Original Investigation  June 27, 2022 Temporal Trends in Antimicrobial Prescribing During Hospitalization for Potential Infection and Sepsis Hallie C. Prescott, Sarah Seelye, Xiao Qing Wang, et al JAMA Intern Med. Published online June 27, 2022. doi:10.1001/jamainternmed.2022.2291 Key Points Question  Is shortening the time to treatment for sepsis associated with increasing antimicrobial use, days of therapy, and broadness of cov...

Articles Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial Urs Fischer, Johannes Kaesmacher, Daniel Strbian, et al Lancet 2022; 400: 104-115 Summary Background Whether thrombectomy alone is equally as effective as intravenous alteplase plus thrombectomy remains controversial. We aimed to determine whether thrombectomy alone would ...

Articles Endovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4·5 h of stroke onset: an open-label, blinded-endpoint, randomised non-inferiority trial Peter J Mitchell, Bernard Yan, Leonid Churilov, et al Lancet 2022; 400: 116-125 https://doi.org/10.1016/S0140-6736(22)00564-5 Summary Background The benefit of combined treatment with intravenous thrombolysis before endovascular thrombectom...

CORRESPONDENCE Omicron SARS-CoV-2 Neutralization from Inactivated and ZF2001 Vaccines Xin Zhao, Rong Zhang, Shitong Qiao, et al N Engl J Med July 6, 2022DOI: 10.1056/NEJMc2206900 TO THE EDITOR: In the third year of the coronavirus disease 2019 (Covid-19) pandemic, the omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has swept the globe and yielded several subvariants.1,2 Currently, BA.2 is overtaking BA.1 in frequency. In addi...

Research Long distance airborne transmission of SARS-CoV-2: rapid systematic review Daphne Duval, Jennifer C Palmer, Isobel Tudge, et al BMJ 2022; 377 doi: https://doi.org/10.1136/bmj-2021-068743 (Published 29 June 2022)Cite this as: BMJ 2022;377:e068743 Abstract Objectives To evaluate the potential for long distance airborne transmission of SARS-CoV-2 in indoor community settings and to investigate factors that might influence transmission. Design&...

CORRESPONDENCE Duration of Shedding of Culturable Virus in SARS-CoV-2 Omicron (BA.1) Infection Julie Boucau, Caitlin Marino, James Regan, et al N Engl J Med June 29, 2022DOI: 10.1056/NEJMc2202092 TO THE EDITOR: The B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a shorter incubation period and a higher transmission rate than previous variants.1,2 Recently, the Centers for Disease Control and Prevention re...

ARTICLES|ONLINE FIRST Outcomes of flucytosine-containing combination treatment for cryptococcal meningitis in a South African national access programme: a cross-sectional observational study Rudzani C Mashau, Susan T Meiring, Vanessa C Quan, et al Lancet Infect Dis Published:June 21, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00234-1 Summary Background Although flucytosine is a key component of WHO-recommended induction treatment for HIV-asso...

Research Letter  June 24, 2022 Olfactory Dysfunction in Patients With Mild COVID-19 During Gamma, Delta, and Omicron Waves in Rio de Janeiro, Brazil Cynthia Chester Cardoso, Átila Duque Rossi, Rafael Mello Galliez, et al JAMA. Published online June 24, 2022. doi:10.1001/jama.2022.11006 Olfactory dysfunction is a common symptom of COVID-19, with reported rates as high as 70%. This symptom can be associated with mild COVID-19, mostly occurs wit...

Original Investigation  Caring for the Critically Ill Patient June 27, 2022 Effect of Nitric Oxide via Cardiopulmonary Bypass on Ventilator-Free Days in Young Children Undergoing Congenital Heart Disease Surgery: The NITRIC Randomized Clinical Trial Luregn J. Schlapbach, Kristen S. Gibbons, Stephen B. Horton, et al JAMA. Published online June 27, 2022. doi:10.1001/jama.2022.9376 Key Points Question  Does nitric oxide applied i...

Editorials Politics and mortality in the United States Steven Woolf BMJ 2022; 377 doi: https://doi.org/10.1136/bmj.o1308 (Published 07 June 2022)Cite this as: BMJ 2022;377:o1308 Mounting evidence suggests a link between republican politics and higher death rates For decades, people in the US have experienced lower life expectancy and poorer health outcomes than populations in other high income countries, and the problem has worsened over time.1 This pe...