Original Investigation May 5, 2022 Effect of Direct Transportation to Thrombectomy-Capable Center vs Local Stroke Center on Neurological Outcomes in Patients With Suspected Large-Vessel Occlusion Stroke in Nonurban Areas: The RACECAT Randomized Clinical Trial Natalia Pérez de la Ossa, Sònia Abilleira, Tudor G. Jovin, et al JAMA. 2022;327(18):1782-1794. doi:10.1001/jama.2022.4404 Key Points Question  In patients experiencing suspected large-ve...

Original Investigation March 22/29, 2022 Association of Neonatal Hypoglycemia With Academic Performance in Mid-Childhood Rajesh Shah, Darren W. T. Dai, Jane M. Alsweiler, et al JAMA. 2022;327(12):1158-1170. doi:10.1001/jama.2022.0992 Key Points Question  Among children born at risk of neonatal hypoglycemia, do those who experience hypoglycemia have worse academic performance in mid-childhood? Findings  In this prospecti...

ARTICLES|ONLINE FIRST Efficacy of 12-months oral itraconazole versus 6-months oral itraconazole to prevent relapses of chronic pulmonary aspergillosis: an open-label, randomised controlled trial in India Inderpaul S Sehgal, Sahajal Dhooria, Valliappan Muthu, et al Lancet Infect Dis Published:April 13, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00057-3 Summary Background Chronic pulmonary aspergillosis has a 5-year mortality of 50–80% globally, and...

Original Investigation  Caring for the Critically Ill Patient June 16, 2022 Effect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Therapy on Liberation From Respiratory Support in Acutely Ill Children Admitted to Pediatric Critical Care Units: A Randomized Clinical Trial Padmanabhan Ramnarayan, Alvin Richards-Belle, Laura Drikite, et al JAMA. Published online June 16, 2022. doi:10.1001/jama.2022.9615 Key Poi...

Research Letter February 11, 2022 Association of Homologous and Heterologous Vaccine Boosters With COVID-19 Incidence and Severity in Singapore Sharon Hui Xuan Tan, Rachael Pung, Lin-Fa Wang, et al JAMA. 2022;327(12):1181-1182. doi:10.1001/jama.2022.1922 Reports of waning antibody levels and breakthrough infections among vaccinated individuals1have prompted the recommendation for vaccine boosters to prevent SARS-CoV-2 infections. Despite more than 80% of ...

News News Analysis Covid-19: Stockpiling antivirals risks repeating Tamiflu mistakes, experts warn Gareth Iacobucci BMJ 2022; 377 doi: https://doi.org/10.1136/bmj.o1053 (Published 27 April 2022)Cite this as: BMJ 2022;377:o1053 The UK government has made a huge investment in antivirals to fight covid, but some experts are concerned the waste and overspending of the 2000s will recur. Gareth Iacobucci reports The government’s Antivirals Taskforc...

ORIGINAL ARTICLE Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit François Lamontagne, Marie-Hélène Masse, Julie Menard, et al N Engl J Med June 15, 2022DOI: 10.1056/NEJMoa2200644 Abstract BACKGROUND Studies that have evaluated the use of intravenous vitamin C in adults with sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) have shown mixed results with respect to the risk of death and organ dysfunction....

ARTICLES|ONLINE FIRST Risk of hospitalisation associated with infection with SARS-CoV-2 omicron variant versus delta variant in Denmark: an observational cohort study Peter Bager, Jan Wohlfahrt, Samir Bhatt, et al Lancet Infect Dis Published:April 22, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00154-2 Summary Background Estimates of the severity of the SARS-CoV-2 omicron variant (B.1.1.529) are crucial to assess the public health impact associated...

Research Clinical severity of, and effectiveness of mRNA vaccines against, covid-19 from omicron, delta, and alpha SARS-CoV-2 variants in the United States: prospective observational study Adam S Lauring, Mark W Tenforde, James D Chappell, et al BMJ 2022; 376 doi: https://doi.org/10.1136/bmj-2021-069761 (Published 09 March 2022)Cite this as: BMJ 2022;376:e069761 Abstract Objectives To characterize the clinical severity of covid-19 associated with the a...

Article Monitoring SARS-CoV-2 in air and on surfaces and estimating infection risk in buildings and buses on a university campus Xin Zhang, Jianfeng Wu, Lauren M. Smith, et al J Expo Sci Environ Epidemiol (2022). 27 April 2022 https://doi.org/10.1038/s41370-022-00442-9 Abstract Background Evidence is needed on the presence of SARS-CoV-2 in various types of environmental samples and on the estimated transmission risks in non-healthcare settings on camp...