Rapid ICU Upskilling Delivers High ROI  In ICU Mon, 28 Jul 2025 In the face of large-scale healthcare crises, intensive care units (ICUs) must quickly expand their capacity to meet surging demand. Traditional responses—such as increasing bed numbers or reallocating resources—are often hampered by a fundamental limitation: the availability of trained personnel. Lengthy, resource-intensive medical training pathways cannot produce ICU-ready professio...

ORIGINAL ARTICLE A Phase 3 Trial of Telitacicept for Systemic Lupus Erythematosus Ronald F. van Vollenhoven, Li Wang, Joan T. Merrill, et al N Engl J Med 2025;393:1475-1485 DOI: 10.1056/NEJMoa2414719 Abstract BACKGROUND Telitacicept, a new dual inhibitor of the cytokines B-lymphocyte stimulator (BLyS) and APRIL (a proliferation-inducing ligand), showed efficacy in adults with active systemic lupus erythematosus (SLE) in a phase 2b trial when added to ...

ARTICLES Global age-sex-specific all-cause mortality and life expectancy estimates for 204 countries and territories and 660 subnational locations, 1950–2023: a demographic analysis for the Global Burden of Disease Study 2023 GBD 2023 Demographics Collaborators Lancet 2025; 406: 1731-1810 DOI: 10.1016/S0140-6736(25)01330-3  Summary Background Comprehensive, comparable, and timely estimates of demographic metrics—including life expectancy and...

Editorial  An Oasis in the Platelet Desert? Matthew D. Neal, Philip C. Spinella, Lucy Z. Kornblith JAMA Published Online: December 8, 2025 doi: 10.1001/jama.2025.24442 A substantial proportion of the global population lacks reliable, timely access to platelet transfusions, largely due to constraints in donor supply and the inherently short shelf life of platelets. Even in high-income countries, including the US, platelet availability remains limited, a...

FICUS: Nurse-Led Family Support Intervention In ICU Wed, 6 Aug 2025 Family members of ICU patients often experience intense distress, uncertainty, and a high risk of postintensive care syndrome–family, with 20–30% reporting significant caregiver burden. They frequently lack adequate communication and support from ICU staff, contributing to negative experiences and poor health outcomes. While family-focused interventions, such as structured communicatio...

ARTICLES Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023 GBD 2023 Disease and Injury and Risk Factor Collaborators Lancet 2025; 406: 1873-1922 DOI: 10.1016/S0140-6736(25)01637-X Summary Background For more than three decades, the Global Bur...

Original Investigation  Caring for the Critically Ill Patient Cryopreserved vs Liquid-Stored Platelets for the Treatment of Surgical Bleeding: The CLIP-II Randomized Noninferiority Clinical Trial Michael C. Reade, Denese C. Marks, Belinda D. Howe, et al JAMA Published Online: December 8, 2025 doi: 10.1001/jama.2025.23355 Key Points Question  Are cryopreserved platelets less effective and safe than conventional liquid-stored platelets in...

Article Published: 28 September 2024 Effectiveness of influenza vaccines in preventing acute cardiovascular events within 1 year in Beijing, China Yuan Ma, Feng Lu, Luodan Suo, et al npj Vaccines 9, 177 (2024) https://doi.org/10.1038/s41541-024-00969-y Abstract Controversies persist about the protective effects of vaccines against acute cardiovascular events. Using electronic medical records from hospitals and influenza vaccine administration d...

Editorial  Automated Modes to Improve Mechanical Ventilation Outcomes—The Ghost in the Machine Michael C. Sklar, Niall D. Ferguson JAMA Published Online: December 8, 2025 doi: 10.1001/jama.2025.24401 Invasive mechanical ventilation, one of the defining interventions in critical care medicine, is received by more than 20 million patients annually in intensive care units (ICUs) worldwide.1 In any given ICU, usually half or more of patients require invasi...

Original Investigation  Caring for the Critically Ill Patient Effect of Automated Closed-Loop Ventilation vs Protocolized Conventional Ventilation on Ventilator-Free Days in Critically Ill Adults: A Randomized Clinical Trial Jante S. Sinnige, Laura A. Buiteman-Kruizinga, Janneke Horn, et al JAMA Published Online: December 8, 2025 doi: 10.1001/jama.2025.24384 Key Points Question  Among critically ill adults receiving invasive mechanical ...