ORIGINAL ARTICLE Percutaneous Revascularization for Ischemic Left Ventricular Dysfunction Divaka Perera, Tim Clayton, Peter D. O’Kane, et al N Engl J Med August 27, 2022DOI: 10.1056/NEJMoa2206606 Abstract BACKGROUND Whether revascularization by percutaneous coronary intervention (PCI) can improve event-free survival and left ventricular function in patients with severe ischemic left ventricular systolic dysfunction, as compared with optimal medical thera...

ORIGINAL ARTICLE Oxygen Targets in Comatose Survivors of Cardiac Arrest Henrik Schmidt, Jesper Kjaergaard, Christian Hassager, et al N Engl J Med August 27, 2022DOI: 10.1056/NEJMoa2208686 Abstract BACKGROUND The appropriate oxygenation target for mechanical ventilation in comatose survivors of out-of-hospital cardiac arrest is unknown. METHODS In this randomized trial with a 2-by-2 factorial design, we randomly assigned comatose adults with out-of-...

ICU Management & Practice, Volume 22 - Issue 2, 2022 Challenges in the Haemodynamic Management of Septic Shock An overview of the haemodynamic management of patients in septic shock and strategies for detection of haemodynamic changes and appropriate therapeutic action to improve the prognosis of these patients. Introduction Sepsis is one of the main causes of admission to the Intensive Care Unit (ICU). It is defined as a life-threatening organ dysfun...

Invited Commentary  August 10, 2022 Expanding Options for Total Intravenous Anesthesia—The Etomidate vs Propofol for In-Hospital Complications Trial Jason M. Johanning JAMA Surg. Published online August 10, 2022. doi:10.1001/jamasurg.2022.3339 Using a randomized clinical trial design, the authors compared the ability of etomidate to provide total intravenous (IV) anesthesia with propofol.1 Propofol is the most common IV anesthesia medica...

ORIGINAL ARTICLE Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest Jesper Kjaergaard, Jacob E. Møller, Henrik Schmidt, et al N Engl J Med August 27, 2022DOI: 10.1056/NEJMoa2208687 Abstract BACKGROUND Evidence to support the choice of blood-pressure targets for the treatment of comatose survivors of out-of-hospital cardiac arrest who are receiving intensive care is limited. METHODS In a double-blind, randomized trial with a 2-by-2 facto...

ICU Management & Practice, Volume 22 - Issue 2, 2022 One Sepsis Fits All? Are There Different Phenotypes of Sepsis? Diagnostic Approaches and Therapies This article presents current research results in relation to an advanced sepsis classification and their implications for new treatment options and research strategies. Introduction Through history, the definition and the term sepsis changed. Since Semmelweis and others formulated the thesis that seps...

Original Investigation  August 10, 2022 Effect of Etomidate vs Propofol for Total Intravenous Anesthesia on Major Postoperative Complications in Older Patients: A Randomized Clinical Trial Zhihong Lu, Hong Zheng, Zhijun Chen, et al JAMA Surg. Published online August 10, 2022. doi:10.1001/jamasurg.2022.3338 Key Points Question  Does etomidate compared with propofol provide a noninferior effect on...

US Preventive Services Task Force  Recommendation Statement August 23/30, 2022 Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: US Preventive Services Task Force Recommendation Statement US Preventive Services Task Force JAMA. 2022;328(8):746-753. doi:10.1001/jama.2022.13044 Abstract Importance  Cardiovascular disease (CVD) is the leading cause of morbidity and death in the US and is the cause of more...

Original Investigation  August 17, 2022 Association of Prehospital Needle Decompression With Mortality Among Injured Patients Requiring Emergency Chest Decompression Daniel Muchnok, Allison Vargo, Andrew-Paul Deeb, et al JAMA Surg. Published online August 17, 2022. doi:10.1001/jamasurg.2022.3552 Key Points Question  Is prehospital needle decompression (PHND) associated with lower 24-hour mortality among trauma patients requiring ...

ICU Management & Practice, Volume 22 - Issue 3, 2022 Ten Overlooked Mistakes During Early Mobilisation in the Intensive Care Unit An overview of the most common mistakes in decision making and the practice of early mobilisation in the intensive care unit. Introduction Early mobilisation (EM) is a therapeutic strategy implemented to avoid and overcome impairments developed due to critical illness and ICU stay. Several benefits have been described throu...