ORIGINAL ARTICLE Restriction of Intravenous Fluid in ICU Patients with Septic Shock T.S. Meyhoff, P.B. Hjortrup, J. Wetterslev, et al N Engl J Med June 17, 2022DOI: 10.1056/NEJMoa2202707 BACKGROUND Intravenous fluids are recommended for the treatment of patients who are in septic shock, but higher fluid volumes have been associated with harm in patients who are in the intensive care unit (ICU). METHODS In this international, randomized trial, we ...

Original Investigation May 5, 2022 Association Between Use of a Flying Intervention Team vs Patient Interhospital Transfer and Time to Endovascular Thrombectomy Among Patients With Acute Ischemic Stroke in Nonurban Germany Gordian J. Hubert, Nikolai D. Hubert, Christian Maegerlein, et al JAMA. 2022;327(18):1795-1805. doi:10.1001/jama.2022.5948 Key Points Question  In a nonurban region in Germany, is the deployment of a flying intervention tea...

Original Investigation Caring for the Critically Ill PatientMarch 22, 2022 Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial REMAP-CAP Writing Committee for the REMAP-CAP Investigators JAMA. Published online March 22, 2022. doi:10.1001/jama.2022.2910 Key Points Question  Does antiplatelet therapy administered to critically ill patients with CO...

ARTICLES| VOLUME 4, ISSUE 3, E177-E187, MARCH 01, 2022 Humoral and cellular immune responses to two and three doses of SARS-CoV-2 vaccines in rituximab-treated patients with rheumatoid arthritis: a prospective, cohort study Ingrid Jyssum, Hassen Kared, Trung T Tran, et al Lancet Rheumatol 2022; 4: e177-e187 Summary Background In rituximab-treated patients with rheumatoid arthritis, humoral and cellular immune responses after two or three d...

Original Investigation  June 16, 2022 Effect of Fluid Bolus Administration on Cardiovascular Collapse Among Critically Ill Patients Undergoing Tracheal Intubation: A Randomized Clinical Trial Derek W. Russell, Jonathan D. Casey, Kevin W. Gibbs, et al JAMA. Published online June 16, 2022. doi:10.1001/jama.2022.9792 Key Points Question  In critically ill adult patients undergoing tracheal intubation, does intravenous infusion of a ...

Original Investigation May 5, 2022 Effect of Direct Transportation to Thrombectomy-Capable Center vs Local Stroke Center on Neurological Outcomes in Patients With Suspected Large-Vessel Occlusion Stroke in Nonurban Areas: The RACECAT Randomized Clinical Trial Natalia Pérez de la Ossa, Sònia Abilleira, Tudor G. Jovin, et al JAMA. 2022;327(18):1782-1794. doi:10.1001/jama.2022.4404 Key Points Question  In patients experiencing suspected large-ve...

Original Investigation March 22/29, 2022 Association of Neonatal Hypoglycemia With Academic Performance in Mid-Childhood Rajesh Shah, Darren W. T. Dai, Jane M. Alsweiler, et al JAMA. 2022;327(12):1158-1170. doi:10.1001/jama.2022.0992 Key Points Question  Among children born at risk of neonatal hypoglycemia, do those who experience hypoglycemia have worse academic performance in mid-childhood? Findings  In this prospecti...

ARTICLES|ONLINE FIRST Efficacy of 12-months oral itraconazole versus 6-months oral itraconazole to prevent relapses of chronic pulmonary aspergillosis: an open-label, randomised controlled trial in India Inderpaul S Sehgal, Sahajal Dhooria, Valliappan Muthu, et al Lancet Infect Dis Published:April 13, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00057-3 Summary Background Chronic pulmonary aspergillosis has a 5-year mortality of 50–80% globally, and...

Original Investigation  Caring for the Critically Ill Patient June 16, 2022 Effect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Therapy on Liberation From Respiratory Support in Acutely Ill Children Admitted to Pediatric Critical Care Units: A Randomized Clinical Trial Padmanabhan Ramnarayan, Alvin Richards-Belle, Laura Drikite, et al JAMA. Published online June 16, 2022. doi:10.1001/jama.2022.9615 Key Poi...

Research Letter February 11, 2022 Association of Homologous and Heterologous Vaccine Boosters With COVID-19 Incidence and Severity in Singapore Sharon Hui Xuan Tan, Rachael Pung, Lin-Fa Wang, et al JAMA. 2022;327(12):1181-1182. doi:10.1001/jama.2022.1922 Reports of waning antibody levels and breakthrough infections among vaccinated individuals1have prompted the recommendation for vaccine boosters to prevent SARS-CoV-2 infections. Despite more than 80% of ...