Articles Endovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4·5 h of stroke onset: an open-label, blinded-endpoint, randomised non-inferiority trial Peter J Mitchell, Bernard Yan, Leonid Churilov, et al Lancet 2022; 400: 116-125 https://doi.org/10.1016/S0140-6736(22)00564-5 Summary Background The benefit of combined treatment with intravenous thrombolysis before endovascular thrombectom...

CORRESPONDENCE Omicron SARS-CoV-2 Neutralization from Inactivated and ZF2001 Vaccines Xin Zhao, Rong Zhang, Shitong Qiao, et al N Engl J Med July 6, 2022DOI: 10.1056/NEJMc2206900 TO THE EDITOR: In the third year of the coronavirus disease 2019 (Covid-19) pandemic, the omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has swept the globe and yielded several subvariants.1,2 Currently, BA.2 is overtaking BA.1 in frequency. In addi...

Research Long distance airborne transmission of SARS-CoV-2: rapid systematic review Daphne Duval, Jennifer C Palmer, Isobel Tudge, et al BMJ 2022; 377 doi: https://doi.org/10.1136/bmj-2021-068743 (Published 29 June 2022)Cite this as: BMJ 2022;377:e068743 Abstract Objectives To evaluate the potential for long distance airborne transmission of SARS-CoV-2 in indoor community settings and to investigate factors that might influence transmission. Design&...

CORRESPONDENCE Duration of Shedding of Culturable Virus in SARS-CoV-2 Omicron (BA.1) Infection Julie Boucau, Caitlin Marino, James Regan, et al N Engl J Med June 29, 2022DOI: 10.1056/NEJMc2202092 TO THE EDITOR: The B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a shorter incubation period and a higher transmission rate than previous variants.1,2 Recently, the Centers for Disease Control and Prevention re...

ARTICLES|ONLINE FIRST Outcomes of flucytosine-containing combination treatment for cryptococcal meningitis in a South African national access programme: a cross-sectional observational study Rudzani C Mashau, Susan T Meiring, Vanessa C Quan, et al Lancet Infect Dis Published:June 21, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00234-1 Summary Background Although flucytosine is a key component of WHO-recommended induction treatment for HIV-asso...

Research Letter  June 24, 2022 Olfactory Dysfunction in Patients With Mild COVID-19 During Gamma, Delta, and Omicron Waves in Rio de Janeiro, Brazil Cynthia Chester Cardoso, Átila Duque Rossi, Rafael Mello Galliez, et al JAMA. Published online June 24, 2022. doi:10.1001/jama.2022.11006 Olfactory dysfunction is a common symptom of COVID-19, with reported rates as high as 70%. This symptom can be associated with mild COVID-19, mostly occurs wit...

Original Investigation  Caring for the Critically Ill Patient June 27, 2022 Effect of Nitric Oxide via Cardiopulmonary Bypass on Ventilator-Free Days in Young Children Undergoing Congenital Heart Disease Surgery: The NITRIC Randomized Clinical Trial Luregn J. Schlapbach, Kristen S. Gibbons, Stephen B. Horton, et al JAMA. Published online June 27, 2022. doi:10.1001/jama.2022.9376 Key Points Question  Does nitric oxide applied i...

Editorials Politics and mortality in the United States Steven Woolf BMJ 2022; 377 doi: https://doi.org/10.1136/bmj.o1308 (Published 07 June 2022)Cite this as: BMJ 2022;377:o1308 Mounting evidence suggests a link between republican politics and higher death rates For decades, people in the US have experienced lower life expectancy and poorer health outcomes than populations in other high income countries, and the problem has worsened over time.1 This pe...

Research Industry sponsorship bias in cost effectiveness analysis: registry based analysis Feng Xie, Ting Zhou BMJ 2022; 377 doi: https://doi.org/10.1136/bmj-2021-069573 (Published 22 June 2022)Cite this as: BMJ 2022;377:e069573 Abstract Objective To assess the association between industry sponsorship (drug, medical device, and biotechnology companies) and cost effectiveness results in cost effectiveness analysis (CEA). Design Registry based an...

ICU Management & Practice, Volume 22 - Issue 1, 2022 Diagnostic and Prognostic Value of Estimated Plasma Volume Status An overview of estimated plasma volume (ePVS), recent evidence supporting the association of ePVS with clinical congestion and whether it can help improve outcomes in patients with heart failure (HF). Plasma volume (PV) is the level of intravascular fluid minus the red blood cells, white blood cells and platelets. PV in heart failure (HF...