Original Investigation  July 19, 2022 Effect of Omecamtiv Mecarbil on Exercise Capacity in Chronic Heart Failure With Reduced Ejection Fraction: The METEORIC-HF Randomized Clinical Trial Gregory D. Lewis, Adriaan A. Voors, Alain Cohen-Solal, et al JAMA. 2022;328(3):259-269. doi:10.1001/jama.2022.11016 Key Points Question  Does omecamtiv mecarbil, a novel cardiac myosin activator, improve exercise capacity in patients with heart f...

ICU Management & Practice, Volume 22 - Issue 3, 2022 Practical Implementation of the Pancreatic Stone Protein Sepsis Test An overview of a discussion on sepsis and the Pancreatic Stone Protein (PSP) biomarker by Dr João Pereira, Hospital De Vila Franca De Xira, Portugal and how it can be used for early diagnosis of sepsis and facilitate decision-making regarding the administration of antibiotics. The discussion was chaired by Prof Pedro Póvoa, coordinator o...

CHEST INFECTIONS: ORIGINAL RESEARCH| VOLUME 161, ISSUE 5, P1201-1210, MAY 01, 2022 Primary Prophylaxis for Pneumocystis jirovecii Pneumonia in Patients Receiving Rituximab Jun Won Park, Jeffrey R. Curtis, Kang Il Jun, et al Chest 2022; 161: 1201-1210 Background Although previous studies suggested that rituximab increases the risk of Pneumocystis jirovecii pneumonia (PJP), it is uncertain whether its primary prophylaxis for PJP is ju...

ARTICLES| VOLUME 3, ISSUE 6, E443-E451, JUNE 01, 2022 Gut colonisation by extended-spectrum β-lactamase-producing Escherichia coli and its association with the gut microbiome and metabolome in Dutch adults: a matched case-control study Quinten R Ducarmon, Romy D Zwittink, Roel P J Willems, et al. Lancet Microbe 2022; 3: E443-E451 Published:April 20, 2022 DOI:https://doi.org/10.1016/S2666-5247(22)00037-4 Summary Background Gut colonisati...

ORIGINAL ARTICLE Trial of Erythropoietin for Hypoxic–Ischemic Encephalopathy in Newborns Yvonne W. Wu, Bryan A. Comstock, Fernando F. Gonzalez, et al N Engl J Med 2022; 387:148-159DOI: 10.1056/NEJMoa2119660 Abstract BACKGROUND Neonatal hypoxic–ischemic encephalopathy is an important cause of death as well as long-term disability in survivors. Erythropoietin has been hypothesized to have neuroprotective effects in infants with hypoxic–ischemic encephalopa...

ORIGINAL ARTICLE Maternal Vaccination and Risk of Hospitalization for Covid-19 among Infants Natasha B. Halasa, Samantha M. Olson, Mary A. Staat, et al N Engl J Med 2022; 387:109-119DOI: 10.1056/NEJMoa2204399 Abstract BACKGROUND Infants younger than 6 months of age are at high risk for complications of coronavirus disease 2019 (Covid-19) and are not eligible for vaccination. Transplacental transfer of antibodies against severe acute respiratory syndrome ...

ICU Management & Practice, Volume 22 - Issue 3, 2022 Sedation, Analgesia and Respiratory Drive in Mechanically Ventilated Adults An overview of the cardiovascular and respiratory effects of sedative agents commonly used in the ICU, emerging concepts of mechanical ventilation induced injury to the respiratory muscles and evolving concepts for sedation monitoring and sedation minimisation to achieve the goal of expeditious liberation from mechanical ventilati...

Research Letter  June 29, 2022 Internet Searches for Abortion Medications Following the Leaked Supreme Court of the United States Draft Ruling Adam Poliak, Nora Satybaldiyeva, Steffanie A. Strathdee, et al JAMA Intern Med. Published online June 29, 2022. doi:10.1001/jamainternmed.2022.2998 On May 2, 2022, a draft Supreme Court of the United States (SCOTUS) majority opinion was leaked,1 foreshadowing the decision to overturn the 1973 ...

PULMONARY VASCULAR: GUIDELINES AND CONSENSUS STATEMENTS| VOLUME 162, ISSUE 1, P213-225, JULY 01, 2022 Thromboprophylaxis in Patients With COVID-19: A Brief Update to the CHEST Guideline and Expert Panel Report Lisa K. Moores, Tobias Tritschler, Shari Brosnahan, et al Chest 2022; 162: 213-225 Published:February 12, 2022 DOI:https://doi.org/10.1016/j.chest.2022.02.006 Background Patients hospitalized with COVID-19 often exhibit markers of a ...

ICU Management & Practice, Volume 22 - Issue 3, 2022 Nutrition Monitoring and Patient Data Management Systems An overview of nutritional targets and their impact on critically ill patients and the need to use a systematic approach to nutritional support for optimal patient outcomes. Critically ill patients are often hypermetabolic and catabolic and are at a higher risk of underfeeding. Nutritional support for these patients can prevent energy deficits an...