Research Rivaroxaban treatment for six weeks versus three months in patients with symptomatic isolated distal deep vein thrombosis: randomised controlled trial Walter Ageno, Lorenza Bertù, Eugenio Bucherini, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072623 (Published 23 November 2022)Cite this as: BMJ 2022;379:e072623 Abstract Objective To compare two different treatment durations of rivaroxaban in patients with symptomatic isolated di...

CRT Kinetics After Fluid Infusion Peripheral tissue hypoperfusion is a strong predictor of poor outcomes in patients suffering from severe conditions, such as sepsis, cardiac arrest or cardiogenic shock. The evaluation of peripheral tissue perfusion is very important in identifying shock patients. This can be done at the bedside with either semi-quantitative tools such as the mottling score, or quantitative tools, such as skin temperature and the capillary refill t...

Research Global burden of type 2 diabetes in adolescents and young adults, 1990-2019: systematic analysis of the Global Burden of Disease Study 2019 Jinchi Xie, Maoqing Wang, Zhiping Long, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072385 (Published 07 December 2022)Cite this as: BMJ 2022;379:e072385 Abstract Objective To estimate the global burden of type 2 diabetes in adolescents and young adults (aged 15-39 years) from 1990 to 2019. ...

Editorials Awake prone positioning and covid-19 Amol A Verma, Fahad Razak, Laveena Munshi, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj.o2888 (Published 07 December 2022)Cite this as: BMJ 2022;379:o2888 Safely reduces intubation for patients with hypoxaemia In a linked paper, Weatherald and colleagues (doi:10.1136/bmj-2022-071966) offer the most up-to-date evidence synthesis evaluating the use of awake prone positioning in adults with covid-19 ...

Research Efficacy of awake prone positioning in patients with covid-19 related hypoxemic respiratory failure: systematic review and meta-analysis of randomized trials Jason Weatherald, Ken Kuljit S Parhar, Zainab Al Duhailib, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-071966 (Published 07 December 2022)Cite this as: BMJ 2022;379:e071966 Abstract Objective To determine the efficacy and safety of awake prone positioning versus usual care i...

Understanding “No Escalation of Treatment” Designations No Escalation of Treatment (NoET) designations are used in ICUs to limit treatment for critically ill patients. However, they are the subject of much debate and have not been qualitatively studied. In this study conducted at seven hospitals in the U.S., researchers evaluate how physicians understand and perceive NoET designations with regard to their utility and associated challenges. They also explore what...

Invited Commentary  September 18, 2022 Fluoroscopic Guidance for Femoral Artery Access—Pushing Patients Out of the Plane Without a Parachute? Alexander C. Fanaroff, Jay Giri JAMA Cardiol. 2022;7(11):1118-1120. doi:10.1001/jamacardio.2022.3413 Common femoral artery (CFA) access—for diagnostic angiography, percutaneous coronary intervention (PCI), or other endovascular or structural heart procedures—is among the most ubiquitous procedures performed in th...

ORIGINAL ARTICLE Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus Tim Hundscheid, Wes Onland, Elisabeth M.W. Kooi, et al N Engl J Med December 6, 2022DOI: 10.1056/NEJMoa2207418 Abstract BACKGROUND Cyclooxygenase inhibitors are commonly used in infants with patent ductus arteriosus (PDA), but the benefit of these drugs is uncertain. METHODS In this multicenter, noninferiority trial, we randomly assigned infants with echocardiogra...

Invasive Mechanical Ventilation and the Pulmonary Microbiota Healthy lungs are necessary to accomplish O2/CO2 exchange between blood and external air. The pulmonary microbiota is critical for maintaining the functional balance of the lungs and is associated with the development and progression of respiratory diseases, such as asthma, chronic obstructive pulmonary disease, cystic fibrosis (CF), non-CF bronchiectasis, tuberculosis, COVID-19, lung cancer and lung...

CORRESPONDENCE| VOLUME 23, ISSUE 1, P22-23, JANUARY 01, 2023 Omicron sublineage BQ.1.1 resistance to monoclonal antibodies Prerna Arora, Amy KempfInga, Nehlmeier Sebastian, et al. Lancet Infect Dis Published: November 18, 2022 DOI: https://doi.org/10.1016/S1473-3099(22)00733-2 Vaccination represents the key strategy to control the COVID-19 pandemic through induction of neutralising antibody responses and T cell-associated immunity that subst...