Viewpoint February 11, 2022 Time to Retire the Concept of Transient Ischemic Attack J. Donald Easton, S. Claiborne Johnston JAMA. 2022;327(9):813-814. doi:10.1001/jama.2022.0300 Transient ischemic attack (TIA) has been a useful clinical term even though agreement on the diagnosis for individual cases has been far from perfect even among experts.1 The utility of the diagnosis has waned with improvements in brain imaging and a deeper understa...

Ventilator-Associated Pneumonia in Patients With COVID-19 A major challenge in ICUs even before the COVID-19 pandemic was ventilator-associated pneumonia (VAP). However, now that the ICUs are even more overwhelmed with the complex and prolonged acute care of patients with COVID-19, VAP has become an even bigger issue. It has an overall incidence of 40 to 60%, but the problem is that the variation on VAP definitions used in different countries makes it very difficul...

ARTICLES| VOLUME 399, ISSUE 10322, P384-392, JANUARY 22, 2022 An educational programme in neonatal intensive care units (SEPREVEN): a stepped-wedge, cluster-randomised controlled trial Laurence Caeymaex, Dominique Astruc, Valérie Biran, et al Lancet Published:January 22, 2022DOI:https://doi.org/10.1016/S0140-6736(21)01899-7 Summary Background Patients in neonatal intensive care units (NICUs) are at high risk of adverse events. The effects ...

Research Letter January 28, 2022 Frequency and Risk of Emergency Medical Service Interhospital Transportation of Patients With Acute Lower Respiratory Tract Illness During the COVID-19 Pandemic in the US Sadia H. Sarzynski, Alex Mancera, Clay Mann, et al JAMA. 2022;327(9):874-877. doi:10.1001/jama.2022.0812 Surges in hospital COVID-19 caseloads are detrimental to patients hospitalized with COVID-191 and other conditions.2 Transporting patients out of hosp...

Respiratory Management Strategies for AHRF Acute hypoxaemic respiratory failure (AHRF) is one of the most common causes of admission to the ICU. It has a mortality rate of nearly 30%. Non-invasive respiratory management strategies are recommended to avoid the risk of endotracheal intubation. However, patients with de novo acute hypoxaemic respiratory failure (AHRF) are often at high risk of treatment failure. De-novo AHRD refers to a condition that occurs without p...

ARTICLES|ONLINE FIRST A three-step support strategy for relatives of patients dying in the intensive care unit: a cluster randomised trial Nancy Kentish-Barnes, Sylvie Chevret, Sandrine Valade, et al Lancet Published:January 19, 2022DOI:https://doi.org/10.1016/S0140-6736(21)02176-0 Summary Background In relatives of patients dying in intensive care units (ICUs), inadequate team support can increase the prevalence of prolonged grief and other psychologica...

ICU Management & Practice, Volume 21 - Issue 6, 2021 CAR-T Cell Therapy – What An Intensivist Should Know CAR-T therapy is a promising treatment for B-cell malignancies but is also associated with toxicities such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). Frequent monitoring, timely recognition and prompt management in ICU are paramount to ensure good outcomes. Introduction Chimeric antigen r...

JAMA Clinical Guidelines Synopsis February 15, 2022 Diagnosis of Lyme Disease David Pitrak, Cynthia T. Nguyen, Adam S. Cifu, et al JAMA. 2022;327(7):676-677. doi:10.1001/jama.2022.0081 Guideline title Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease ...

Research SARS-CoV-2 vaccination and myocarditis or myopericarditis: population based cohort study Anders Husby, Jørgen Vinsløv Hansen, Emil Fosbøl, et al BMJ 2021; 375 doi: https://doi.org/10.1136/bmj-2021-068665 (Published 16 December 2021)Cite this as: BMJ 2021;375:e068665 Abstract Objective To investigate the association between SARS-CoV-2 vaccination and myocarditis or myopericarditis. Design Population based cohort study. Setting D...

ARTICLES|ONLINE FIRST Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study Tommy Nyberg, Neil M Ferguson, Sophie G Nash, et al Lancet Published:March 16, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)00462-7 Summary Background The omicron variant (B.1.1.529) of SARS-CoV-2 has demonstrated partial vaccine escape and high transmissibility,...