Research Christmas 2022: Physical A Christmas themed physical activity intervention to increase participation in physical activity during Advent: pilot randomised controlled trial Gregory J H Biddle, James P Sanders, Kajal Gokal, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072807 (Published 19 December 2022)Cite this as: BMJ 2022;379:e072807 Abstract Objectives To examine the recruitment, retention, and preliminary effects of a Chris...

Research Christmas 2022: The Scientist Evaluation of editors’ abilities to predict the citation potential of research manuscripts submitted to The BMJ: a cohort study Sara Schroter, Wim E J Weber, Elizabeth Loder, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-073880 (Published 14 December 2022)Cite this as: BMJ 2022;379:e073880 Abstract Objective To evaluate the ability of The BMJ editors to predict the number of times s...

ARTICLES|ONLINE FIRST Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019 GBD 2019 Antimicrobial Resistance Collaborators Lancet Published: November 21, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)02185-7 Summary Background Reducing the burden of death due to infection is an urgent global public health priority. Previous studies have estimated the number of deaths associ...

Capnodynamic Monitoring to Assess PEEP in COVID-19 Optimal positive end-expiratory pressure (PEEP) level during mechanical ventilation for COVID-19 pneumonia remains debated. A third of experts in a recent consensus statement supported a low-level PEEP for COVID-19-related acute respiratory failure (C-ARDS), with half of the panel remaining neutral without agreement on PEEP titration. However, the Surviving Sepsis Campaign guideline recommends using high level of P...

Research Angiotensin receptor blockers for the treatment of covid-19: pragmatic, adaptive, multicentre, phase 3, randomised controlled trial Meg J Jardine, Sradha S Kotwal, Abhinav Bassi, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072175 (Published 16 November 2022)Cite this as: BMJ 2022;379:e072175 Abstract Objective To determine whether disrupting the renin angiotensin system with angiotensin receptor blockers will improve clinical out...

Pancreatic Stone Protein Testing Reduces Expenditure in Sepsis Sepsis is a life-threatening organ dysfunction and a cause of significant morbidity and mortality. In addition, the high number of sepsis cases is a significant economic burden for healthcare systems. Statistics show that sepsis was the most expensive condition treated in the U.S. in 2013, costing nearly $24 billion. An analysis of Medicare claims in 2020 found a 40% increase in sepsis-related hospital ...

ARTICLES| VOLUME 10, ISSUE 11, P1061-1073, NOVEMBER 01, 2022 Onset and window of SARS-CoV-2 infectiousness and temporal correlation with symptom onset: a prospective, longitudinal, community cohort study Seran Hakki, Jie Zhou, Jakob Jonnerby, et al Lancet Respir Med 2022; 10: 1061-1073 Published:August 18, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00226-0 Summary Background Knowledge of the window of SARS-CoV-2 infectiousness is cr...

ARTICLES| VOLUME 10, ISSUE 11, P1038-1048, NOVEMBER 01, 2022 Incidence of death or disability at 6 months after extracorporeal membrane oxygenation in Australia: a prospective, multicentre, registry-embedded cohort study Carol L Hodgson, Alisa M Higgins, Michael J Bailey, et al Lancet Respir Med Published:September 26, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00248-X Summary Background Extracorporeal membrane oxygenation (ECMO) is...

ARTICLES| VOLUME 22, ISSUE 11, P1626-1647, NOVEMBER 01, 2022 Age–sex differences in the global burden of lower respiratory infections and risk factors, 1990–2019: results from the Global Burden of Disease Study 2019 GBD 2019 LRI Collaborators Lancet Infect Dis 2022; 11: 1626-1647 Published:August 11, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00510-2 Summary Background The global burden of lower respiratory infections (LRIs) and cor...

ICU Management & Practice, Volume 21 - Issue 3, 2021 Oxygen Therapy in COVID-19 Patients: The Role of HFNC and CPAP Oxygen therapy and mechanical ventilation in patients with COVID-19 and steps to choose the right therapeutic strategy for each patient. Introduction Severe acute respiratory syndrome coronavirus CoV-2 is the highly contagious viral agent responsible for the ongoing COVID-19 pandemic. COVID-19 is the name of the syndrome caused by SARS-C...