News News Analysis Covid-19: Stockpiling antivirals risks repeating Tamiflu mistakes, experts warn Gareth Iacobucci BMJ 2022; 377 doi: https://doi.org/10.1136/bmj.o1053 (Published 27 April 2022)Cite this as: BMJ 2022;377:o1053 The UK government has made a huge investment in antivirals to fight covid, but some experts are concerned the waste and overspending of the 2000s will recur. Gareth Iacobucci reports The government’s Antivirals Taskforc...

ORIGINAL ARTICLE Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit François Lamontagne, Marie-Hélène Masse, Julie Menard, et al N Engl J Med June 15, 2022DOI: 10.1056/NEJMoa2200644 Abstract BACKGROUND Studies that have evaluated the use of intravenous vitamin C in adults with sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) have shown mixed results with respect to the risk of death and organ dysfunction....

ARTICLES|ONLINE FIRST Risk of hospitalisation associated with infection with SARS-CoV-2 omicron variant versus delta variant in Denmark: an observational cohort study Peter Bager, Jan Wohlfahrt, Samir Bhatt, et al Lancet Infect Dis Published:April 22, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00154-2 Summary Background Estimates of the severity of the SARS-CoV-2 omicron variant (B.1.1.529) are crucial to assess the public health impact associated...

Research Clinical severity of, and effectiveness of mRNA vaccines against, covid-19 from omicron, delta, and alpha SARS-CoV-2 variants in the United States: prospective observational study Adam S Lauring, Mark W Tenforde, James D Chappell, et al BMJ 2022; 376 doi: https://doi.org/10.1136/bmj-2021-069761 (Published 09 March 2022)Cite this as: BMJ 2022;376:e069761 Abstract Objectives To characterize the clinical severity of covid-19 associated with the a...

Article Monitoring SARS-CoV-2 in air and on surfaces and estimating infection risk in buildings and buses on a university campus Xin Zhang, Jianfeng Wu, Lauren M. Smith, et al J Expo Sci Environ Epidemiol (2022). 27 April 2022 https://doi.org/10.1038/s41370-022-00442-9 Abstract Background Evidence is needed on the presence of SARS-CoV-2 in various types of environmental samples and on the estimated transmission risks in non-healthcare settings on camp...

ICU Management & Practice, Volume 22 - Issue 2, 2022 Gastric Residual Volume – Monitoring and Management An overview of critical care guidelines for enteral nutrition (EN) and the use of gastric residual volume (GRV) management and monitoring as an essential component of EN patient care to help prevent complications. Malnutrition in Critically Ill and the Use of Enteral or Parenteral Nutrition Disease-related malnutrition is a common problem amon...

ARTICLES|ONLINE FIRST Severity of omicron variant of concern and effectiveness of vaccine boosters against symptomatic disease in Scotland (EAVE II): a national cohort study with nested test-negative design Aziz Sheikh, Steven Kerr, Mark Woolhouse, et al Lancet Infect Dis Published:April 22, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00141-4 Summary Background Since its emergence in November, 2021, in southern Africa, the SARS-CoV-2 omicron varian...

Research Letter April 8, 2022 Antibiotic Prescriptions Associated With COVID-19 Outpatient Visits Among Medicare Beneficiaries, April 2020 to April 2021 Sharon V. Tsay, Monina Bartoces, Katryna Gouin, et al JAMA. Published online April 8, 2022. doi:10.1001/jama.2022.5471 Antibiotics are ineffective treatment for viral syndromes, including COVID-19. We characterized antibiotic prescribing in older adults with outpatient COVID-19 visits to identif...

ARTICLES|ONLINE FIRST Awake prone positioning for non-intubated patients with COVID-19-related acute hypoxaemic respiratory failure: a systematic review and meta-analysis Jie Li, Jian Luo, Ivan Pavlov, et al Lancet Respir Med Published: March 16, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00043-1 Summary Background Awake prone positioning has been broadly utilised for non-intubated patients with COVID-19-related acute hypoxaemic respiratory failur...

ARTICLES| VOLUME 22, ISSUE 5, P611-621, MAY 01, 2022 Efficacy and safety of CD24Fc in hospitalised patients with COVID-19: a randomised, double-blind, placebo-controlled, phase 3 study James Welker, Juan D Pulido, Andrew T Catanzaro, et al Lancet Infect Dis 2022; 22: 611-621 Summary Background Non-antiviral therapeutic options are required for the treatment of hospitalised patients with COVID-19. CD24Fc is an immunomodulator with potential...