Research Letter  Public Health Mortality Trends Among Early Adults in Germany, 2011 to 2023 Christof Kuhbandner, Matthias Reitzner JAMA Netw Open 2025;8;(10):e2537349. doi:10.1001/jamanetworkopen.2025.37349 Introduction A recent study found that mortality among early adults (aged 25 to 44 years) in the US increased substantially since 2010, following a 2-phase pattern.1 The first phase, through 2019, was characterized by a steady rise in excess...

Original Investigation  Nutrition, Obesity, and Exercise Child Body Mass Index and Health Care Costs in England Olu Onyimadu, Alison Hayes, Patrick Fahr, et al JAMA Netw Open 2025;8;(10):e2537560. doi:10.1001/jamanetworkopen.2025.37560 Key Points Question  What is the health care cost burden attributable to unhealthy weight status among children in England? Findings  In this cross-sectional s...

Artificial Intelligence in Critical Care Medicine In ICU Tue, 22 Jul 2025 Artificial intelligence (AI) has the potential to improve diagnosis, prognostication, workflows, and personalised care in critical care, but implementation without a structured, risk-aware approach may lead to harm. Despite ICU pressures from staffing shortages, case complexity, and rising costs, most AI tools remain poorly validated in real-world settings. A new paper calls f...

Original Investigation  Obstetrics and Gynecology First-Trimester mRNA COVID-19 Vaccination and Risk of Major Congenital Anomalies Clément Bernard, Tom Duchemin, Lise Marty, et al JAMA Netw Open 2025;8;(10):e2538039. doi:10.1001/jamanetworkopen.2025.38039 Key Points Question  Are messenger RNA (mRNA)–based COVID-19 vaccines teratogenic ? Findings  In this nationwide cohort study of 527 564 live-born infants, 130 338 (24.7%) we...

Invited Commentary  Aging and Health The Potential of Music as a Nonpharmacologic Intervention for the ICU—Sound Medicine Farah Acher Kaiksow, Eduard Eric Vasilevskis JAMA Intern Med Published Online: October 13, 2025 doi: 10.1001/jamainternmed.2025.5260 The intensive care unit (ICU) offers lifesaving interventions, but it is also associated with considerable patient pain, anxiety, and high rates of delirium. Delirium in patients in the ICU is a hig...

Original Investigation  AI in Medicine Individualized Prediction of Platelet Transfusion Outcomes in Preterm Infants With Severe Thrombocytopenia Hilde van der Staaij, Ilaria Prosepe, Camila Caram-Deelder, et al JAMA 2025;334;(14):1267-1277. doi:10.1001/jama.2025.14194 Key Points Question  When and in which preterm infants with severe thrombocytopenia do platelet transfusions reduce the risk of major bleeding or death? Findings &nb...

Quality of Life and Functional Recovery After Intensive Care for Sepsis In Sepsis Tue, 15 Jul 2025 Many ICU survivors of sepsis do not fully regain health or normal function, facing issues in cognition, physical, and mental health (post-sepsis syndrome). Recovery, not just survival, is crucial to patients and families, but studies show increased healthcare use post-ICU, indicating incomplete recovery. Health, per WHO, includes physical, mental, an...

Research Letter  Social Media Use Trajectories and Cognitive Performance in Adolescents Jason M. Nagata, Jennifer H. Wong, Kristen E. Kim, et al JAMA Published Online: October 13, 2025 doi: 10.1001/jama.2025.16613 Social media is an increasingly important aspect of early adolescent lives, and trajectories of use have been correlated with negative psychosocial outcomes.1,2 Studies of the link between total screen time and cognitive performance in those ...

Two cases of Middle East respiratory syndrome (MERS) in travellers returning to France from the Arabian Peninsula Epidemiological update 5 Dec 2025 On 3 December 2025, the French Ministry of Health reported two imported human Middle East respiratory syndrome (MERS) cases with travel history to the Arabian Peninsula. The two affected individuals participated in the same group trip. No secondary cases have been identified so far. French authorities are implement...

Editorials Gaza: documenting the trauma of war Derek Summerfield BMJ 2025; 390 doi: https://doi.org/10.1136/bmj.r2012 (Published 25 September 2025)Cite this as: BMJ 2025;390:r2012 Collated descriptions of injuries illustrate the daunting challenges ahead Little is known about patterns of injury in civilians subjected to high intensity bombardments, such as those that occurred during the US and UK invasions of Iraq and Afghanistan and which are now occurring...