Original Investigation  October 4, 2022 Effect of a Postoperative Multimodal Opioid-Sparing Protocol vs Standard Opioid Prescribing on Postoperative Opioid Consumption After Knee or Shoulder Arthroscopy: A Randomized Clinical Trial The NO PAin Investigators JAMA. 2022;328(13):1326-1335. doi:10.1001/jama.2022.16844 Key Points Question  Does a multimodal opioid-sparing postoperative pain protocol reduce postoperative opioid consump...

Original Investigation  October 4, 2022 Effect of Cefepime/Enmetazobactam vs Piperacillin/Tazobactam on Clinical Cure and Microbiological Eradication in Patients With Complicated Urinary Tract Infection or Acute Pyelonephritis: A Randomized Clinical Trial Keith S. Kaye, Adam Belley, Philip Barth, et al JAMA. 2022;328(13):1304-1314. doi:10.1001/jama.2022.17034 Key Points Question  How does the efficacy of cefepime/enmetazobactam c...

ORIGINAL RESEARCH|ARTICLES IN PRESS Recall of awareness during paralysis among emergency department patients undergoing tracheal intubation Brian E. Driver, Matthew E. Prekker, Emily Wagner, et al Chest Published:September 08, 2022 DOI:https://doi.org/10.1016/j.chest.2022.08.2232 ABSTRACT Background Critically ill patients sometimes remember periods of neuromuscular blockade. Research Question What is the prevalence of recalled awareness during ...

Enteral Nutrition Practices in ICU Patients With Circulatory Shock Approximately one-third of patients admitted to the ICU are in circulatory shock, which increases the risk of mortality. Death from circulatory shock is preceded by multiple organ dysfunction syndrome with a high mortality rate of over 80%. Loss of gut epithelial barrier function contributes to gut-derived proinflammatory immune responses that contribute to multiple organ dysfunction.  Studi...

ARTICLES|ONLINE FIRST Artificial intelligence-guided screening for atrial fibrillation using electrocardiogram during sinus rhythm: a prospective non-randomised interventional trial Peter A Noseworthy, Zachi I Attia, Emma M Behnken, et al  Lancet Published:September 27, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)01637-3 Summary Background Previous atrial fibrillation screening trials have highlighted the need for more targeted approaches. We did a...

ORIGINAL ARTICLE A Bivalent Omicron-Containing Booster Vaccine against Covid-19 Spyros Chalkias, Charles Harper, Keith Vrbicky, et al N Engl J Med September 16, 2022DOI: 10.1056/NEJMoa2208343 Abstract BACKGROUND The safety and immunogenicity of the bivalent omicron-containing mRNA-1273.214 booster vaccine are not known. METHODS In this ongoing, phase 2–3 study, we compared the 50-μg bivalent vaccine mRNA-1273.214 (25 μg each of ancestral Wuhan-Hu-1...

Therapeutic Hyperthermia and Survival in Afebrile Sepsis Patients Fever is an important feature of infection. However, fewer than half of patients with sepsis present with fever at the time of diagnosis. Afebrile sepsis patients have nearly twice the mortality and are at a higher risk of developing secondary infections than patients with fever.  Fever is an adaptive response to infection that may be critical for survival. Studies show that elevated temperat...

Original Investigation  September 27, 2022 Effect of High-Flow Nasal Cannula Oxygen vs Standard Oxygen Therapy on Mortality in Patients With Respiratory Failure Due to COVID-19: The SOHO-COVID Randomized Clinical Trial Jean-Pierre Frat, Jean-Pierre Quenot, Julio Badie, et al JAMA. 2022;328(12):1212-1222. doi:10.1001/jama.2022.15613 Key Points Questions  In patients with respiratory failure due to COVID-19, does the use of high-fl...

CORRESPONDENCE IL-1RA Antibodies in Myocarditis after SARS-CoV-2 Vaccination Lorenz Thurner, Christoph Kessel, Natalie Fadle, et al N Engl J Med September 21, 2022DOI: 10.1056/NEJMc2205667 TO THE EDITOR: Myocarditis associated with messenger RNA (mRNA) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) predominantly affects male adolescents and young male adults (14 to <30 years of age) and typically occurs after receipt of the...

JAMA Clinical Guidelines Synopsis  September 15, 2022 Management of Heart Failure Mark N. Belkin, Adam S. Cifu, Sean Pinney JAMA. Published online September 15, 2022. doi:10.1001/jama.2022.16667 Guideline title 2022 American College of Cardiology (ACC)/American Heart Association AHA)/Heart Failure Society of America (HFSA) Guidelines for the Management of Heart Failure Release date April 1, 2022 Prior versions 2017 ACC/AH...