Original Investigation  June 1, 2022 Using Artificial Intelligence to Find the Optimal Margin Width in Hepatectomy for Colorectal Cancer Liver Metastases Dimitris Bertsimas, Georgios Antonios Margonis, Suleeporn Sujichantararat, et al JAMA Surg. 2022;157(8):e221819. doi:10.1001/jamasurg.2022.1819 Key Points Question  What is the optimal margin width for hepatectomy for colorectal cancer liver metastases and should it be individualized base...

VA-LRTI Infections in COVID-19 COVID-19 continues to create a strain on healthcare systems around the world. Approximately 10-30% of COVID-19 patients admitted to the hospital need ICUs, and 15-20% of these patients require ventilatory support. The available data shows an increased risk of ventilator-associated pneumonia (VAP) and ventilator-associated lower respiratory tract infections (VA-LRTI) in critically ill COVID-19 patients. VA-LRTIs can result in a prolong...

Original Investigation  September 7, 2022 Bihormonal Artificial Pancreas With Closed-Loop Glucose Control vs Current Diabetes Care After Total Pancreatectomy: A Randomized Clinical Trial Charlotte L. van Veldhuisen, Anouk E. J. Latenstein, Helga Blauw, et al JAMA Surg. Published online September 7, 2022. doi:10.1001/jamasurg.2022.3702 Key Points Question  What is the efficacy and safety of the novel bihormonal artificial pancreas...

Original Investigation  June 8, 2022 Association Between Implementation of a Geriatric Trauma Clinical Pathway and Changes in Rates of Delirium in Older Adults With Traumatic Injury Caroline Park, Ankur Bharija, Matthew Mesias, et al JAMA Surg. 2022;157(8):676-683. doi:10.1001/jamasurg.2022.1556 Key Points Question  Is the establishment of a geriatric-centered clinical pathway associated with improved outcomes in older adults with traumati...

Original Investigation  July 11, 2022 Association of Sociodemographic Characteristics With US Medical Student Attrition Mytien Nguyen,Sarwat I. Chaudhry, Mayur M. Desai, et al JAMA Intern Med. 2022;182(9):917-924. doi:10.1001/jamainternmed.2022.2194 Key Points Question  How do the medical student attrition rates compare across racial, ethnic, and socioeconomic identities? Findings  In this cohort study of 33 389 allopathic doc...

ICU Management & Practice, Volume 22 - Issue 2, 2022 ICU Management of the Very Old: The Evidence Base Anno 2022 This overview explores the publications concerning the very old ICU patients since 2011 and with a focus on publications from the VIP network on elderly COVID-19 patients. Introduction In 2017, an international group of intensivists with a particular interest for geriatric intensive care published a statement paper (Flaatten et al. 2017). T...

Original Investigation  July 18, 2022 Clinical Outcomes and Cost Associated With an Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump in Patients Presenting With Acute Myocardial Infarction Complicated by Cardiogenic Shock P. Elliott Miller, MD, Samantha G. Bromfield, Qinli Ma, et al JAMA Intern Med. 2022;182(9):926-933. doi:10.1001/jamainternmed.2022.2735 Key Points Question  Is there a difference in sho...

Editorials Can vitamin D protect against covid-19? Peter Bergman BMJ 2022; 378 doi: https://doi.org/10.1136/bmj.o1822 (Published 07 September 2022)Cite this as: BMJ 2022;378:o1822 Two new trials find no effect, but aren’t the final word Vitamin D is an important regulator of calcium balance. In addition, it has important effects on the immune system, directly inducing antimicrobial peptides at mucosal surfaces and modulating the function of T cells.12Observ...

#ISICEM22: The Place of Antiplatelet Agents in COVID-19 (REMAP-CAP Trial) Thrombotic events are common in patients hospitalised with COVID-19. Platelet activation has been implicated in the COVID-19 inflammatory response. However, the efficacy of antiplatelet therapy in critically ill patients with COVID-19 is still uncertain.  The Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP) trial aimed to answer...

Research Prevention of covid-19 and other acute respiratory infections with cod liver oil supplementation, a low dose vitamin D supplement: quadruple blinded, randomised placebo controlled trial Sonja H Brunvoll, Anders B Nygaard, Merete Ellingjord-Dale, et al BMJ 2022; 378 doi: https://doi.org/10.1136/bmj-2022-071245 (Published 07 September 2022)Cite this as: BMJ 2022;378:e071245 Abstract Objective To deter...