection.1, 2 The Hospital Acquired Pneumonia Prevention (HAPPEN) trial, presented by Nicole M White and colleagues in The Lan...

Articles Effectiveness of oral care for the prevention of non-ventilator hospital-acquired pneumonia (HAPPEN): a multicentre, stepped-wedge, cluster-randomised trial in Australia Nicole M White, Philip L Russo, Georgia Matterson, et al Lancet Infect Dis Available online 8 June 2026 https://doi.org/10.1016/S1473-3099(26)00235-5 Summary Background Non-ventilator hospital-acquired pneumonia (NV-HAP) is among the most prevalent health-care-associated infe...

ONLINE FIRST (FREE ACCESS) ARDS 60TH ANNIVERSARY Narrative Review Volatile anesthetic sedation in acute respiratory distress syndromeO’Gara, B., Boncyk, C., Müller Wirtz, L.M. et al. LATEST ARTICLES Scientific letter Determinants of neurologic causes and systemic causes of death in severe meningitis and encephalitis: insights from the international prospective multicenter EURECA studyGrospeaud, L., Sonneville, R., de Montmollin, E. et al. Corresponden...

Comment From PROSpect to the bedside: contextual and pathophysiological considerations Jeremy M Loberger, Robinder G Khemani Lancet 2026; 408: 1788-1789 https://doi.org/10.1016/S0140-6736(26)02054-4 Paediatric acute respiratory distress syndrome (PARDS) is a common, severe manifestation of direct or indirect lung injury in children. Management focuses on the careful implementation of lung protective strategies with high-frequency oscillatory ventilation (HF...

Articles Deramiocel heart-derived cellular therapy in advanced Duchenne muscular dystrophy (HOPE-3): a phase 3, randomised, double-blind, placebo-controlled trial Craig M McDonald, Chet Villa, Jonathan H Soslow, et al Lancet Available online 29 July 2026 https://doi.org/10.1016/S0140-6736(26)01385-1 Summary Background Duchenne muscular dystrophy (DMD) is an X-linked genetic disease of skeletal and cardiac muscle that leads to loss of ambulation and pr...

Articles Prone positioning and high-frequency oscillatory ventilation in early paediatric acute respiratory distress syndrome (PROSpect): an international, two-by-two factorial, response-adaptive, phase 3, randomised controlled trial Martha A Q Curley, Martin C J Kneyber, Ira M Cheifetz, et al Lancet 2026; 408: 1815-1827 https://doi.org/10.1016/S0140-6736(26)01949-5 Summary Background Data on prone positioning and high-frequency oscillatory ventilatio...

Original Investigation  Critical Care Medicine Diagnostic Stewardship of Respiratory Cultures Using Clinical Decision Support in the PICU Anna C. Sick-Samuels, Charlotte Z. Woods-Hill, Daniel P. Kelly, et al JAMA Netw Open 2026;9;(7):e2626547. doi:10.1001/jamanetworkopen.2026.26547 Key Points Question  What is the association of diagnostic stewardship of endotracheal aspirate cultures using clinical decis...

Original Investigation  Cardiology Restrictive vs Liberal Transfusion Strategy After Myocardial Infarction: A Post Hoc Analysis of the MINT Randomized Clinical Trial Marnie Bertolet, Francois Martin Carrier, Simone Glynn, et al JAMA Netw Open 2026;9;(7):e2624991. doi:10.1001/jamanetworkopen.2026.24991 Key Points Question  What is the posterior probability that a liberal vs restrictive transfusion strategy...

Original Investigation  Infectious Diseases World Health Organization Multimodal Improvement Strategy for Hand Hygiene: A Stepped-Wedge Cluster Randomized Trial Emma Nyawere, Hiroki Saito, Robinah Ajok, et al JAMA Netw Open 2026;9;(7):e2625250. doi:10.1001/jamanetworkopen.2026.25250 Key Points Question  What is the long-term impact of the World Health Organization (WHO) multimodal improvement strategy (MM...

Invited Commentary  Pediatrics Probiotic-Associated Infection vs Necrotizing Enterocolitis—Weighing Risks and Benefits Brian Scottoline, Brian K. Jordan JAMA Netw Open 2026;9;(7):e2626535. doi:10.1001/jamanetworkopen.2026.26535 To our knowledge, the report by Patel et al1 represents the largest effort to date to estimate the risk of probiotic-associated bloodstream infection in very preterm (VPT) infants (gestational age <32 weeks at birth). They ha...