Compassionate Care in the ICU Over the years, there have been many advancements in the understanding of critical illness pathophysiology, technologies used to support failing organ systems, and improvements in communication and shared decision-making. In this review, the authors reflect on the role of compassion and openness of critical care clinicians when supporting patients, their families and ICU colleagues, especially when facing health or life-threatening ill...

Original Investigation March 24, 2022 Association of SARS-CoV-2 Vaccination During Pregnancy With Pregnancy Outcomes Maria C. Magnus, Anne K. Örtqvist, Elisabeth Dahlqwist, et al JAMA. 2022;327(15):1469-1477. doi:10.1001/jama.2022.3271 Key Points Questions  Is SARS-CoV-2 vaccination during pregnancy associated with adverse pregnancy outcomes? Findings  In this population-based retrospective cohort study that included 157 521 deli...

CORRESPONDENCE|ONLINE FIRST Antibody durability at 1 year after Sputnik V vaccination Lautaro Sanchez, Santiago Oviedo Rouco, Marina Pifano, et al Antibody waning against SARS-CoV-2 over time after vaccination, together with the emergence of new viral variants, pose great challenges for ending the pandemic. To our knowledge, no previous work has assessed the long-term prevalence of anti-SARS-CoV-2 antibodies in individuals vaccinated with Sputnik V (Gam-COVID-Vac...

Therapeutic Hyperthermia and Survival in Critically Ill Afebrile Sepsis Patients A major feature of infection is fever. However, less than half of critically ill patients with sepsis have a fever at the time of diagnosis. Afebrile patients with sepsis have nearly twice the mortality and are more likely to develop secondary infections than patients with fever. Fever is thus an adaptive response to the infection and is critical for survival. Studies have shown elevat...

Preliminary Communication February 10, 2022 Effect of Intra-arterial Alteplase vs Placebo Following Successful Thrombectomy on Functional Outcomes in Patients With Large Vessel Occlusion Acute Ischemic Stroke: The CHOICE Randomized Clinical Trial Arturo Renú, Mónica Millán, Luis San Román, et al JAMA. Published online February 10, 2022. doi:10.1001/jama.2022.1645 Key Points Question  Does the use of adjunct intra-arterial thrombolys...

Research Risk of adverse events after covid-19 in Danish children and adolescents and effectiveness of BNT162b2 in adolescents: cohort study Helene Kildegaard, Lars Christian Lund, Mikkel Højlund, et al BMJ 2022; 377 doi: https://doi.org/10.1136/bmj-2021-068898 (Published 11 April 2022)Cite this as: BMJ 2022;377:e068898 Abstract Objectives To assess the risk of acute and post-acute adverse events after SARS-CoV-2 infection in children and adolescents i...

ARTICLES|ONLINE FIRST Effectiveness of CoronaVac, ChAdOx1 nCoV-19, BNT162b2, and Ad26.COV2.S among individuals with previous SARS-CoV-2 infection in Brazil: a test-negative, case-control study Thiago Cerqueira-Silva, Jason R Andrews, Viviane S Boaventura, et al Lancet Infect Dis Published:March 31, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00140-2 Summary Background COVID-19 vaccines have proven highly effective among individuals without a previo...

Research App based education programme to reduce salt intake (AppSalt) in schoolchildren and their families in China: parallel, cluster randomised controlled trial Feng J He,  Puhong Zhang, Rong Luo, et al BMJ 2022; 376 doi: https://doi.org/10.1136/bmj-2021-066982 (Published 10 February 2022)Cite this as: BMJ 2022;376:e066982 Abstract Objective To determine whether a smartphone application based education programme can lower salt intake in schoolchildr...

ARTICLES|ONLINE FIRST Risk of SARS-CoV-2 reinfection and COVID-19 hospitalisation in individuals with natural and hybrid immunity: a retrospective, total population cohort study in Sweden Peter Nordström, Marcel Ballin, Anna Nordström Lancet Infect Dis Published:March 31, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00143-8 Summary Background Real-world evidence supporting vaccination against COVID-19 in individuals who have recovered from a previou...

ERC-ESICM Guidelines on Temperature Control After Cardiac Arrest The European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) have released new guidelines on temperature control after cardiac arrest in adults. The term Targeted Temperature Management (TTM) is used to describe temperature control after cardiac arrest. However, recently the Advanced Life Support (ALS) Task Force of the International Lisbon Committee on Resus...