Research Letter  June 24, 2022 Olfactory Dysfunction in Patients With Mild COVID-19 During Gamma, Delta, and Omicron Waves in Rio de Janeiro, Brazil Cynthia Chester Cardoso, Átila Duque Rossi, Rafael Mello Galliez, et al JAMA. Published online June 24, 2022. doi:10.1001/jama.2022.11006 Olfactory dysfunction is a common symptom of COVID-19, with reported rates as high as 70%. This symptom can be associated with mild COVID-19, mostly occurs wit...

Original Investigation  Caring for the Critically Ill Patient June 27, 2022 Effect of Nitric Oxide via Cardiopulmonary Bypass on Ventilator-Free Days in Young Children Undergoing Congenital Heart Disease Surgery: The NITRIC Randomized Clinical Trial Luregn J. Schlapbach, Kristen S. Gibbons, Stephen B. Horton, et al JAMA. Published online June 27, 2022. doi:10.1001/jama.2022.9376 Key Points Question  Does nitric oxide applied i...

Editorials Politics and mortality in the United States Steven Woolf BMJ 2022; 377 doi: https://doi.org/10.1136/bmj.o1308 (Published 07 June 2022)Cite this as: BMJ 2022;377:o1308 Mounting evidence suggests a link between republican politics and higher death rates For decades, people in the US have experienced lower life expectancy and poorer health outcomes than populations in other high income countries, and the problem has worsened over time.1 This pe...

Research Industry sponsorship bias in cost effectiveness analysis: registry based analysis Feng Xie, Ting Zhou BMJ 2022; 377 doi: https://doi.org/10.1136/bmj-2021-069573 (Published 22 June 2022)Cite this as: BMJ 2022;377:e069573 Abstract Objective To assess the association between industry sponsorship (drug, medical device, and biotechnology companies) and cost effectiveness results in cost effectiveness analysis (CEA). Design Registry based an...

ICU Management & Practice, Volume 22 - Issue 1, 2022 Diagnostic and Prognostic Value of Estimated Plasma Volume Status An overview of estimated plasma volume (ePVS), recent evidence supporting the association of ePVS with clinical congestion and whether it can help improve outcomes in patients with heart failure (HF). Plasma volume (PV) is the level of intravascular fluid minus the red blood cells, white blood cells and platelets. PV in heart failure (HF...

Brief Report  November 19, 2020 Eye Protection for Patients With COVID-19 Undergoing Prolonged Prone-Position Ventilation Lucy Sun, Maggie Hymowitz, Howard D. Pomeranz JAMA Ophthalmol. 2021;139(1):109-112. doi:10.1001/jamaophthalmol.2020.4988 Key Points Question  What ophthalmic abnormalities are present in patients with coronavirus disease 2019 in the intensive care unit requiring prolonged prone-position ventilation? Findings &nb...

Research Special Paper Political environment and mortality rates in the United States, 2001-19: population based cross sectional analysis Haider J Warraich, Pankaj Kumar, Khurram Nasir, et al BMJ 2022; 377 doi: https://doi.org/10.1136/bmj-2021-069308 (Published 07 June 2022)Cite this as: BMJ 2022;377:e069308 Abstract Objective To assess recent trends in age adjusted mortality rates (AAMRs) in the United States based on county level presidential vo...

Drug Dosing Recommendations for Obese COVID-19 Patients Obesity is highly prevalent in patients who are hospitalised with COVID-19. It is a widely recognised risk factor for severe COVID-19 infection with a greater risk for mortality compared with non-obese patients. With each 1 kg/m2 increase in body mass index, the risk for severe infection increases by 9% and mortality by 6%.  While there are evidence-basedevidence-based guidelines to treat patients...

ARTICLES| VOLUME 399, ISSUE 10344, P2351-2380, JUNE 25, 2022 Estimating global, regional, and national daily and cumulative infections with SARS-CoV-2 through Nov 14, 2021: a statistical analysis COVID-19 Cumulative Infection Collaborators Lancet 2022; 399: 2351-2380 Published:April 08, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)00484-6 Summary Background Timely, accurate, and comprehensive estimates of SARS-CoV-2 daily infection ra...

Medical News & Perspectives  June 1, 2022 Challenges of Deciding Whether and How to Update COVID-19 Vaccines to Protect Against Variants Rita Rubin JAMA. Published online June 1, 2022. doi:10.1001/jama.2022.9367 Seasonal influenza vaccines are updated every year, depending on what strains are circulating globally, leaving many people—especially those who still contracted COVID-19 after 2 booster shots—wondering why vaccines against SARS-C...