ICU Management & Practice, Volume 22 - Issue 3, 2022 Analgesia, Sedation and Neuromuscular Blockade in Critically Ill Patients A Practical Approach for Intensivists A practical approach to analgesia, sedation and neuromuscular blockade of critically ill patients and a discussion on potential benefits, adverse effects and current professional international recommendations. Introduction Patients hospitalised in the Intensive Care Unit (ICU) are natur...

β-Lactam–Resistant Streptococcus pneumoniae Dynamics Following Treatment: A Dose-Response Meta-analysis  Matas Griskaitis,  Luis Furuya-Kanamori,  Kasim Allel,  et al Clinical Infectious Diseases, Volume 75, Issue 11, 1 December 2022, Pages 1962–1970, https://doi.org/10.1093/cid/ciac293 Abstract Background Patient exposure to antibiotics promotes the emergence of drug-resistant pathogens. The aim of this study was to identify whether the temporal dynamics o...

Research Oxygen administration during surgery and postoperative organ injury: observational cohort study David R McIlroy, Matthew S Shotwell, Marcos G Lopez, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-070941 (Published 30 November 2022)Cite this as: BMJ 2022;379:e070941 Abstract Objective To examine whether supraphysiological oxygen administration during surgery is associated with lower or higher postoperative kidney, heart, and lung inj...

Endgames Christmas 2022: Brain Stew Misspelling of antimicrobials by healthcare professionals Daniel Weiand, Joanna Lumb BMJ 2022; 379 doi: https://doi.org/10.1136/bmj.o2946 (Published 19 December 2022)Cite this as: BMJ 2022;379:o2946 Although electronic health records have widely reduced medication errors, and computerised hospital orders are an undeniable step-up in clarity from illegible handwritten orders,1234 they are not a patient safety panace...

The Influence of COVID-19 on Intensivist Wellbeing The COVID-19 pandemic has been challenging for healthcare systems around the world. In particular, the pandemic has resulted in critical care staffing shortages and has affected the quality of care.  In this review, the researchers examine the emergency response of hospitals to the pandemic and how it influenced the well-being of frontline intensivists. They also discuss potential strategies to improve inte...

Prevalence and Mechanisms of Mucus Accumulation in COVID-19 Lung Disease Takafumi Kato,  Takanori Asakura,  Caitlin E. Edwards, et al Am J Respir Crit Care Med 2022 Dec 1;206(11):1336-1352. doi: 10.1164/rccm.202111-2606OC Abstract Rationale: The incidence and sites of mucus accumulation and molecular regulation of mucin gene expression in coronavirus (COVID-19) lung disease have not been reported. Objectives: To characterize the incidence of mu...

Research Christmas 2022: Physical Quantifying the benefits of inefficient walking: Monty Python inspired laboratory based experimental study Glenn A Gaesser, David C Poole, Siddhartha S Angadi BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072833 (Published 21 December 2022)Cite this as: BMJ 2022;379:e072833 Abstract Objective To compare the rate of energy expenditure of low efficiency walking with high efficiency walking. Design Labo...

Sex Differences in Mortality of ICU Patients According to Diagnosis-related Sex Balance Lucy J. Modra,  Alisa M. Higgins,  David V. Pilcher, et al Am J Respir Crit Care Med 2022 Dec 1;206(11):1353-1360. doi: 10.1164/rccm.202203-0539OC. Abstract Rationale: Women have worse outcomes than men in several conditions more common in men, including cardiac surgery and burns. Objectives: To describe the relationship between sex balance within each diagnost...

Research Christmas 2022: Physical Digital disparities among healthcare workers in typing speed between generations, genders, and medical specialties: cross sectional study Alex R Schuurman, M E Baarsma, W Joost Wiersinga, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072784 (Published 19 December 2022)Cite this as: BMJ 2022;379:e072784 Abstract Objective To investigate the typing skills of healthcare professionals. Design Cross...

Research Christmas 2022: Don’t Believe the Hype Everything causes cancer? Beliefs and attitudes towards cancer prevention among anti-vaxxers, flat earthers, and reptilian conspiracists: online cross sectional survey Sonia Paytubi, Yolanda Benavente, Alexandra Montoliu, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072561 (Published 21 December 2022)Cite this as: BMJ 2022;379:e072561 Abstract Objective To evaluate, using an online non-p...