Original Investigation  June 13, 2022 Mortality Among Patients Undergoing Blood Transfusion in Relation to Donor Sex and Parity: A Natural Experiment Jingcheng Zhao, Arvid Sjölander, Gustaf Edgren JAMA Intern Med. 2022;182(7):747-756. doi:10.1001/jamainternmed.2022.2115 Key Points Question  Does blood donor sex or parity affect mortality of patients undergoing transfusion? Findings  In this nationwide cohort study involving...

Infectious Diseases Society of America Guidance on the Treatment of AmpC β-Lactamase–Producing Enterobacterales, Carbapenem-Resistant Acinetobacter baumannii, and Stenotrophomonas maltophilia Infections Pranita D. Tamma, Samuel L. Aitken, Robert A. Bonomo, et al Clinical Infectious Diseases 2022; 74(12): 2089-2114 AMPC Β-LACTAMASE–PRODUCING ENTEROBACTERALES Question 1: Which Enterobacterales Should Be Considered at Moderate to High Risk for Clinically Signific...

Original Investigation  May 31, 2022 Racial and Ethnic Discrepancy in Pulse Oximetry and Delayed Identification of Treatment Eligibility Among Patients With COVID-19 Ashraf Fawzy,  Tianshi David Wu, Kunbo Wang, et al JAMA Intern Med. 2022;182(7):730-738. doi:10.1001/jamainternmed.2022.1906 Key Points Question  Are there systematic racial and ethnic biases in pulse oximetry among patients with COVID-19, and is there an association betwee...

Clinical, Organisational Factors and COVID-19 Mortality Coronavirus disease 2019 (COVID-19) is one of the most significant challenges faced by critical care workers worldwide. During the COVID-19 pandemic, an unprecedented number of patients with COVID-19 associated pneumonia were admitted to the ICU. As a result, most healthcare facilities faced capacity issues and had to designate clinical areas to accommodate these patients and provide them with the necessary cr...

Original Investigation  May 23, 2022 Assessment of Perioperative Outcomes Among Surgeons Who Operated the Night Before Eric C. Sun, Michelle M. Mello, Michelle T. Vaughn, et al JAMA Intern Med. 2022;182(7):720-728. doi:10.1001/jamainternmed.2022.1563 Key Points Question  Is operating overnight associated with worse outcomes for surgical procedures performed by the attending surgeon the subsequent day? Findings  In this cros...

Original Investigation  August 9, 2022 Effect of Stenting Plus Medical Therapy vs Medical Therapy Alone on Risk of Stroke and Death in Patients With Symptomatic Intracranial Stenosis: The CASSISS Randomized Clinical Trial Peng Gao, Tao Wang, Daming Wang, et al; for the CASSISS Trial Investigators JAMA. 2022;328(6):534-542. doi:10.1001/jama.2022.12000 Key Points Question  Among patients with transient ischemic attack or ischemic s...

Nurse Staffing and Mortality Risk of Sepsis Sepsis is one of the most challenging complications in the ICU. It is a physiologic response to infection that could lead to multiorgan failure and death if not managed and treated properly. Sepsis is a major health issue in the U.S., with more than 1.7 million cases diagnosed annually. Sepsis is also a leading cause of death and one of the most expensive conditions treated by hospitals.  The treatment of sepsis h...

Original Investigation  April 29, 2022 Comparison of Home Antigen Testing With RT-PCR and Viral Culture During the Course of SARS-CoV-2 Infection Victoria T. Chu, Noah G. Schwartz, Marisa A. P. Donnelly, et al, for the COVID-19 Household Transmission Team JAMA Intern Med. 2022;182(7):701-709. doi:10.1001/jamainternmed.2022.1827 Key Points Question  How does the diagnostic performance of home antigen tests change during the course of SA...

Original Investigation  June 27, 2022 Temporal Trends in Antimicrobial Prescribing During Hospitalization for Potential Infection and Sepsis Hallie C. Prescott, Sarah Seelye, Xiao Qing Wang, et al JAMA Intern Med. Published online June 27, 2022. doi:10.1001/jamainternmed.2022.2291 Key Points Question  Is shortening the time to treatment for sepsis associated with increasing antimicrobial use, days of therapy, and broadness of cov...

Articles Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial Urs Fischer, Johannes Kaesmacher, Daniel Strbian, et al Lancet 2022; 400: 104-115 Summary Background Whether thrombectomy alone is equally as effective as intravenous alteplase plus thrombectomy remains controversial. We aimed to determine whether thrombectomy alone would ...