Findings from the SAMDS-ICU Survey Pain is one of the most distressful symptoms among critically ill patients, along with shortness of breath and delirium. Pain is reported by 38 to 51% of patients at risk of dying. Delirium is highly prevalent among patients who are critically ill and is associated with worse short-term and long-term outcomes, including in-hospital mortality, longer duration of mechanical ventilation, longer stay in the hospital and the ICU and co...

ARTICLES| VOLUME 22, ISSUE 4, P483-495, APRIL 01, 2022 Immunogenicity and safety of a third dose of CoronaVac, and immune persistence of a two-dose schedule, in healthy adults: interim results from two single-centre, double-blind, randomised, placebo-controlled phase 2 clinical trials Gang Zeng, Qianhui Wu, Hongxing Pan, et al Lancet Infect Dis 2022; 22: 483-495 Summary Background Large-scale vaccination against COVID-19 is being implement...

ARTICLES| VOLUME 399, ISSUE 10335, P1618-1624, APRIL 23, 2022 Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from the ZOE COVID Study Cristina Menni, Ana M Valdes, Lorenzo Polidori, et al Lancet 2022; 399: 1618-1624 Summary Background The SARS-CoV-2 variant of concern, omicron, appears to be less se...

Critical Care Surge Response During COVID-19 In 2014, a consensus statement was published on mass critical care during public health emergencies. Over the last two years, the COVID-19 pandemic has highlighted gaps in prior pandemic planning and the need for modification based on experiences acquired during the surges of COVID-19 throughout the world. A subcommittee from the Task Force for Mass Critical Care (TFMCC) investigated the recent COVID-19 publications a...

COMMENT|ONLINE FIRST Severe influenza: is there a role for antiviral combinations? Siddharth Sridhar, Kelvin Kai-Wang To Lancet Infect Dis Published:January 24, 2022 DOI:https://doi.org/10.1016/S1473-3099(21)00484-9 Neuraminidase inhibitors have been approved for over 20 years and are currently the standard of care for the treatment of influenza. However, meta-analyses have shown only modest benefit of neuraminidase inhibitors for influenza.1, 2 N...

RESCUE-IHCA Mortality Prediction Score for IHCA A new study aimed to develop and validate a score to accurately predict the probability of death for adult extracorporeal cardiopulmonary resuscitation (ECPR). ECPR is widely used as a rescue technique among patients with refractory cardiac arrest and in patients with in-hospital cardiac arrest (IHCA) and out-of-hospital cardiac arrest (OHCA). ECPR has also been shown to improve survival and produce good neurological ...

ARTICLES|ONLINE FIRST Combining baloxavir marboxil with standard-of-care neuraminidase inhibitor in patients hospitalised with severe influenza (FLAGSTONE): a randomised, parallel-group, double-blind, placebo-controlled, superiority trial Deepali Kumar, Michael G Ison, Jean-Paul Mira, et al Lancet Infect Dis Published:January 24, 2022 DOI:https://doi.org/10.1016/S1473-3099(21)00469-2 Summary Background Neuraminidase inhibitors (NAIs) are considered th...

ORIGINAL ARTICLE Fourth Dose of BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting Ori Magen, Jacob G. Waxman, Maya Makov-Assif, et al N Engl J Med April 13, 2022DOI: 10.1056/NEJMoa2201688 Abstract BACKGROUND With large waves of infection driven by the B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), alongside evidence of waning immunity after the booster dose of coronavirus disease 2019 (Covid-19) vaccine,...

Intravenous Vitamin C Administration for Septic Shock Sepsis is a life threatening condition with an estimated 49 million cases worldwide and 11 million deaths. It involves organ dysfunction due to a dysregulated host response to infection. Sepsis continues to be a global health issue and is is responsible for approximately 20% of annual global deaths.  Sepsis is typically managed through intravenous antibiotic therapy, source control of infection, fluid re...

COMMENT|ONLINE FIRST In-hospital mortality of patients with severe bloodstream infection: only the tip of the iceberg Mathias W Pletz, Stefan Hagel, Sebastian Weis Lancet Infect Dis Published:January 19, 2022 DOI:https://doi.org/10.1016/S1473-3099(21)00619-8 Many studies on severe infections use in-hospital mortality, 14-day mortality, or 30-day mortality, as classic endpoints. However, in the era of high-performance intensive care, these endpoints no longe...