Reversing Sepsis-Induced Hypotension Sepsis is characterised by hypovolaemia and vasodilation. It is also characterised by organ dysfunction secondary to a dysregulated immune response of the host to the microbial pathogen. Prompt identification, early treatment with appropriate antibiotics, and fluid resuscitation can improve patient outcomes. Patients with cirrhosis and sepsis are a distinct group. The haemodynamic alterations are more profound in these patients ...

Editor's Note  November 28, 2022 The Uncertain Effects of Surveillance Screening for COVID-19 for Individuals Entering Health Care Facilities Eric Ward, Mitchell H. Katz JAMA Intern Med. Published online November 28, 2022. doi:10.1001/jamainternmed.2022.5429 Entrance surveillance screenings have been widely implemented in health care settings during the COVID-19 pandemic. These measures, which are required by the US Department of Labor,1 ...

RTICLES|ONLINE FIRST Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial Christopher C Butler, F D Richard Hobbs, Oghenekome A Gbinigie, et al Lancet AccessPublished:December 22, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)02597-1 Summary Background The safety, effectiveness, and cost-effective...

ICU Management & Practice, Volume 22 - Issue 3, 2022 Pain Management in Paediatric Critical Care An overview of the main treatment options currently available in paediatric critical care setting. Critically ill paediatric patients often suffer from pain secondary to trauma, complex medical procedures, invasive testing monitoring devices and illness-induced discomfort. Although the gold standard for assessing patient comfort is self-report, in paediatrics...

Original Investigation  September 21, 2022 Operative vs Nonoperative Treatment of Acute Unstable Chest Wall Injuries: A Randomized Clinical Trial Niloofar Dehghan, Aaron Nauth, Emil Schemitsch, et al JAMA Surg. 2022;157(11):983-990. doi:10.1001/jamasurg.2022.4299 Question  Does surgical treatment of unstable chest wall injuries improve ventilator-free days and outcomes compared to nonoperative treatment? Findings  In this randomi...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalImpact of renal-replacement therapy strategies on outcomes for patients with chronic kidney disease: a secondary analysis of the STARRT-AKI trialBagshaw S.M. et al.OPEN ACCESS ~ OriginalModel-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients: a multicentre randomised clinical trialEwoldt T.M.J. et al.Impact of BMI on outcomes in respiratory ECMO: an ELSO registry study...

Original Investigation  November 30, 2022 Association Between Hemorrhage Control Interventions and Mortality in US Trauma Patients With Hemodynamically Unstable Pelvic Fractures Tanya Anand, Khaled El-Qawaqzeh, Adam Nelson, et al JAMA Surg. Published online November 30, 2022. doi:10.1001/jamasurg.2022.5772 Question  What is the current variation in nationwide practices for the management of pelvic fracture–related hemorrhage? Fin...

ICU Management & Practice, Volume 22 - Issue 3, 2022 Perioperative Haemodynamic Optimisation of the High-Risk Surgical Patient An overview of evidence supporting perioperative haemodynamic optimisation in high-risk surgery patients and strategies to facilitate its implementation and adoption to improve patient outcomes. A million surgical procedures performed every year worldwide are at risk of complications that can be attributed to the nature of the su...

Research Letter  November 28, 2022 Analysis of Failure Rates for COVID-19 Entrance Screening at a US Academic Medical Center Scott C. Roberts, Ridwan N. Faruq, Anne K. Wilkinson, et al JAMA Intern Med. Published online November 28, 2022. doi:10.1001/jamainternmed.2022.5426 Many health care facilities use entrance screening to prevent individuals with acute COVID-19 from entering. In ambulatory settings, 1 study found failures (defined as an e...

Editorials Oxygen administration during general anaesthesia for surgery Michele Samaja, Davide Chiumello BMJ 2022; 379 doi: https://doi.org/10.1136/bmj.o2823 (Published 30 November 2022)Cite this as: BMJ 2022;379:o2823 Oxygen can be a double edged sword Oxygen is routinely administered to almost all patients undergoing general anaesthesia,1 to ensure adequate oxygenation from intubation until awakening—the period when complications due to hypoxaemia ar...