Research Waning of vaccine effectiveness against moderate and severe covid-19 among adults in the US from the VISION network: test negative, case-control study Jill M Ferdinands, Suchitra Rao, Brian E Dixon, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072141 (Published 03 October 2022)Cite this as: BMJ 2022;379:e072141 Abstract Objective To estimate the effectiveness of mRNA vaccines against moderate and severe covid-19 in adults by time ...

ORIGINAL ARTICLE Spontaneous-Breathing Trials with Pressure-Support Ventilation or a T-Piece Arnaud W. Thille, Arnaud Gacouin, Rémi Coudroy, et al N Engl J Med October 26, 2022DOI: 10.1056/NEJMoa2209041 BACKGROUND Spontaneous-breathing trials can be performed with the use of either pressure-support ventilation (PSV) or a T-piece. Whether PSV trials may result in a shorter time to tracheal extubation than T-piece trials, without resulting in a higher risk of...

Research External validation of a prediction model for estimating fat mass in children and adolescents in 19 countries: individual participant data meta-analysis Mohammed T Hudda, Jonathan C K Wells,  Linda S Adair, et al BMJ 2022; 378 doi: https://doi.org/10.1136/bmj-2022-071185 (Published 21 September 2022)Cite this as: BMJ 2022;378:e071185 Abstract Objective To evaluate the performance of a UK based prediction model for estimating fat-free mass (and...

Renal Replacement Therapy in Patients With Sepsis-Associated AKI Acute kidney injury (AKI) is a serious complication of sepsis. According to data from several clinical studies, AKI can occur in nearly 50% of patients with sepsis and has a mortality rate of approximately 60% at three months.  Renal replacement therapy (RRT) is used to treat AKI, but some data show that it exerts only a limited effect in patients with sepsis-associated AKI (SA-AKI). ...

Research Effectiveness of a behavioural intervention delivered by text messages (safetxt) on sexually transmitted reinfections in people aged 16-24 years: randomised controlled trial Caroline Free, Melissa J Palmer, Ona L McCarthy, et al BMJ 2022; 378 doi: https://doi.org/10.1136/bmj-2022-070351 (Published 28 September 2022)Cite this as: BMJ 2022;378:e070351 Abstract Objective To quantify the effects of a series of text messages (safetxt) delivered in ...

Research Comparison of short term surgical outcomes of male and female gastrointestinal surgeons in Japan: retrospective cohort study Kae Okoshi, Hideki Endo, Sachiyo Nomura, et al BMJ 2022; 378 doi: https://doi.org/10.1136/bmj-2022-070568 (Published 28 September 2022)Cite this as: BMJ 2022;378:e070568 Abstract Objective To compare short term surgical outcomes between male and female gastrointestinal surgeons in Japan. Design Retrospective coho...

Intravenous Vitamin C in ICU Patients with Sepsis Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis contributes to between a third and a half of deaths in hospitals. It is responsible for nearly 11 million deaths worldwide each year. Treatment of sepsis typically includes antimicrobial therapy, source control, and organ support. It is believed that the antioxidant effects of vitamin C therapy may mitigate tis...

JAMA Clinical Guidelines Synopsis  September 15, 2022 Management of Heart Failure Mark N. Belkin, Adam S. Cifu, Sean Pinney JAMA. 2022;328(13):1346-1347. doi:10.1001/jama.2022.16667 Guideline title 2022 American College of Cardiology (ACC)/American Heart Association AHA)/Heart Failure Society of America (HFSA) Guidelines for the Management of Heart Failure Release date April 1, 2022 Prior versions 2017 ACC/AHA/HFSA Focused Update o...

Research Letter  August 22, 2022 Compassionate Use of Tecovirimat for the Treatment of Monkeypox Infection Angel N. Desai, George R. Thompson III, Sonja M. Neumeister, et al JAMA. 2022;328(13):1348-1350. doi:10.1001/jama.2022.15336 Monkeypox is a zoonotic orthopoxvirus in the same genus as variola (the causative agent of smallpox).1 A recent global outbreak has led to more than 39 000 cases reported as of August 18, 2022.2 Monkeypox is typica...

Mental Health Morbidity Among ICU Survivors and Caregivers There is significant evidence that patients who survive critical illness experience morbidity after discharge from the ICU. This is commonly referred to as the post-intensive care syndrome (PICS). In addition to a negative impact on the physical health of ICU survivors, PICS also includes mental health morbidity.  Studies have shown that mechanically ventilated ICU survivors have a higher incidence ...