ORIGINAL ARTICLE Lower versus Higher Glycemic Criteria for Diagnosis of Gestational Diabetes Caroline A. Crowther, Deborah Samuel, Lesley M.E. McCowan, et al N Engl J Med 2022; 387:587-598DOI: 10.1056/NEJMoa2204091 Abstract BACKGROUND Treatment of gestational diabetes improves maternal and infant health, although diagnostic criteria remain unclear. METHODS We randomly assigned women at 24 to 32 weeks’ gestation in a 1:1 ratio to be evaluated for ge...

ORIGINAL ARTICLE Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19 Carolyn T. Bramante, Jared D. Huling, Christopher J. Tignanelli, et al N Engl J Med 2022; 387:599-610DOI: 10.1056/NEJMoa2201662 Abstract BACKGROUND Early treatment to prevent severe coronavirus disease 2019 (Covid-19) is an important component of the comprehensive response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. METHODS In ...

Original Investigation  August 16, 2022 Association of COVID-19 vs Influenza With Risk of Arterial and Venous Thrombotic Events Among Hospitalized Patients Vincent Lo Re III, Sarah K. Dutcher, John G. Connolly, et al JAMA. 2022;328(7):637-651. doi:10.1001/jama.2022.13072 Key Points Question  Is the 90-day incidence of arterial thromboembolism and venous thromboembolism higher in patients hospitalized with COVID-19 vs in patients ...

ORIGINAL ARTICLEFREE PREVIEW A Randomized Trial of Enteral Glutamine for Treatment of Burn Injuries Daren K. Heyland, Lucy Wibbenmeyer, Jonathan A. Pollack, et al N Engl J Med 2022; 387:1001-1010DOI: 10.1056/NEJMoa2203364 Abstract BACKGROUND Glutamine is thought to have beneficial effects on the metabolic and stress response to severe injury. Clinical trials involving patients with burns and other critically ill patients have shown conflicting results re...

Original Investigation  August 9, 2022 Association of Dual Antiplatelet Therapy With Ticagrelor With Vein Graft Failure After Coronary Artery Bypass Graft Surgery: A Systematic Review and Meta-analysis Sigrid Sandner, Björn Redfors, Dominick J. Angiolillo, et al JAMA. 2022;328(6):554-562. doi:10.1001/jama.2022.11966 Key Points Question  Is ticagrelor dual antiplatelet therapy (DAPT) for patients undergoing coronary artery bypass ...

Original Investigation  August 16, 2022 Effect of Remote Ischemic Conditioning vs Usual Care on Neurologic Function in Patients With Acute Moderate Ischemic Stroke: The RICAMIS Randomized Clinical Trial Hui-Sheng Chen, Yu Cui, Xiao-Qiu Li, et al JAMA. 2022;328(7):627-636. doi:10.1001/jama.2022.13123 Key Points Question  Does remote ischemic conditioning, which involves repeated occlusion/release cycles on bilateral upper limb art...

ORIGINAL ARTICLEFREE PREVIEW Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis Enrique de-Madaria, James L. Buxbaum, Patrick Maisonneuve, et al N Engl J Med 2022; 387:989-1000DOI: 10.1056/NEJMoa2202884 Abstract BACKGROUND Early aggressive hydration is widely recommended for the management of acute pancreatitis, but evidence for this practice is limited. METHODS At 18 centers, we randomly assigned patients who presented with acute pan...

Editorial  August 16, 2022 Remote Ischemic Conditioning: Feasible and Potentially Beneficial for Ischemic Stroke David C. Hess, Rolf A. Blauenfeldt, Grethe Andersen JAMA. 2022;328(7):622-624. doi:10.1001/jama.2022.13365 Stroke is the second leading cause of death and disability in the world.1 In 1996, tissue plasminogen activator (tPA) was approved by the US Food and Drug Administration and remains the only approved pharmacologic agent f...

Editorial  August 9, 2022 Therapeutic Strategies for Intracranial Atherosclerosis Craig S. Anderson, Lili Song, Jianmin Liu JAMA. 2022;328(6):529-531. doi:10.1001/jama.2022.11525 Intracranial atherosclerosis (ICAS) is a major cause of stroke worldwide. Although approximately 12% of White patients with a history of acute ischemic stroke or transient ischemic attack (TIA) have some form of ICAS detected on routine screening in predominantly old...

#EA22: Long-Term Exposure to Air Pollution Increases Risk of Severe COVID-19 New research presented at Euroanaesthesia 2022 finds that long-term exposure to air pollution is linked to a greater risk of severe COVID-19. Findings from the study show that people living in counties with higher levels of nitrogen dioxide (NO2) were more likely to need ICU care and mechanical ventilation if they had COVID-19. Long-term exposure to NO2 can have harmful effects on ...