Original Investigation  July 11, 2022 Association of Sociodemographic Characteristics With US Medical Student Attrition Mytien Nguyen,Sarwat I. Chaudhry, Mayur M. Desai, et al JAMA Intern Med. 2022;182(9):917-924. doi:10.1001/jamainternmed.2022.2194 Key Points Question  How do the medical student attrition rates compare across racial, ethnic, and socioeconomic identities? Findings  In this cohort study of 33 389 allopathic doc...

ICU Management & Practice, Volume 22 - Issue 2, 2022 ICU Management of the Very Old: The Evidence Base Anno 2022 This overview explores the publications concerning the very old ICU patients since 2011 and with a focus on publications from the VIP network on elderly COVID-19 patients. Introduction In 2017, an international group of intensivists with a particular interest for geriatric intensive care published a statement paper (Flaatten et al. 2017). T...

Original Investigation  July 18, 2022 Clinical Outcomes and Cost Associated With an Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump in Patients Presenting With Acute Myocardial Infarction Complicated by Cardiogenic Shock P. Elliott Miller, MD, Samantha G. Bromfield, Qinli Ma, et al JAMA Intern Med. 2022;182(9):926-933. doi:10.1001/jamainternmed.2022.2735 Key Points Question  Is there a difference in sho...

Editorials Can vitamin D protect against covid-19? Peter Bergman BMJ 2022; 378 doi: https://doi.org/10.1136/bmj.o1822 (Published 07 September 2022)Cite this as: BMJ 2022;378:o1822 Two new trials find no effect, but aren’t the final word Vitamin D is an important regulator of calcium balance. In addition, it has important effects on the immune system, directly inducing antimicrobial peptides at mucosal surfaces and modulating the function of T cells.12Observ...

#ISICEM22: The Place of Antiplatelet Agents in COVID-19 (REMAP-CAP Trial) Thrombotic events are common in patients hospitalised with COVID-19. Platelet activation has been implicated in the COVID-19 inflammatory response. However, the efficacy of antiplatelet therapy in critically ill patients with COVID-19 is still uncertain.  The Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP) trial aimed to answer...

Research Prevention of covid-19 and other acute respiratory infections with cod liver oil supplementation, a low dose vitamin D supplement: quadruple blinded, randomised placebo controlled trial Sonja H Brunvoll, Anders B Nygaard, Merete Ellingjord-Dale, et al BMJ 2022; 378 doi: https://doi.org/10.1136/bmj-2022-071245 (Published 07 September 2022)Cite this as: BMJ 2022;378:e071245 Abstract Objective To deter...

Original Investigation  September 8, 2022 Five-Year Outcomes in Patients With Fully Magnetically Levitated vs Axial-Flow Left Ventricular Assist Devices in the MOMENTUM 3 Randomized Trial Mandeep R. Mehra, Daniel J. Goldstein, Joseph C. Cleveland, et al JAMA. Published online September 8, 2022. doi:10.1001/jama.2022.16197 Key Points Question  In patients with advanced heart failure, what is the difference in the composite end poi...

Research Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT) David A Jolliffe, Hayley Holt, Matthew Greenig, et al BMJ 2022; 378 doi: https://doi.org/10.1136/bmj-2022-071230 (Published 07 September 2022)Cite this as: BMJ 2022;378:e071230 Abstract Objective To determine the effect of population level implementation of a test-...

ICU Management & Practice, Volume 22 - Issue 2, 2022 Understanding Carbon Dioxide in Resuscitation Peri-arrest CO2 measurement may serve to assess resuscitation efficacy and guide clinical decisions. This paper reviews current knowledge and future research directions for CO2 measurement and clinical application during CPR. Carbon Dioxide During Normal Heart-Lung Function CO2 is produced by the mitochondria as a major end product of tiss...

Original Investigation  August 26, 2022 Concordance of SARS-CoV-2 Results in Self-collected Nasal Swabs vs Swabs Collected by Health Care Workers in Children and Adolescents Jesse J. Waggoner, Miriam B. Vos, Erika A. Tyburski, et al JAMA. Published online August 26, 2022. doi:10.1001/jama.2022.14877 Key Points Question  Are children and adolescents, aged 4 to 14 years, able to adequately self-collect nasal swabs for SARS-CoV-2 te...