ORIGINAL ARTICLE Protection against SARS-CoV-2 after Covid-19 Vaccination and Previous Infection Victoria Hall, Sarah Foulkes, Ferdinando Insalata, et al N Engl J Med 2022; 386:1207-1220DOI: 10.1056/NEJMoa2118691 Abstract BACKGROUND The duration and effectiveness of immunity from infection with and vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are relevant to pandemic policy interventions, including the timing of vaccin...

ARDS Subphenotypes Using Machine Learning An observational, multicohort, retrospective study was conducted to validate two machine-learning clinical classifier models for assigning acute respiratory distress syndrome (ARDS) subphenotypes. Two ARDS subphenotypes with distinct biological and clinical features and differential treatment responses have been identified in seven individual cohorts. In addition, clinical classifier models to facilitate bedside identi...

ORIGINAL ARTICLE Homologous and Heterologous Covid-19 Booster Vaccinations Robert L. Atmar, Kirsten E. Lyke, Meagan E. Deming, et al N Engl J Med January 26, 2022DOI: 10.1056/NEJMoa2116414 Abstract BACKGROUND Although the three vaccines against coronavirus disease 2019 (Covid-19) that have received emergency use authorization in the United States are highly effective, breakthrough infections are occurring. Data are needed on the serial use of homologous ...

Post-hoc Analysis of the NONSEDA Trial In recent years, there has been an increase in awareness of minimising sedation in the ICU. Several benefits of avoiding heavy sedation have been reported in clinical studies, and clinical guidelines also encourage less sedation. Findings from the NONSEDA trial were published in 2020. In this trial, 700 critically ill patients were randomised to receive light sedation or non-sedation during mechanical ventilation. Findings ...

Editorials Awake prone positioning for patients with covid-19 Joseph Barker, David Koeckerling, Nadeesha Lakmal Mudalige, et al BMJ 2022; 376 doi: https://doi.org/10.1136/bmj.o632 (Published 23 March 2022)Cite this as: BMJ 2022;376:o632 It’s a matter of time Awake prone positioning is thought to improve clinical outcomes in patients with covid-19 by modulating lung mechanics during progressive hypoxaemic respiratory failure.12 The intervention is attra...

CORRESPONDENCE Efficacy of Antibodies and Antiviral Drugs against Covid-19 Omicron Variant Emi Takashita, Noriko Kinoshita, Seiya Yamayoshi, et al N Engl J Med January 26, 2022DOI: 10.1056/NEJMc2119407 TO THE EDITOR: In November 2021, the B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was detected in South Africa.1 Since then, omicron has rapidly spread around the world. On November 26, 2021, the World Healt...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalSurvival benefit of extracorporeal membrane oxygenation in severe COVID-19: a multi-centre-matched cohort studyWhebell S. et al. Natural language processing diagnosed behavioral disturbance vs confusion assessment method for the intensive care unit: prevalence, patient characteristics, overlap, and association with treatment and outcomeYoung M. et al. OPEN ACCESS ~ Systematic ReviewPrediction of good neurologi...

ICU Management & Practice, Volume 21 - Issue 3, 2021 Diaphragm Ultrasonography in ICU: Why, How, and When To Use It? An overview of the principles and current applications of diaphragm ultrasound and innovative ultrasound-based techniques. Introduction  In the intensive care unit (ICU), ultrasound imaging has become increasingly popular for the diagnosis and to guide treatment in critically ill patients (Volpicelli et al. 2020). The use of ultras...

Research Prone positioning of patients with moderate hypoxaemia due to covid-19: multicentre pragmatic randomised trial (COVID-PRONE) Michael Fralick, Michael Colacci, Laveena Munshi, et al BMJ 2022; 376 doi: https://doi.org/10.1136/bmj-2021-068585 (Published 23 March 2022)Cite this as: BMJ 2022;376:e068585 Abstract Objectives To assess the effectiveness of prone positioning to reduce the risk of death or respiratory failure in non-critically ill patie...

CORRESPONDENCE Lung Transplantation for Covid-19–Related Respiratory Failure in the United States Amy Roach, Joanna Chikwe, Pedro Catarino N Engl J Med January 26, 2022DOI: 10.1056/NEJMc2117024 TO THE EDITOR: There are case reports of lung transplantation for respiratory failure due to coronavirus disease 2019 (Covid-19), but uncertainty surrounds patient selection, clinical outcomes, and the appropriateness of lung transplantation in this context.1-3 We th...