Research Letter April 8, 2022 Systemic Corticosteroid Use for COVID-19 in US Outpatient Settings From April 2020 to August 2021 Marie C. Bradley, Silvia Perez-Vilar, Yoganand Chillarige, et al JAMA. Published online April 8, 2022. doi:10.1001/jama.2022.4877 In June 2020, preliminary results for the Randomised Evaluation of COVID-19 Therapy (RECOVERY) trial conducted in the UK indicated benefit from dexamethasone in severely ill hospitalized pati...

COMMENT| VOLUME 10, ISSUE 4, P314-315, APRIL 01, 2022 Baricitinib for patients with severe COVID-19—time to change the standard of care? Alexander Supady, Robert Zeiser Lancet Respir Med 2022; 10: 314-315 Mortality is high among patients with severe COVID-19 who require invasive mechanical ventilation (IMV) or extracorporeal membrane oxygenation (ECMO).1, 2 Therefore, further specific treatment options for these patients are urgently needed. ...

ICU Management & Practice, Volume 22 - Issue 1, 2022 Patient Safety in the ICU: Exploring Trends in Adverse Events in ICUs Adverse events (AEs) are common among critically ill patients. Evidence about the nature, preventability and predictability of AEs can be used to reinvest in efforts to reduce them and improve patient safety in ICUs. Case Mr. A, a previously well 70-year-old male was admitted to the intensive care unit (ICU) with respiratory failu...

Original Investigation Caring for the Critically Ill PatientFebruary 18, 2022 Association of COVID-19 Acute Respiratory Distress Syndrome With Symptoms of Posttraumatic Stress Disorder in Family Members After ICU Discharge Elie Azoulay, Matthieu Resche-Rigon, Bruno Megarbane, et al JAMA. Published online February 18, 2022. doi:10.1001/jama.2022.2017 Key Points Question  Is the risk of posttraumatic stress disorder (PTSD) symptoms in...

Editorial March 24, 2022 COVID-19 mRNA Vaccines During Pregnancy: New Evidence to Help Address Vaccine Hesitancy Elyse O. Kharbanda, Gabriela Vazquez-Benitez JAMA. 2022;327(15):1451-1453. doi:10.1001/jama.2022.2459 SARS-CoV-2 infection during pregnancy is associated with increased risk for maternal morbidity and adverse birth outcomes.1,2 COVID-19 vaccines are effective for preventing severe disease, including in pregnant populations.3 Although ...

ED Admission and Adherence to Surviving Sepsis Campaign Bundle Approximately 85,000 patients are admitted to the emergency department in the U.S. each year for sepsis or septic shock. The Surviving Sepsis Campaign (SSC) has established International clinical practice guidelines for managing these patients. The guidelines consist of a bundle that includes treatments for various components of sepsis, including rapid fluid resuscitation, administration of antibiotics,...

ARTICLES|ONLINE FIRST Screening and vaccination against COVID-19 to minimise school closure: a modelling study Elisabetta Colosi, Giulia Bassignana, Diego Andrés Contreras, et al Lancet Infect Dis Published:April 01, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00138-4 Summary Background Schools were closed extensively in 2020–21 to counter SARS-CoV-2 spread, impacting students' education and wellbeing. With highly contagious variants expanding in E...

Original Investigation Caring for the Critically Ill PatientFebruary 22, 2022 Effect of Intra-arrest Transport, Extracorporeal Cardiopulmonary Resuscitation, and Immediate Invasive Assessment and Treatment on Functional Neurologic Outcome in Refractory Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial Jan Belohlavek, Jana Smalcova, Daniel Rob, et al JAMA. 2022;327(8):737-747. doi:10.1001/jama.2022.1025 Key Points Question  ...

Original Investigation March 24, 2022 Association of COVID-19 Vaccination in Pregnancy With Adverse Peripartum Outcomes Deshayne B. Fell, Tavleen Dhinsa, Gillian D. Alton, et al JAMA. 2022;327(15):1478-1487. doi:10.1001/jama.2022.4255 Key Points Question  Is COVID-19 vaccination during pregnancy associated with adverse peripartum outcomes? Findings  In this population-based retrospective cohort study of 97 590 individuals in Onta...

ARTICLES| VOLUME 10, ISSUE 4, P355-366, APRIL 01, 2022 SARS-CoV-2 infection and vaccine effectiveness in England (REACT-1): a series of cross-sectional random community surveys Marc Chadeau-Hyam, Haowei Wang, Oliver Eales, et al Lancet Respir Med 2022; 10: 355-366 Summary Background England has experienced a third wave of the COVID-19 epidemic since the end of May, 2021, coinciding with the rapid spread of the delta (B.1.617.2) variant, de...