Original Investigation  September 8, 2022 Five-Year Outcomes in Patients With Fully Magnetically Levitated vs Axial-Flow Left Ventricular Assist Devices in the MOMENTUM 3 Randomized Trial Mandeep R. Mehra, Daniel J. Goldstein, Joseph C. Cleveland, et al JAMA. Published online September 8, 2022. doi:10.1001/jama.2022.16197 Key Points Question  In patients with advanced heart failure, what is the difference in the composite end poi...

Research Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT) David A Jolliffe, Hayley Holt, Matthew Greenig, et al BMJ 2022; 378 doi: https://doi.org/10.1136/bmj-2022-071230 (Published 07 September 2022)Cite this as: BMJ 2022;378:e071230 Abstract Objective To determine the effect of population level implementation of a test-...

ICU Management & Practice, Volume 22 - Issue 2, 2022 Understanding Carbon Dioxide in Resuscitation Peri-arrest CO2 measurement may serve to assess resuscitation efficacy and guide clinical decisions. This paper reviews current knowledge and future research directions for CO2 measurement and clinical application during CPR. Carbon Dioxide During Normal Heart-Lung Function CO2 is produced by the mitochondria as a major end product of tiss...

Original Investigation  August 26, 2022 Concordance of SARS-CoV-2 Results in Self-collected Nasal Swabs vs Swabs Collected by Health Care Workers in Children and Adolescents Jesse J. Waggoner, Miriam B. Vos, Erika A. Tyburski, et al JAMA. Published online August 26, 2022. doi:10.1001/jama.2022.14877 Key Points Question  Are children and adolescents, aged 4 to 14 years, able to adequately self-collect nasal swabs for SARS-CoV-2 te...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalExtubation in neurocritical care patients: the ENIO international prospective studyCinotti R. et al. Management and outcomes of pregnant women admitted to intensive care unit for severe pneumonia related to SARS-CoV-2 infection: the multicenter and international COVIDPREG studyPéju E. et al. Mental health-related quality of life is related to delirium in intensive care patientsHofhuis J.G.M., Schermer T. and S...

JAMA Clinical Guidelines Synopsis  August 8, 2022 Treatment of Clostridioides difficile Infection Kanika Sehgal, Adam S. Cifu, Sahil Khanna JAMA. Published online August 8, 2022. doi:10.1001/jama.2022.12251 Guideline title ACG Clinical Guidelines: Prevention, Diagnosis, and Treatment of Clostridioides difficile Infections Release date May 18, 2021 Prior version 2013 Developer American College o...

ICU Management & Practice, Volume 22 - Issue 2, 2022 The Alphabet Book of Sepsis In this article, the author provides the alphabet review of sepsis and septic shock based on personal clinical experience and choice. Sepsis and septic shock have been defined in 2016 (Singer et al. 2016) and the management of patients is framed by the Surviving Sepsis Campaign guidelines with its renewed version in 2021 (Evans et al. 2021). Using PubMed, around 15,000 hits ...

ORIGINAL ARTICLE Efficacy and Safety of an Extravascular Implantable Cardioverter–Defibrillator Paul Friedman, Francis Murgatroyd, Lucas V.A. Boersma, et al N Engl J Med August 28, 2022DOI: 10.1056/NEJMoa2206485 Abstract BACKGROUND The extravascular implantable cardioverter–defibrillator (ICD) has a single lead implanted substernally to enable pause-prevention pacing, antitachycardia pacing, and defibrillation energy similar to that of transvenous ICDs. ...

ORIGINAL ARTICLE Fractional Flow Reserve or Intravascular Ultrasonography to Guide PCI Bon-Kwon Koo, Xinyang Hu, Jeehoon Kang, et al N Engl J Med 2022; 387:779-789DOI: 10.1056/NEJMoa2201546 Abstract BACKGROUND In patients with coronary artery disease who are being evaluated for percutaneous coronary intervention (PCI), procedures can be guided by fractional flow reserve (FFR) or intravascular ultrasonography (IVUS) for decision making regarding revascula...

ICU Management & Practice, Volume 22 - Issue 2, 2022 Symmetrical Peripheral Gangrene In this article, the authors describe the presentation, pathophysiology, and potential treatment options for symmetrical peripheral gangrene. Limitations in the current literature and a possible strategy for future study are highlighted. Introduction Symmetrical peripheral gangrene (SPG) refers to the development of tissue necrosis in an acral distribution without vas...