Long COVID and Recovery Following Hospitalisation More than 500 million cases of COVID-19 have been reported worldwide. Patients infected with COVID-19 are at a higher risk of persisting health impairments six months after hospital discharge associated with reduced physical function and health and quality of life. It is thus important to understand the long-term trajectory of recovery from COVID-19. There is very limited information about the long-term sequelae ...

Original Investigation  June 5, 2022 Effect of Electronic Symptom Monitoring on Patient-Reported Outcomes Among Patients With Metastatic Cancer: A Randomized Clinical Trial Ethan Basch, Deborah Schrag, Sydney Henson, et al JAMA. Published online June 5, 2022. doi:10.1001/jama.2022.9265 Key Points Question  In patients undergoing cancer treatment, does electronic symptom monitoring improve quality-of-life (QOL) outcomes? Findin...

Medical News & Perspectives  June 8, 2022 American Thoracic Society 2022 Conference Highlights Kristin Walter JAMA. Published online June 8, 2022. doi:10.1001/jama.2022.8598 Studies that examined whether prone positioning or undergoing a lung transplant are effective approaches in treating COVID-19 were among the diverse presentations at the American Thoracic Society’s (ATS) recent annual conference. In this May 26 conversation, Andrew J....

Research Letter  June 13, 2022 Updated US Infection- and Vaccine-Induced SARS-CoV-2 Seroprevalence Estimates Based on Blood Donations, July 2020-December 2021 Jefferson M. Jones, Jean D. Opsomer, Mars Stone, et al JAMA. Published online June 13, 2022. doi:10.1001/jama.2022.9745 By testing for both SARS-CoV-2 spike and nucleocapsid antibodies, seroprevalence studies can estimate the proportion of a population with antibodies from previous infe...

Less is More in Delirium Critical care physicians often use ineffective treatments that lack evidence-based data. This is especially true for delirium. To date, no medications have demonstrated therapeutic benefit for this condition. Medical treatment is either targeted toward preventing delirium or treating agitation associated with it. Behavioural interventions are rarely incorporated.  Delirium has a high incidence among critically ill patients. Approxim...

Viewpoint  June 7, 2022 Reducing SARS-CoV-2 in Shared Indoor Air Deborah Dowell, William G. Lindsley, John T. Brooks JAMA. Published online June 7, 2022. doi:10.1001/jama.2022.9970 SARS-CoV-2 replicates in the respiratory tract and spreads through exhalation of infectious respiratory particles. The chances of transmission increase the longer an uninfected person stays in an enclosed space with an infected person. Infection can occur not only ...

Research Effectiveness of heterologous and homologous covid-19 vaccine regimens: living systematic review with network meta-analysis Wing Ying Au, Peter Pak-Hang Cheung BMJ 2022; 377 doi: https://doi.org/10.1136/bmj-2022-069989 (Published 31 May 2022)Cite this as: BMJ 2022;377:e069989 Abstract Objective To evaluate the effectiveness of heterologous and homologous covid-19 vaccine regimens with and without boosting in preventing covid-19 related infecti...

ARTICLES| VOLUME 399, ISSUE 10342, P2191-2199, JUNE 11, 2022 Risk of myocarditis and pericarditis after the COVID-19 mRNA vaccination in the USA: a cohort study in claims databases Hui-Lee Wong, Mao Hu, Cindy Ke Zhou, et al Lancet 2022; 399: 2191-2199 Summary Background Several passive surveillance systems reported increased risks of myocarditis or pericarditis, or both, after COVID-19 mRNA vaccination, especially in young men. We used act...

ICU Management & Practice, Volume 22 - Issue 1, 2022 Information Transfer as a Strategy to Improve Safety in ICU The transmission of information (TOI) in extremely variable environments, such as the ICU, is crucial. The content and how it is transmitted can be decisive in the safe care of the critical patient. Introduction In an Intensive Care Unit (ICU), we attend people with a wide range of pathologies. All the information obtained from monitoring o...

ARTICLES| VOLUME 399, ISSUE 10342, P2212-2225, JUNE 11, 2022 Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine in children aged 6–17 years: a preliminary report of COV006, a phase 2 single-blind, randomised, controlled trial Grace Li, Federica Cappuccini, Natalie G Marchevsky, et al Lancet 2022; 399: 2212-2225 Summary Background Vaccination of children and young people against SARS-CoV-2 is recommended in some countries. S...