Original Published: 10 February 2023 Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study Alexis Tabah, Niccolò Buetti, Quentin Staiquly, et al Intensive Care Med (2023). https://doi.org/10.1007/s00134-022-06944-2 Abstract Purpose In the critically ill, hospital-acquired bloodstream infections (HA-BSI) are associated with significant mortality. Granular ...

Original Investigation  Less Is More September 19, 2022 Perioperative Gabapentin Use and In-Hospital Adverse Clinical Events Among Older Adults After Major Surgery Chan Mi Park, Sharon K. Inouye, Edward R. Marcantonio, et al JAMA Intern Med. 2022;182(11):1117-1127. doi:10.1001/jamainternmed.2022.3680 Key Points Question  Is perioperative gabapentin use associated with in-hospital adverse clinical events among older adults after maj...

EDITORIAL Improved Prospects for Thrombectomy in Large Ischemic Stroke Pierre Fayad N Engl J Med February 10, 2023DOI: 10.1056/NEJMe2300193 Mechanical endovascular thrombectomy, when performed within 24 hours after the onset of symptoms in patients with small-to-moderate acute ischemic strokes that are due to proximal occlusion of a large cerebral vessel, has been shown to result in rates of recanalization of 70 to 80% and to significantly improve functional i...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalLong-term outcomes of patients with COVID-19 treated with helmet noninvasive ventilation or usual respiratory support: follow-up study of the Helmet-COVID randomized clinical trialArabi Y.M. et al. Excess mortality among non-COVID-19 surgical patients attributable to the exposure of French intensive and intermediate care units to the pandemicDuclos A. et al. What's New in Intensive CareNeuromonitoring for prog...

ORIGINAL ARTICLE Trial of Endovascular Thrombectomy for Large Ischemic Strokes Amrou Sarraj, Ameer E. Hassan, Michael G. Abraham, et al N Engl J Med February 10, 2023DOI: 10.1056/NEJMoa2214403 Abstract BACKGROUND Trials of the efficacy and safety of endovascular thrombectomy in patients with large ischemic strokes have been carried out in limited populations. METHODS We performed a prospective, randomized, open-label, adaptive, international trial ...

ORIGINAL ARTICLE Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct Xiaochuan Huo, Gaoting Ma, Xu Tong, et al N Engl J Med February 10, 2023DOI: 10.1056/NEJMoa2213379 Abstract BACKGROUND The role of endovascular therapy for acute stroke with a large infarction has not been extensively studied in differing populations. METHODS We conducted a multicenter, prospective, open-label, randomized trial in China involving patients wi...

ICU Management & Practice, Volume 22 - Issue 4, 2022 Diagnostic Stewardship in Five Common Infectious Syndromes This article defines diagnostic stewardship and discusses how it can be implemented in intensive care units and how it may improve patient outcomes. Introduction Antimicrobial resistance (AMR) is an imminent threat to global health and has been accelerated by the inappropriate use of antimicrobials (Llor and Bjerrum 2014). Antimicrobial stew...

ORIGINAL ARTICLE Evaluation of BNT162b2 Covid-19 Vaccine in Children Younger than 5 Years of Age Flor M. Muñoz, Lawrence D. Sher, Charu Sabharwal, et al N Engl J Med 2023; 388:621-634DOI: 10.1056/NEJMoa2211031 Abstract BACKGROUND Safe and effective vaccines against coronavirus disease 2019 (Covid-19) are urgently needed in young children. METHODS We conducted a phase 1 dose-finding study and are conducting an ongoing phase 2–3 safety, immunogen...

ORIGINAL ARTICLE Efficacy and Safety of an Ad26.RSV.preF–RSV preF Protein Vaccine in Older Adults Ann R. Falsey, Kristi Williams, Efi Gymnopoulou, et al N Engl J Med 2023; 388:609-620DOI: 10.1056/NEJMoa2207566 Abstract BACKGROUND Respiratory syncytial virus (RSV) can cause serious lower respiratory tract disease in older adults, but no licensed RSV vaccine currently exists. An adenovirus serotype 26 RSV vector encoding a prefusion F (preF) protein (Ad26....

ORIGINAL ARTICLE Respiratory Syncytial Virus Prefusion F Protein Vaccine in Older Adults Alberto Papi, Michael G. Ison, Joanne M. Langley, et al N Engl J Med 2023; 388:595-608DOI: 10.1056/NEJMoa2209604 Abstract BACKGROUND Respiratory syncytial virus (RSV) is an important cause of acute respiratory infection, lower respiratory tract disease, clinical complications, and death in older adults. There is currently no licensed vaccine against RSV infection. ...