Awake Prone Positioning for Non-Intubated COVID-19 Patients Prone positioning can improve oxygenation and mortality for intubated patients with moderate to severe acute respiratory distress syndrome (ARDS). Prone positioning of non-intubated patients called awake prone positioning has been used for non-intubated patients with COVID-19 related acute hypoxaemic respiratory failure. It has been proven to improve oxygenation and potentially avoid intubation. Multiple s...

Original Investigation March 14, 2022 Effect of Sotrovimab on Hospitalization or Death Among High-risk Patients With Mild to Moderate COVID-19: A Randomized Clinical Trial Anil Gupta, Yaneicy Gonzalez-Rojas, Erick Juarez, et al JAMA. Published online March 14, 2022. doi:10.1001/jama.2022.2832 Key Points Question  Among patients at risk of disease progression, does early treatment of mild to moderate COVID-19 with the neutralizing an...

Research Letter May 19, 2022 Severity and Incidence of Multisystem Inflammatory Syndrome in Children During 3 SARS-CoV-2 Pandemic Waves in Israel Nitai Levy, Jordanna H. Koppel, Or Kaplan, et al JAMA. Published online May 19, 2022. doi:10.1001/jama.2022.8025 Multisystem inflammatory syndrome in children (MIS-C) is a serious complication of SARS-CoV-2 infection.1 A previous study that described MIS-C cases in the first 3 waves of the COVID-19 pan...

ARTICLES|ONLINE FIRST Myopericarditis following COVID-19 vaccination and non-COVID-19 vaccination: a systematic review and meta-analysis Ryan Ruiyang Ling, Kollengode Ramanathan, Felicia Liying Tan, et al Lancet Respir Med Published:April 11, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00059-5 Summary Background Myopericarditis is a rare complication of vaccination. However, there have been increasing reports of myopericarditis following COVID-19 v...

Findings from the COVID-VENT Trial Many patients with COVID-19-associated acute respiratory failure fulfil the criteria of acute respiratory distress syndrome (ARDS) and require invasive mechanical ventilation. Therefore, it is important to understand the features of gas exchange abnormalities, respiratory mechanics and lung recruitability in these patients to provide an appropriate adjustment of positive end-expiratory pressure (PEEP), the tidal volume (VT) and th...

CORRESPONDENCE|ONLINE FIRST Severe acute hepatitis in children: investigate SARS-CoV-2 superantigens Petter Brodin, Moshe Arditi Lancet Gastroenterol Hepatol Published: May 13, 2022 DOI: https://doi.org/10.1016/S2468-1253(22)00166-2 Recently, there have been reports of children with a severe acute form of hepatitis in the UK, Europe, the USA, Israel, and Japan.1 Most patients present with gastrointestinal symptoms and then progress to jaundice and, in ...

Research Letter February 3, 2022 Prevalence and Durability of SARS-CoV-2 Antibodies Among Unvaccinated US Adults by History of COVID-19 Jennifer L. Alejo, Jonathan Mitchell, Amy Chang, et al JAMA. 2022;327(11):1085-1087. doi:10.1001/jama.2022.1393 As of December 28, 2021, approximately 27% of the US population was unvaccinated against SARS-CoV-2,1 yet the prevalence of natural immunity remains unknown. Blood donor studies may have selection bias and lack ...

ARTICLES|ONLINE FIRST Durability of BNT162b2 vaccine against hospital and emergency department admissions due to the omicron and delta variants in a large health system in the USA: a test-negative case–control study Sara Y Tartof, Jeff M Slezak, Laura Puzniak, et al Lancet Respir Med Published:April 22, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00101-1 Summary Background The duration of protection against the omicron (B.1.1.529) variant for ...

ARTICLES| VOLUME 10, ISSUE 5, P447-458, MAY 01, 2022 Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling analysis Davies Adeloye, Peige Song, Yajie Zhu, et al Lancet Respir Med 2022; 10: 447-458 Summary Background Chronic obstructive pulmonary disease (COPD) is an increasingly important cause of morbidity, disability, and mortality world...

Burnout Syndrome Among Critical Care Clinicians COVID-19 was declared a pandemic by the World Health Organization (WHO) in March 2020. Since then, nearly 100 million patients have been infected worldwide, and millions of deaths have been reported. While healthcare systems overall have been under immense pressure around the world, critical care teams, in particular, have shouldered significant psychological and moral burdens. Increased workload, risk of exposure,...