ORIGINAL ARTICLE Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients Angélica Jayk Bernal, Monica M. Gomes da Silva, Dany B. Musungaie, et al N Engl J Med December 16, 2021DOI: 10.1056/NEJMoa2116044 Abstract BACKGROUND New treatments are needed to reduce the risk of progression of coronavirus disease 2019 (Covid-19). Molnupiravir is an oral, small-molecule antiviral prodrug that is active against severe acute respiratory syndrome coro...

CORRESPONDENCE Efficacy of Natural Immunity against SARS-CoV-2 Reinfection with the Beta Variant Hiam Chemaitelly, Roberto Bertollini, Laith J. Abu-Raddad N Engl J Med December 15, 2021DOI: 10.1056/NEJMc2110300 TO THE EDITOR: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) beta (B.1.351) variant of concern harbors mutations that can mediate immune evasion, and it appears to be less sensitive than the alpha (B.1.1.7) variant or wild-type vir...

Feature Christmas 2021: What a Wonderful World Just a smidge, or a bridge too far? Slang use in the ICU James M Hodgetts, Ayat Mohamed, Stephen Lewis BMJ 2021; 375 doi: https://doi.org/10.1136/bmj-2021-067900 (Published 16 December 2021)Cite this as: BMJ 2021;375:e067900 A shared lingo can create cohesion in “the unit,” but James M Hodgetts and colleaguesask whether this is exclusionary and puts patient safety at risk Towards the end of the second...

Research Christmas 2021: What a Wonderful World Association of Logic’s hip hop song “1-800-273-8255” with Lifeline calls and suicides in the United States: interrupted time series analysis Thomas Niederkrotenthaler, Ulrich S Tran, Madelyn Gould, et al BMJ 2021; 375 doi: https://doi.org/10.1136/bmj-2021-067726 (Published 13 December 2021)Cite this as: BMJ 2021;375:e067726 Abstract Objective To assess changes in daily call volumes to the US National...

Research Discordant and inappropriate discordant recommendations in consensus and evidence based guidelines: empirical analysis Liang Yao, Muhammad Muneeb Ahmed, Gordon H Guyatt, et al BMJ 2021; 375 doi: https://doi.org/10.1136/bmj-2021-066045 (Published 25 November 2021)Cite this as: BMJ 2021;375:e066045 Abstract Objective To investigate whether alignment of strength of recommendations with quality of evidence differs in consensus based versus evidenc...

Research Christmas 2021: Get Lucky Heavy metal toxicity and mortality—association between density of heavy metal bands and cause specific hospital admissions and mortality: population based cohort study Pekka Martikainen, Kaarina Korhonen, Lasse Tarkiainen BMJ 2021; 375 doi: https://doi.org/10.1136/bmj-2021-067633 (Published 15 December 2021)Cite this as: BMJ 2021;375:e067633 Abstract Objective To assess the association between area level density ...

Haemodynamic Monitoring and Management in Critical Care Over the last fifty years, haemodynamic monitoring techniques have progressed quite significantly, moving from bulky sphygmographs to invasive catheters to noninvasive digital monitors that provide continuous values of multiple haemodynamic variables. Haemodynamic monitoring concepts have also changed and have progressed from global macrohaemodynamic monitoring towards a more regional, microcirculatory perfusi...

Research Christmas 2021: What if . . .? “It’s not rocket science” and “It’s not brain surgery”—“It’s a walk in the park”: prospective comparative study Inga Usher, Peter Hellyer, Keng Siang Lee, et al BMJ 2021; 375 doi: https://doi.org/10.1136/bmj-2021-067883 (Published 13 December 2021)Cite this as: BMJ 2021;375:e067883 Abstract Objective To compare cognitive testing scores in neurosurgeons and aerospace engineers to help settle the age old argum...

Research Elapsed time since BNT162b2 vaccine and risk of SARS-CoV-2 infection: test negative design study Ariel Israel, Eugene Merzon, Alejandro A Schäffer, et al BMJ 2021; 375 doi: https://doi.org/10.1136/bmj-2021-067873 (Published 25 November 2021)Cite this as: BMJ 2021;375:e067873 Abstract Objectives To determine whether time elapsed since the second injection of the Pfizer-BioNTech BNT162b2 mRNA vaccine was significantly associated with the risk of...

Perioperative Dexmedetomidine and Postoperative Delirium Delirium is very common in patients who undergo major cardiac and non-cardiac surgery. Delirium is associated with postoperative mortality, postoperative cognitive dysfunction, increased length of stay in the hospital and postoperative complications and morbidity. A study was conducted to investigate the effect of perioperative administration of dexmedetomidine on the incidence of postoperative delirium in...