Intravenous Vitamin C Administration for Septic Shock Sepsis is a life threatening condition with an estimated 49 million cases worldwide and 11 million deaths. It involves organ dysfunction due to a dysregulated host response to infection. Sepsis continues to be a global health issue and is is responsible for approximately 20% of annual global deaths.  Sepsis is typically managed through intravenous antibiotic therapy, source control of infection, fluid re...

COMMENT|ONLINE FIRST In-hospital mortality of patients with severe bloodstream infection: only the tip of the iceberg Mathias W Pletz, Stefan Hagel, Sebastian Weis Lancet Infect Dis Published:January 19, 2022 DOI:https://doi.org/10.1016/S1473-3099(21)00619-8 Many studies on severe infections use in-hospital mortality, 14-day mortality, or 30-day mortality, as classic endpoints. However, in the era of high-performance intensive care, these endpoints no longe...

ARTICLES|ONLINE FIRST Development and validation of BLOOMY prediction scores for 14-day and 6-month mortality in hospitalised adults with bloodstream infections: a multicentre, prospective, cohort study Evelina Tacconelli, Siri Göpel, Beryl P Gladstone, et al Lancet Infect Dis Published:January 19, 2022 DOI:https://doi.org/10.1016/S1473-3099(21)00587-9 Summary Background The burden of bloodstream infections remains high worldwide and cannot be confine...

ORIGINAL ARTICLE BNT162b2 Protection against the Omicron Variant in Children and Adolescents Ashley M. Price, Samantha M. Olson, Margaret M. Newhams, et al N Engl J Med March 30, 2022DOI: 10.1056/NEJMoa2202826 Abstract BACKGROUND Spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.529 (omicron) variant, which led to increased U.S. hospitalizations for coronavirus disease 2019 (Covid-19), generated concern about immune evasion...

Optimal Respiratory Support for COVID-19 Patients Non-invasive respiratory support is an essential part of critical care. Non-invasive ventilation and high-flow nasal oxygen (HFNO) are commonly used in patients with acute hypoxaemic respiratory failure. Non-invasive respiratory support can alleviate respiratory distress, improve oxygenation and reduce the need for invasive mechanical ventilation. It can also help reduce mortality by reducing the need for trachea...

ARTICLES| VOLUME 22, ISSUE 2, P274-283, FEBRUARY 01, 2022 Narrow-spectrum antibiotics for community-acquired pneumonia in Dutch adults (CAP-PACT): a cross-sectional, stepped-wedge, cluster-randomised, non-inferiority, antimicrobial stewardship intervention trial Valentijn A Schweitzer, Inger van Heijl, Wim G Boersma, et al Lancet Infect Dis 2022; 22: 274-283 Summary Background Adults hospitalised to a non-intensive care unit (ICU) ward wit...

ORIGINAL ARTICLE Rilzabrutinib, an Oral BTK Inhibitor, in Immune Thrombocytopenia David J. Kuter, Merlin Efraim, Jiri Mayer, et al N Engl J Med 2022; 386:1421-1431DOI: 10.1056/NEJMoa2110297 Abstract BACKGROUND Rilzabrutinib, an oral, reversible covalent inhibitor of Bruton’s tyrosine kinase, may increase platelet counts in patients with immune thrombocytopenia by means of dual mechanisms of action: decreased macrophage (Fcγ receptor)–mediated platelet de...

ORIGINAL ARTICLE Early Outpatient Treatment for Covid-19 with Convalescent Plasma David J. Sullivan, Kelly A. Gebo, Shmuel Shoham, et al N Engl J Med March 30, 2022DOI: 10.1056/NEJMoa2119657 Abstract BACKGROUND Polyclonal convalescent plasma may be obtained from donors who have recovered from coronavirus disease 2019 (Covid-19). The efficacy of this plasma in preventing serious complications in outpatients with recent-onset Covid-19 is uncertain. ...

Diagnosing Non-Convulsive Seizures in the ICU: Tackling the Top Challenges One clinical factor complicating the work of ICU physicians and nurses is the difficulty of diagnosing nonconvulsive status epilepticus (NCSE)—an invisible condition that must be managed aggressively to prevent lasting damage to the brain. Because the prevalence of NCSE among neurological patients can reach up to 60%, and because it becomes increasingly hard to manage the longer it goes untreate...

ARTICLES|ONLINE FIRST Proteomic biomarkers of progressive fibrosing interstitial lung disease: a multicentre cohort analysis Willis S Bowman, Chad A Newton, Angela L Linderholm, et al Lancet Respir Med Published:January 18, 2022 DOI:https://doi.org/10.1016/S2213-2600(21)00503-8 Summary Background Progressive fibrosing interstitial lung disease (ILD) is characterised by parenchymal scar formation, leading to high morbidity and mortality. The ability to...