ICU Management & Practice, Volume 22 - Issue 2, 2022 Gastric Residual Volume – Monitoring and Management An overview of critical care guidelines for enteral nutrition (EN) and the use of gastric residual volume (GRV) management and monitoring as an essential component of EN patient care to help prevent complications. Malnutrition in Critically Ill and the Use of Enteral or Parenteral Nutrition Disease-related malnutrition is a common problem amon...

ARTICLES|ONLINE FIRST Severity of omicron variant of concern and effectiveness of vaccine boosters against symptomatic disease in Scotland (EAVE II): a national cohort study with nested test-negative design Aziz Sheikh, Steven Kerr, Mark Woolhouse, et al Lancet Infect Dis Published:April 22, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00141-4 Summary Background Since its emergence in November, 2021, in southern Africa, the SARS-CoV-2 omicron varian...

Research Letter April 8, 2022 Antibiotic Prescriptions Associated With COVID-19 Outpatient Visits Among Medicare Beneficiaries, April 2020 to April 2021 Sharon V. Tsay, Monina Bartoces, Katryna Gouin, et al JAMA. Published online April 8, 2022. doi:10.1001/jama.2022.5471 Antibiotics are ineffective treatment for viral syndromes, including COVID-19. We characterized antibiotic prescribing in older adults with outpatient COVID-19 visits to identif...

ARTICLES|ONLINE FIRST Awake prone positioning for non-intubated patients with COVID-19-related acute hypoxaemic respiratory failure: a systematic review and meta-analysis Jie Li, Jian Luo, Ivan Pavlov, et al Lancet Respir Med Published: March 16, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00043-1 Summary Background Awake prone positioning has been broadly utilised for non-intubated patients with COVID-19-related acute hypoxaemic respiratory failur...

ARTICLES| VOLUME 22, ISSUE 5, P611-621, MAY 01, 2022 Efficacy and safety of CD24Fc in hospitalised patients with COVID-19: a randomised, double-blind, placebo-controlled, phase 3 study James Welker, Juan D Pulido, Andrew T Catanzaro, et al Lancet Infect Dis 2022; 22: 611-621 Summary Background Non-antiviral therapeutic options are required for the treatment of hospitalised patients with COVID-19. CD24Fc is an immunomodulator with potential...

ARTICLES|ONLINE FIRST Algorithm-based care versus usual care for the early recognition and management of complications after pancreatic resection in the Netherlands: an open-label, nationwide, stepped-wedge cluster-randomised trial F Jasmijn Smits, Anne Claire Henry, Marc G Besselink, et al Lancet Published:April 28, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)00182-9 Summary Background Early recognition and management of postoperative complication...

CORRESPONDENCE| VOLUME 22, ISSUE 5, P588-589, MAY 01, 2022 Dynamics of humoral and T-cell immunity after three BNT162b2 vaccinations in adults older than 80 years Addi J Romero-Olmedo, Axel Ronald Schulz, Svenja Hochstätter, et al Lancet Infect Dis 2022; 22: 588-589 A third mRNA-based booster vaccination is the currently favoured strategy to maintain protection against SARS-CoV-2 infection. Yet, significant waning of specific immunity within 6 m...

ICU Management & Practice, Volume 22 - Issue 2, 2022 Septic Shock and Vasopressor Initiation: Why Earlier is Better An overview of vasopressor management, current evidence and when to initiate vasopressor therapy for best possible patient outcome. Vasopressor management is a cornerstone in the haemodynamic management of septic shock for reversing hypotension by increasing systemic vascular resistance and improving organ perfusion. The Surviving Sepsis Ca...

ORIGINAL ARTICLE Homologous and Heterologous Covid-19 Booster Vaccinations Robert L. Atmar, Kirsten E. Lyke, Meagan E. Deming, et al N Engl J Med 2022; 386:1046-1057DOI: 10.1056/NEJMoa2116414 Abstract BACKGROUND Although the three vaccines against coronavirus disease 2019 (Covid-19) that have received emergency use authorization in the United States are highly effective, breakthrough infections are occurring. Data are needed on the serial use of homologo...

ARTICLES|ONLINE FIRST A village doctor-led multifaceted intervention for blood pressure control in rural China: an open, cluster randomised trial Yingxian Sun, Jianjun Mu, Dao Wen Wang, et al. Lancet Published:April 29, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)00325-7 Summary Background The prevalence of uncontrolled hypertension is high and increasing in low-income and middle-income countries. We tested the effectiveness of a multifaceted inte...