ICU Management & Practice, Volume 22 - Issue 2, 2022 One Sepsis Fits All? Are There Different Phenotypes of Sepsis? Diagnostic Approaches and Therapies This article presents current research results in relation to an advanced sepsis classification and their implications for new treatment options and research strategies. Introduction Through history, the definition and the term sepsis changed. Since Semmelweis and others formulated the thesis that seps...

Original Investigation  August 10, 2022 Effect of Etomidate vs Propofol for Total Intravenous Anesthesia on Major Postoperative Complications in Older Patients: A Randomized Clinical Trial Zhihong Lu, Hong Zheng, Zhijun Chen, et al JAMA Surg. Published online August 10, 2022. doi:10.1001/jamasurg.2022.3338 Key Points Question  Does etomidate compared with propofol provide a noninferior effect on...

US Preventive Services Task Force  Recommendation Statement August 23/30, 2022 Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: US Preventive Services Task Force Recommendation Statement US Preventive Services Task Force JAMA. 2022;328(8):746-753. doi:10.1001/jama.2022.13044 Abstract Importance  Cardiovascular disease (CVD) is the leading cause of morbidity and death in the US and is the cause of more...

Original Investigation  August 17, 2022 Association of Prehospital Needle Decompression With Mortality Among Injured Patients Requiring Emergency Chest Decompression Daniel Muchnok, Allison Vargo, Andrew-Paul Deeb, et al JAMA Surg. Published online August 17, 2022. doi:10.1001/jamasurg.2022.3552 Key Points Question  Is prehospital needle decompression (PHND) associated with lower 24-hour mortality among trauma patients requiring ...

ICU Management & Practice, Volume 22 - Issue 3, 2022 Ten Overlooked Mistakes During Early Mobilisation in the Intensive Care Unit An overview of the most common mistakes in decision making and the practice of early mobilisation in the intensive care unit. Introduction Early mobilisation (EM) is a therapeutic strategy implemented to avoid and overcome impairments developed due to critical illness and ICU stay. Several benefits have been described throu...

ORIGINAL ARTICLE Nirmatrelvir Use and Severe Covid-19 Outcomes during the Omicron Surge Ronen Arbel, Yael Wolff Sagy, Moshe Hoshen, et al N Engl J Med August 24, 2022DOI: 10.1056/NEJMoa2204919 Abstract BACKGROUND The oral protease inhibitor nirmatrelvir has shown substantial efficacy in high-risk, unvaccinated patients infected with the B.1.617.2 (delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Data regarding the effective...

US Preventive Services Task Force  Evidence Report August 23/30, 2022 Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force Roger Chou, Amy Cantor, Tracy Dana, et al JAMA. 2022;328(8):754-771. doi:10.1001/jama.2022.12138 Abstract Importance  A 2016 review for the US Preventive Services Task Force (USPSTF) found use of s...

ARTICLES|ONLINE FIRST Onset and window of SARS-CoV-2 infectiousness and temporal correlation with symptom onset: a prospective, longitudinal, community cohort study Seran Hakki, Jie Zhou, Jakob Jonnerby, et al Lancet Respir Med Published: August 18, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00226-0 Summary Background Knowledge of the window of SARS-CoV-2 infectiousness is crucial in developing policies to curb transmission. Mathematical modelling...

Original Investigation  August 23/30, 2022 Effect of Aspirin vs Enoxaparin on Symptomatic Venous Thromboembolism in Patients Undergoing Hip or Knee Arthroplasty: The CRISTAL Randomized Trial CRISTAL Study Group JAMA. 2022;328(8):719-727. doi:10.1001/jama.2022.13416 Key Points Question  Is aspirin monotherapy noninferior to enoxaparin in preventing symptomatic venous thromboembolism (VTE) within 90 days following primary total hip...

EDITORIALFREE PREVIEW Fluid Resuscitation in Acute Pancreatitis — Going over the WATERFALL Timothy B. Gardner N Engl J Med 2022; 387:1038-1039DOI: 10.1056/NEJMe2209132 Acute pancreatitis, responsible for approximately 300,000 hospital admissions in the United States annually, is characterized by intense inflammation of the pancreas that leads to severe disease in approximately one third of affected patients.1 Because no proven pharmacologic therapy for acute p...