ORIGINAL ARTICLE Phase 1–2 Trial of AAVS3 Gene Therapy in Patients with Hemophilia B Pratima Chowdary, Susan Shapiro, Mike Makris, et al N Engl J Med 2022; 387:237-247DOI: 10.1056/NEJMoa2119913 Abstract BACKGROUND FLT180a (verbrinacogene setparvovec) is a liver-directed adeno-associated virus (AAV) gene therapy that uses a synthetic capsid and a gain-of-function protein to normalize factor IX levels in patients with hemophilia B. METHODS In thi...

ORIGINAL ARTICLE Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022 John P. Thornhill, Sapha Barkati, Sharon Walmsley, et al N Engl J Med July 21, 2022DOI: 10.1056/NEJMoa2207323 Abstract BACKGROUND Before April 2022, monkeypox virus infection in humans was seldom reported outside African regions where it is endemic. Currently, cases are occurring worldwide. Transmission, risk factors, clinical presentation, and outcomes of infectio...

ORIGINAL ARTICLE BNT162b2 Vaccine Effectiveness against Omicron in Children 5 to 11 Years of Age Chandra J. Cohen-Stavi, Ori Magen, Noam Barda, et al N Engl J Med 2022; 387:227-236DOI: 10.1056/NEJMoa2205011 Abstract BACKGROUND Limited evidence is available on the real-world effectiveness of the BNT162b2 vaccine against coronavirus disease 2019 (Covid-19) and specifically against infection with the omicron variant among children 5 to 11 years of age. M...

ICU Management & Practice, Volume 22 - Issue 3, 2022 Delirium: How Can We Protect Our Patients? Detection and Treatment Strategies In this article, the authors aim to summarise the current management of delirium, emphasising new publications and possible new studies that will shed light on delirium management strategy. Introduction According to an updated nomenclature of delirium after an interdisciplinary panel of experts from ten medical societies (...

Research Trajectory of long covid symptoms after covid-19 vaccination: community based cohort study Daniel Ayoubkhani, Charlotte Bermingham, Koen B Pouwels, et al BMJ 2022; 377 doi: https://doi.org/10.1136/bmj-2021-069676 (Published 18 May 2022)Cite this as: BMJ 2022;377:e069676 Abstract Objective To estimate associations between covid-19 vaccination and long covid symptoms in adults with SARS-CoV-2 infection bef...

Original Investigation  July 19, 2022 Effect of Omecamtiv Mecarbil on Exercise Capacity in Chronic Heart Failure With Reduced Ejection Fraction: The METEORIC-HF Randomized Clinical Trial Gregory D. Lewis, Adriaan A. Voors, Alain Cohen-Solal, et al JAMA. 2022;328(3):259-269. doi:10.1001/jama.2022.11016 Key Points Question  Does omecamtiv mecarbil, a novel cardiac myosin activator, improve exercise capacity in patients with heart f...

ICU Management & Practice, Volume 22 - Issue 3, 2022 Practical Implementation of the Pancreatic Stone Protein Sepsis Test An overview of a discussion on sepsis and the Pancreatic Stone Protein (PSP) biomarker by Dr João Pereira, Hospital De Vila Franca De Xira, Portugal and how it can be used for early diagnosis of sepsis and facilitate decision-making regarding the administration of antibiotics. The discussion was chaired by Prof Pedro Póvoa, coordinator o...

CHEST INFECTIONS: ORIGINAL RESEARCH| VOLUME 161, ISSUE 5, P1201-1210, MAY 01, 2022 Primary Prophylaxis for Pneumocystis jirovecii Pneumonia in Patients Receiving Rituximab Jun Won Park, Jeffrey R. Curtis, Kang Il Jun, et al Chest 2022; 161: 1201-1210 Background Although previous studies suggested that rituximab increases the risk of Pneumocystis jirovecii pneumonia (PJP), it is uncertain whether its primary prophylaxis for PJP is ju...

ARTICLES| VOLUME 3, ISSUE 6, E443-E451, JUNE 01, 2022 Gut colonisation by extended-spectrum β-lactamase-producing Escherichia coli and its association with the gut microbiome and metabolome in Dutch adults: a matched case-control study Quinten R Ducarmon, Romy D Zwittink, Roel P J Willems, et al. Lancet Microbe 2022; 3: E443-E451 Published:April 20, 2022 DOI:https://doi.org/10.1016/S2666-5247(22)00037-4 Summary Background Gut colonisati...

ORIGINAL ARTICLE Trial of Erythropoietin for Hypoxic–Ischemic Encephalopathy in Newborns Yvonne W. Wu, Bryan A. Comstock, Fernando F. Gonzalez, et al N Engl J Med 2022; 387:148-159DOI: 10.1056/NEJMoa2119660 Abstract BACKGROUND Neonatal hypoxic–ischemic encephalopathy is an important cause of death as well as long-term disability in survivors. Erythropoietin has been hypothesized to have neuroprotective effects in infants with hypoxic–ischemic encephalopa...