Original Investigation  August 9, 2022 Effect of Stenting Plus Medical Therapy vs Medical Therapy Alone on Risk of Stroke and Death in Patients With Symptomatic Intracranial Stenosis: The CASSISS Randomized Clinical Trial Peng Gao, Tao Wang, Daming Wang, et al; for the CASSISS Trial Investigators JAMA. 2022;328(6):534-542. doi:10.1001/jama.2022.12000 Key Points Question  Among patients with transient ischemic attack or ischemic s...

Nurse Staffing and Mortality Risk of Sepsis Sepsis is one of the most challenging complications in the ICU. It is a physiologic response to infection that could lead to multiorgan failure and death if not managed and treated properly. Sepsis is a major health issue in the U.S., with more than 1.7 million cases diagnosed annually. Sepsis is also a leading cause of death and one of the most expensive conditions treated by hospitals.  The treatment of sepsis h...

Original Investigation  April 29, 2022 Comparison of Home Antigen Testing With RT-PCR and Viral Culture During the Course of SARS-CoV-2 Infection Victoria T. Chu, Noah G. Schwartz, Marisa A. P. Donnelly, et al, for the COVID-19 Household Transmission Team JAMA Intern Med. 2022;182(7):701-709. doi:10.1001/jamainternmed.2022.1827 Key Points Question  How does the diagnostic performance of home antigen tests change during the course of SA...

Original Investigation  June 27, 2022 Temporal Trends in Antimicrobial Prescribing During Hospitalization for Potential Infection and Sepsis Hallie C. Prescott, Sarah Seelye, Xiao Qing Wang, et al JAMA Intern Med. Published online June 27, 2022. doi:10.1001/jamainternmed.2022.2291 Key Points Question  Is shortening the time to treatment for sepsis associated with increasing antimicrobial use, days of therapy, and broadness of cov...

Articles Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial Urs Fischer, Johannes Kaesmacher, Daniel Strbian, et al Lancet 2022; 400: 104-115 Summary Background Whether thrombectomy alone is equally as effective as intravenous alteplase plus thrombectomy remains controversial. We aimed to determine whether thrombectomy alone would ...

Articles Endovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4·5 h of stroke onset: an open-label, blinded-endpoint, randomised non-inferiority trial Peter J Mitchell, Bernard Yan, Leonid Churilov, et al Lancet 2022; 400: 116-125 https://doi.org/10.1016/S0140-6736(22)00564-5 Summary Background The benefit of combined treatment with intravenous thrombolysis before endovascular thrombectom...

CORRESPONDENCE Omicron SARS-CoV-2 Neutralization from Inactivated and ZF2001 Vaccines Xin Zhao, Rong Zhang, Shitong Qiao, et al N Engl J Med July 6, 2022DOI: 10.1056/NEJMc2206900 TO THE EDITOR: In the third year of the coronavirus disease 2019 (Covid-19) pandemic, the omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has swept the globe and yielded several subvariants.1,2 Currently, BA.2 is overtaking BA.1 in frequency. In addi...

Research Long distance airborne transmission of SARS-CoV-2: rapid systematic review Daphne Duval, Jennifer C Palmer, Isobel Tudge, et al BMJ 2022; 377 doi: https://doi.org/10.1136/bmj-2021-068743 (Published 29 June 2022)Cite this as: BMJ 2022;377:e068743 Abstract Objectives To evaluate the potential for long distance airborne transmission of SARS-CoV-2 in indoor community settings and to investigate factors that might influence transmission. Design&...

CORRESPONDENCE Duration of Shedding of Culturable Virus in SARS-CoV-2 Omicron (BA.1) Infection Julie Boucau, Caitlin Marino, James Regan, et al N Engl J Med June 29, 2022DOI: 10.1056/NEJMc2202092 TO THE EDITOR: The B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a shorter incubation period and a higher transmission rate than previous variants.1,2 Recently, the Centers for Disease Control and Prevention re...

ARTICLES|ONLINE FIRST Outcomes of flucytosine-containing combination treatment for cryptococcal meningitis in a South African national access programme: a cross-sectional observational study Rudzani C Mashau, Susan T Meiring, Vanessa C Quan, et al Lancet Infect Dis Published:June 21, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00234-1 Summary Background Although flucytosine is a key component of WHO-recommended induction treatment for HIV-asso...