Research Changing patterns in reporting and sharing of review data in systematic reviews with meta-analysis of the effects of interventions: cross sectional meta-research study Phi-Yen Nguyen, Raju Kanukula, Joanne E McKenzie, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072428 (Published 22 November 2022)Cite this as: BMJ 2022;379:e072428 Abstract Objectives To examine changes in completeness of reporting and frequency of sharing data, an...

ORIGINAL ARTICLE Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension The National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinical Trials Network N Engl J Med January 21, 2023DOI: 10.1056/NEJMoa2212663 Abstract BACKGROUND Intravenous fluids and vasopressor agents are commonly used in early resuscitation of patients with sepsis, but comparative data for prioritizing their delivery are l...

Research Impact of community asymptomatic rapid antigen testing on covid-19 related hospital admissions: synthetic control study Xingna Zhang, Ben Barr, Mark Green, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-071374 (Published 23 November 2022)Cite this as: BMJ 2022;379:e071374 Abstract Objective To analyse the impact of voluntary rapid testing for SARS-CoV-2 antigen in Liverpool city on covid-19 related hospital admissions. Design&nbs...

Vitamin D Supplements and Risk of COVID-19 Findings from two large clinical trials show that increasing vitamin D levels in adults during the COVID-19 pandemic was not associated with protection against coronavirus or other respiratory tract infections.  Vitamin D has long been recognised to support innate immune responses to respiratory viruses and bacteria. Some studies show that vitamin D may protect against respiratory tract infections, particularly amo...

ARTICLES| VOLUME 10, ISSUE 12, P1137-1146, DECEMBER 01, 2022 Anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19 (PANAMO): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial Alexander P J Vlaar, Martin Witzenrath, Pieter van Paassen, et al. Lancet Respir Med 2022; 10: 1137-1146 Published:September 07, 2022 DOI: https://doi.org/10.1016/S2213-2600(22)00297-1 ...

Editorial  December 16, 2022 Long-term Follow-up After Critical COVID-19: REMAP-CAP Revisited Michael L. Barnett, Paul E. Sax JAMA. Published online December 16, 2022. doi:10.1001/jama.2022.23700 The year 2020 was a grim and uncertain time for any clinician caring for inpatients with COVID-19, especially those with critical illness. In an era of modern medicine in which the range of options for many conditions can seem limitless, this novel v...

Research Letter  Climate Change and Health December 20, 2022 Association Between the 2021 Heat Wave in Portland, Oregon, and Seattle, Washington, and Emergency Department Visits Amruta Nori-Sarma, Chad Milando, Kate R. Weinberger, et al JAMA. 2022;328(23):2360-2362. doi:10.1001/jama.2022.20665 Heat waves are becoming more frequent and severe, with pronounced effects on human health.1 In late June 2021, temperatures in the US Pacific N...

ICU Professionals’ Knowledge of End-of-Life Decision-Making Law There are laws regulating healthcare practice at the end of life. Most healthcare professionals rely on their clinical knowledge to inform treatment decisions during this time. However, the extent to which the law informants their decision-making at the end of life remains uncertain.  In this study, the researchers describe what healthcare professionals in the ICU and emergency departments know...

JAMA Insights  Genomics and Precision Health December 16, 2022 RNA Sequencing as a Diagnostic Tool Shamika Ketkar, Lindsay C. Burrage, Brendan Lee JAMA. Published online December 16, 2022. doi:10.1001/jama.2022.22843 RNA sequencing (RNA-seq) is a new tool in the genetic diagnostic laboratory made possible by the advent of low-cost, high-throughput, next-generation sequencing technology. Historically, RNA studies were limited to g...

Original Investigation  Caring for the Critically Ill Patient December 16, 2022 Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial Writing Committee for the REMAP-CAP Investigators JAMA. Published online December 16, 2022. doi:10.1001/jama.2022.23257 Key Points Question  What is the effect of treatment for critically ill patients with COVID-19 on longer-term mortali...