Original Investigation  August 16, 2022 Effect of Remote Ischemic Conditioning vs Usual Care on Neurologic Function in Patients With Acute Moderate Ischemic Stroke: The RICAMIS Randomized Clinical Trial Hui-Sheng Chen, Yu Cui, Xiao-Qiu Li, et al JAMA. 2022;328(7):627-636. doi:10.1001/jama.2022.13123 Key Points Question  Does remote ischemic conditioning, which involves repeated occlusion/release cycles on bilateral upper limb art...

ORIGINAL ARTICLEFREE PREVIEW Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis Enrique de-Madaria, James L. Buxbaum, Patrick Maisonneuve, et al N Engl J Med 2022; 387:989-1000DOI: 10.1056/NEJMoa2202884 Abstract BACKGROUND Early aggressive hydration is widely recommended for the management of acute pancreatitis, but evidence for this practice is limited. METHODS At 18 centers, we randomly assigned patients who presented with acute pan...

Editorial  August 16, 2022 Remote Ischemic Conditioning: Feasible and Potentially Beneficial for Ischemic Stroke David C. Hess, Rolf A. Blauenfeldt, Grethe Andersen JAMA. 2022;328(7):622-624. doi:10.1001/jama.2022.13365 Stroke is the second leading cause of death and disability in the world.1 In 1996, tissue plasminogen activator (tPA) was approved by the US Food and Drug Administration and remains the only approved pharmacologic agent f...

Editorial  August 9, 2022 Therapeutic Strategies for Intracranial Atherosclerosis Craig S. Anderson, Lili Song, Jianmin Liu JAMA. 2022;328(6):529-531. doi:10.1001/jama.2022.11525 Intracranial atherosclerosis (ICAS) is a major cause of stroke worldwide. Although approximately 12% of White patients with a history of acute ischemic stroke or transient ischemic attack (TIA) have some form of ICAS detected on routine screening in predominantly old...

#EA22: Long-Term Exposure to Air Pollution Increases Risk of Severe COVID-19 New research presented at Euroanaesthesia 2022 finds that long-term exposure to air pollution is linked to a greater risk of severe COVID-19. Findings from the study show that people living in counties with higher levels of nitrogen dioxide (NO2) were more likely to need ICU care and mechanical ventilation if they had COVID-19. Long-term exposure to NO2 can have harmful effects on ...

Editorial  September 6, 2022 Clinical Decision Support to Prevent Acute Kidney Injury After Cardiac Catheterization: Moving Beyond Process to Improving Clinical Outcomes Eric R. Gottlieb, Mallika Mendu JAMA. 2022;328(9):831-832. doi:10.1001/jama.2022.14070 Over the past decade, with the advent of meaningful use as part of the 2009 Health Information Technology for Economic and Clinical Health (HITECH) Act, the US health care system has experi...

Original Investigation  August 9, 2022 Effect of Intravenous Tirofiban vs Placebo Before Endovascular Thrombectomy on Functional Outcomes in Large Vessel Occlusion Stroke: The RESCUE BT Randomized Clinical Trial RESCUE BT Trial Investigators JAMA. 2022;328(6):543-553. doi:10.1001/jama.2022.12584 Key Points Question  Among patients with large vessel occlusion acute ischemic stroke, does administration of intravenous tirofiban befo...

Research Risk of covid-19 related deaths for SARS-CoV-2 omicron (B.1.1.529) compared with delta (B.1.617.2): retrospective cohort study Isobel L Ward, Charlotte Bermingham, Daniel Ayoubkhani, et al BMJ 2022; 378 doi: https://doi.org/10.1136/bmj-2022-070695 (Published 02 August 2022)Cite this as: BMJ 2022;378:e070695 Abstract Objective To assess the risk of covid-19 death after infection with omicron BA.1 compared with delta (B.1.617.2). Design ...

#EA22: Impact of Fatigue on Doctors and Nurses Consultant Anaesthetist Dr Nancy Redfern of Newcastle Hospitals NHS Foundation Trust, Newcastle, U.K., presented a review at Euroanaesthesia 2022 highlighting the potentially lethal effects of fatigue on doctors and nurses, its impact on the quality of their clinical work and judgement and its subsequent impact on patient safety. According to Dr Redfern, healthcare systems need to have formal risk management systems...

Research Waning effectiveness of BNT162b2 and ChAdOx1 covid-19 vaccines over six months since second dose: OpenSAFELY cohort study using linked electronic health records Elsie M F Horne, William J Hulme, Ruth H Keogh, et al BMJ 2022; 378 doi: https://doi.org/10.1136/bmj-2022-071249 (Published 20 July 2022)Cite this as: BMJ 2022;378:e071249 Abstract Objective To estimate waning of covid-19 vaccine effectiveness over six months after second dose. Desi...