CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 162, ISSUE 4, P796-803, OCTOBER 01, 2022 Comparison of Heart Rate After Phenylephrine vs Norepinephrine Initiation in Patients With Septic Shock and Atrial Fibrillation Anica C. Law, Nicholas A. Bosch, Daniel Peterson, et al Chest 2022; 162: 796-803 Background Atrial fibrillation (AF) is a common complication of sepsis. It is unclear whether norepinephrine, an α- and β-agonist, and phenylephrine, an α-...

ARTICLES| VOLUME 4, ISSUE 10, E668-E678, OCTOBER 01, 2022 Sex differences in clinical outcomes and biological profiles in systemic sclerosis-associated interstitial lung disease: a post-hoc analysis of two randomised controlled trials Elizabeth R Volkmann, Donald P Tashkin, Richard Silver, et al Lancet Rheumatol 2022; 4: E668-E678 Summary Background Observational studies have shown that men with systemic sclerosis have an increased risk of...

Preliminary Communication  October 11, 2022 Effect of Paroxetine or Quetiapine Combined With Oxycodone vs Oxycodone Alone on Ventilation During Hypercapnia: A Randomized Clinical Trial Jeffry Florian, Rutger van der Schrier, Victoria Gershuny, et al JAMA. 2022;328(14):1405-1414. doi:10.1001/jama.2022.17735 Key Points Question  Do specific psychotropic drug–opioid combinations further decrease the ventilatory response to hypercapn...

Ventilatory Settings and Outcomes in OHCA patients Protective ventilation strategies are commonly applied in patients after cardiac arrest. However, the optimal ventilatory settings in these patients and their association with patient outcomes remain unclear.  The goal of this study was to describe the ventilatory settings applied in the first 72 hours of mechanical ventilation in patients after out-of-hospital cardiac arrest (OHCA) and their association wi...

ARTICLES| VOLUME 3, ISSUE 10, E762-E771, OCTOBER 01, 2022 Efficacy of different preoperative skin antiseptics on the incidence of surgical site infections: a systematic review, GRADE assessment, and network meta-analysis Hasti Jalalzadeh, Hannah Groenen, Dennis R Buis, et al Lancet Microbe 2022; 3: E762-E771 Summary Background Surgical site infection (SSI) is the most common postoperative complication and substantially increases health-car...

ARTICLES|ONLINE FIRST Intermediate-dose versus low-dose low-molecular-weight heparin in pregnant and post-partum women with a history of venous thromboembolism (Highlow study): an open-label, multicentre, randomised, controlled trial Ingrid M Bistervels, Andrea Buchmüller, Hanke M G Wiegers, et al Lancet Published:October 28, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)02128-6 Summary Background Pregnancy-related venous thromboembolism is a leading...

ARTICLES|ONLINE FIRST Intensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial Pengfei Yang, Lili Song, Yongwei Zhang, et al Lancet Published:October 27, 2022 DOI: https://doi.org/10.1016/S0140-6736(22)01882-7 Summary Background The optimum systolic blood pressure after endovascular thrombectomy for acute ischaemic stroke is unc...

Long vs Short Duration Antibiotic Therapy for VAP Ventilator-associated pneumonia (VAP) is a major cause of morbidity and mortality in the ICU. It accounts for nearly 25% of infections in ICU patients. While there are guidelines to treat VAP, uncertainties remain when treating VAP due to Pseudomonas aeruginosa (PA-VAP), and the optimal duration of antibiotic therapy continues to be debated. In addition, there is limited evidence regarding the recurrence r...

ARTICLES| VOLUME 400, ISSUE 10359, P1213-1222, OCTOBER 08, 2022 Real-world effectiveness of molnupiravir and nirmatrelvir plus ritonavir against mortality, hospitalisation, and in-hospital outcomes among community-dwelling, ambulatory patients with confirmed SARS-CoV-2 infection during the omicron wave in Hong Kong: an observational study Carlos K H Wong, Ivan C H Au, Kristy T K Lau, et al Lancet 2022; 400: 1213-1222 Published:October 08, 2022 D...

Research Association between initiation of fluoroquinolones and hospital admission or emergency department visit for suicidality: population based cohort study Junyi Wang, Joshua J Gagne, Sushama Kattinakere-Sreedhara, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2021-069931 (Published 04 October 2022)Cite this as: BMJ 2022;379:e069931 Abstract Objective To evaluate the association between initiation of fluoroquinolones and hospital admission o...