Editorial March 24, 2022 COVID-19 mRNA Vaccines During Pregnancy: New Evidence to Help Address Vaccine Hesitancy Elyse O. Kharbanda, Gabriela Vazquez-Benitez JAMA. 2022;327(15):1451-1453. doi:10.1001/jama.2022.2459 SARS-CoV-2 infection during pregnancy is associated with increased risk for maternal morbidity and adverse birth outcomes.1,2 COVID-19 vaccines are effective for preventing severe disease, including in pregnant populations.3 Although ...

ED Admission and Adherence to Surviving Sepsis Campaign Bundle Approximately 85,000 patients are admitted to the emergency department in the U.S. each year for sepsis or septic shock. The Surviving Sepsis Campaign (SSC) has established International clinical practice guidelines for managing these patients. The guidelines consist of a bundle that includes treatments for various components of sepsis, including rapid fluid resuscitation, administration of antibiotics,...

ARTICLES|ONLINE FIRST Screening and vaccination against COVID-19 to minimise school closure: a modelling study Elisabetta Colosi, Giulia Bassignana, Diego Andrés Contreras, et al Lancet Infect Dis Published:April 01, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00138-4 Summary Background Schools were closed extensively in 2020–21 to counter SARS-CoV-2 spread, impacting students' education and wellbeing. With highly contagious variants expanding in E...

Original Investigation Caring for the Critically Ill PatientFebruary 22, 2022 Effect of Intra-arrest Transport, Extracorporeal Cardiopulmonary Resuscitation, and Immediate Invasive Assessment and Treatment on Functional Neurologic Outcome in Refractory Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial Jan Belohlavek, Jana Smalcova, Daniel Rob, et al JAMA. 2022;327(8):737-747. doi:10.1001/jama.2022.1025 Key Points Question  ...

Original Investigation March 24, 2022 Association of COVID-19 Vaccination in Pregnancy With Adverse Peripartum Outcomes Deshayne B. Fell, Tavleen Dhinsa, Gillian D. Alton, et al JAMA. 2022;327(15):1478-1487. doi:10.1001/jama.2022.4255 Key Points Question  Is COVID-19 vaccination during pregnancy associated with adverse peripartum outcomes? Findings  In this population-based retrospective cohort study of 97 590 individuals in Onta...

ARTICLES| VOLUME 10, ISSUE 4, P355-366, APRIL 01, 2022 SARS-CoV-2 infection and vaccine effectiveness in England (REACT-1): a series of cross-sectional random community surveys Marc Chadeau-Hyam, Haowei Wang, Oliver Eales, et al Lancet Respir Med 2022; 10: 355-366 Summary Background England has experienced a third wave of the COVID-19 epidemic since the end of May, 2021, coinciding with the rapid spread of the delta (B.1.617.2) variant, de...

Compassionate Care in the ICU Over the years, there have been many advancements in the understanding of critical illness pathophysiology, technologies used to support failing organ systems, and improvements in communication and shared decision-making. In this review, the authors reflect on the role of compassion and openness of critical care clinicians when supporting patients, their families and ICU colleagues, especially when facing health or life-threatening ill...

Original Investigation March 24, 2022 Association of SARS-CoV-2 Vaccination During Pregnancy With Pregnancy Outcomes Maria C. Magnus, Anne K. Örtqvist, Elisabeth Dahlqwist, et al JAMA. 2022;327(15):1469-1477. doi:10.1001/jama.2022.3271 Key Points Questions  Is SARS-CoV-2 vaccination during pregnancy associated with adverse pregnancy outcomes? Findings  In this population-based retrospective cohort study that included 157 521 deli...

CORRESPONDENCE|ONLINE FIRST Antibody durability at 1 year after Sputnik V vaccination Lautaro Sanchez, Santiago Oviedo Rouco, Marina Pifano, et al Antibody waning against SARS-CoV-2 over time after vaccination, together with the emergence of new viral variants, pose great challenges for ending the pandemic. To our knowledge, no previous work has assessed the long-term prevalence of anti-SARS-CoV-2 antibodies in individuals vaccinated with Sputnik V (Gam-COVID-Vac...

Therapeutic Hyperthermia and Survival in Critically Ill Afebrile Sepsis Patients A major feature of infection is fever. However, less than half of critically ill patients with sepsis have a fever at the time of diagnosis. Afebrile patients with sepsis have nearly twice the mortality and are more likely to develop secondary infections than patients with fever. Fever is thus an adaptive response to the infection and is critical for survival. Studies have shown elevat...