ARTICLES|ONLINE FIRST Measuring the availability of human resources for health and its relationship to universal health coverage for 204 countries and territories from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019 GBD 2019 Human Resources for Health Collaborators Lancet 2022 Published: May 23, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)00532-3 Summary Background Human resources for health (HRH) include a range of ...

ICU Capacity Transfers and Mortality Transfers from one ICU to another ICU are associated with an increased length of stay in the ICU and the hospital. Inter-hospital ICU transfers occur for three main reasons: clinical transfers, capacity transfers and repatriations.  A study was conducted to show that different ICU transfers differ in risk-adjusted mortality rate. The primary endpoint of the study was survival to 30 days. The secondary endpoint included s...

Original Investigation May 13, 2022 Association of Prior BNT162b2 COVID-19 Vaccination With Symptomatic SARS-CoV-2 Infection in Children and Adolescents During Omicron Predominance Katherine E. Fleming-Dutra, Amadea Britton, Nong Shang, et al JAMA. Published online May 13, 2022. doi:10.1001/jama.2022.7493 Key Points Question  Does the estimated effectiveness of 2 doses of the BNT162b2 COVID-19 vaccine against symptomatic SARS-CoV-2 ...

ARTICLES|ONLINE FIRST Safety, immunogenicity, and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCoV-19 or BNT162b2 and a third dose of BNT162b2 (COV-BOOST): a multicentre, blinded, phase 2, randomised trial Alasdair P S Munro, Shuo Feng, Leila Janani, et al Lancet Infect Dis Published:May 09, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00271-7 Summary Background Some high-in...

ICU-Related Loss of Quality of Life After COVID-19 COVID-19 has had a significant impact on the number of hospital admissions, including many patients presenting acute respiratory failure. Approximately 15% of hospitalised COVID-19 patients require ICU admission.  It is well established that the physical and psychological impact of an ICU stay on patients can be quite significant and prolonged. Many ICU survivors report functional disability that can persis...

ARTICLES| VOLUME 399, ISSUE 10340, P2047-2064, MAY 28, 2022 Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis You Li, Xin Wang, Dianna M Blau, et al Lancet 2022; 399: 2047-2064 Summary Background Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory infection in young...

ARTICLES|ONLINE FIRST Venous or arterial thrombosis and deaths among COVID-19 cases: a European network cohort study Edward Burn, Talita Duarte-Salles, Sergio Fernandez-Bertolin, et al Lancet Infect Dis Published:May 13, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00223-7 Summary Background There are few data on the incidence of thrombosis among COVID-19 cases, with most research concentrated on hospitalised patients. We aimed to estimate the incid...

Original Investigation May 15, 2022 Effect of Robot-Assisted Radical Cystectomy With Intracorporeal Urinary Diversion vs Open Radical Cystectomy on 90-Day Morbidity and Mortality Among Patients With Bladder Cancer: A Randomized Clinical Trial James W. F. Catto, Pramit Khetrapal, Federico Ricciardi, et al JAMA. Published online May 15, 2022. doi:10.1001/jama.2022.7393 Key Points Question  Does robot-assisted surgery improve periopera...

CORRESPONDENCE Omicron BA.1/1.1 SARS-CoV-2 Infection among Vaccinated Canadian Adults Patrick E. Brown, Sze Hang Fu, Aiyush Bansal, et al N Engl J Med May 18, 2022DOI: 10.1056/NEJMc2202879 TO THE EDITOR: The incidence of the omicron BA.1/1.1 variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which rapidly spread worldwide even among vaccinated persons, is incompletely defined.1 We quantified the incidence of SARS-CoV-2 infection d...

#ISICEM22: Vasodilatory Choice and Timing An article released in conjunction with the Intensive Care & Emergency Medicine (ISICEM) Congress helps clinicians understand the choice and timing of vasopressors in vasodilatory shock. It is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2022. Vasodilatory shock is one of the most common forms encountered in patients admitted to the ICU. The predominant aetiology of th...