ARTICLES|ONLINE FIRST The effect of higher protein dosing in critically ill patients with high nutritional risk (EFFORT Protein): an international, multicentre, pragmatic, registry-based randomised trial Daren K Heyland, Jayshil Patel, Charlene Compher, et al. Lancet Published:January 25, 2023 DOI:https://doi.org/10.1016/S0140-6736(22)02469-2 Summary Background On the basis of low-quality evidence, international critical care nutrition guidelines reco...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 162, ISSUE 5, P1063-1073, NOVEMBER 01, 2022 Outcomes and Predictors of 28-Day Mortality in Patients With Solid Tumors and Septic Shock Defined by Third International Consensus Definitions for Sepsis and Septic Shock Criteria John A. Cuenca, Nirmala K. Manjappachar, Claudia M. Ramírez, et al Chest 2022; 162: 1063-1073 Published:May 26, 2022 DOI:https://doi.org/10.1016/j.chest.2022.05.017 Background D...

Dexamethasone and Oxygen Support Strategies for COVID-19 Hypoxaemic Respiratory Failure Acute hypoxaemic respiratory failure (AHRF) is one of the main manifestations of severe COVID-19. The RECOVERY trial showed that dexamethasone 6 mg/d for ten days reduced 28-day mortality in patients with the most severe COVID-19. Another study described the benefit of high-dose dexamethasone in ARDS. However, Munch et al. found no difference between high-dose and low-dose dexam...

ORIGINAL ARTICLE Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest Martje M. Suverein, Thijs S.R. Delnoij, Roberto Lorusso, et al N Engl J Med 2023; 388:299-309DOI: 10.1056/NEJMoa2204511 Abstract BACKGROUND Extracorporeal cardiopulmonary resuscitation (CPR) restores perfusion and oxygenation in a patient who does not have spontaneous circulation. The evidence with regard to the effect of extracorporeal CPR on survival with a favorabl...

Research Retracted papers originating from paper mills: cross sectional study Cristina Candal-Pedreira, Joseph S Ross, Alberto Ruano-Ravina, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-071517 (Published 28 November 2022)Cite this as: BMJ 2022;379:e071517 Abstract Objectives To describe retracted papers originating from paper mills, including their characteristics, visibility, and impact over time, and the journals in which they were publi...

Remote Ischaemic Conditioning in Septic Shock Septic shock is one of the most severe complications of any infection. It affects millions of people each year. Studies show that in the U.S. and Europe, nearly 10% of patients admitted to the ICU have septic shock. Significant efforts have been made to recognise and treat septic shock early. Still, over 50% of patients die of septic shock within days or weeks after diagnosis. Thus, there is a need for new therapeutic a...

Surge Mechanical Ventilation During COVID-19 During the COVID-19 pandemic, many hospitals in the U.S. exceeded their mechanical ventilation capability. As COVID-19 spread to communities with limited immunity, challenges associated with providing surge mechanical ventilation were reported. Hospitals, healthcare systems, and jurisdictional authorities purchased more ventilators. But the fear that the supply would not be able to fulfill the demand conti...

ARTICLES|ONLINE FIRST Rituximab versus intravenous cyclophosphamide in patients with connective tissue disease-associated interstitial lung disease in the UK (RECITAL): a double-blind, double-dummy, randomised, controlled, phase 2b trial Toby M Maher, Veronica A Tudor, Peter Saunders, et al. Lancet Respir Med Published:November 11, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00359-9 Summary Background Rituximab is often used as rescue therapy in in...

Favipiravir for Treatment of Outpatients With Asymptomatic or Uncomplicated Coronavirus Disease 2019: A Double-Blind, Randomized, Placebo-Controlled, Phase 2 Trial  Marisa Holubar,  Aruna Subramanian,  Natasha Purington,  et al Clinical Infectious Diseases, Volume 75, Issue 11, 1 December 2022, Pages 1883–1892, https://doi.org/10.1093/cid/ciac312 Abstract Background Favipiravir, an oral, RNA-dependent RNA polymerase inhibitor, has in vitroactivity...

Clinical Nutrition Issues in 2022 Critically ill patients are fed with amounts below the recommendations of international guidelines. To overcome large energy deficits, supplemental parenteral nutrition (SPN) to top up enteral nutrition (EN) has been proposed. This strategy is included in both the American (ASPEN) and European (ESPEN) clinical nutrition guidelines.  SPN has demonstrated clinical benefits and is included in the American and European guidelin...