ORIGINAL ARTICLE A Bivalent Omicron-Containing Booster Vaccine against Covid-19 Spyros Chalkias, Charles Harper, Keith Vrbicky, et al N Engl J Med September 16, 2022DOI: 10.1056/NEJMoa2208343 Abstract BACKGROUND The safety and immunogenicity of the bivalent omicron-containing mRNA-1273.214 booster vaccine are not known. METHODS In this ongoing, phase 2–3 study, we compared the 50-μg bivalent vaccine mRNA-1273.214 (25 μg each of ancestral Wuhan-Hu-1...

Therapeutic Hyperthermia and Survival in Afebrile Sepsis Patients Fever is an important feature of infection. However, fewer than half of patients with sepsis present with fever at the time of diagnosis. Afebrile sepsis patients have nearly twice the mortality and are at a higher risk of developing secondary infections than patients with fever.  Fever is an adaptive response to infection that may be critical for survival. Studies show that elevated temperat...

Original Investigation  September 27, 2022 Effect of High-Flow Nasal Cannula Oxygen vs Standard Oxygen Therapy on Mortality in Patients With Respiratory Failure Due to COVID-19: The SOHO-COVID Randomized Clinical Trial Jean-Pierre Frat, Jean-Pierre Quenot, Julio Badie, et al JAMA. 2022;328(12):1212-1222. doi:10.1001/jama.2022.15613 Key Points Questions  In patients with respiratory failure due to COVID-19, does the use of high-fl...

CORRESPONDENCE IL-1RA Antibodies in Myocarditis after SARS-CoV-2 Vaccination Lorenz Thurner, Christoph Kessel, Natalie Fadle, et al N Engl J Med September 21, 2022DOI: 10.1056/NEJMc2205667 TO THE EDITOR: Myocarditis associated with messenger RNA (mRNA) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) predominantly affects male adolescents and young male adults (14 to <30 years of age) and typically occurs after receipt of the...

JAMA Clinical Guidelines Synopsis  September 15, 2022 Management of Heart Failure Mark N. Belkin, Adam S. Cifu, Sean Pinney JAMA. Published online September 15, 2022. doi:10.1001/jama.2022.16667 Guideline title 2022 American College of Cardiology (ACC)/American Heart Association AHA)/Heart Failure Society of America (HFSA) Guidelines for the Management of Heart Failure Release date April 1, 2022 Prior versions 2017 ACC/AH...

ICU Management & Practice, Volume 22 - Issue 1, 2022 Doing More Can Be Worse: Ten Common Errors in the ICU Some of the most common interventions in the ICU can be associated with poor results. We present ten situations in which doing less is better for the critically ill patient. Introduction For decades, the focus of patient management in the Intensive Care Unit (ICU) has been to perform a large number of interventions in critically ill patients, man...

Original Investigation  September 20, 2022 Effect of Helmet Noninvasive Ventilation vs Usual Respiratory Support on Mortality Among Patients With Acute Hypoxemic Respiratory Failure Due to COVID-19: The HELMET-COVID Randomized Clinical Trial Yaseen M. Arabi, Sara Aldekhyl, Saad Al Qahtani, et al JAMA. 2022;328(11):1063-1072. doi:10.1001/jama.2022.15599 Key Points Question  What is the effect of noninvasive ventilation delivered b...

Editorials Physician burnout undermines safe healthcare Matthias Weigl BMJ 2022; 378 doi: https://doi.org/10.1136/bmj.o2157 (Published 14 September 2022)Cite this as: BMJ 2022;378:o2157 Urgent action is required to protect patients, physicians, and health systems A substantial proportion of healthcare professionals report symptoms of burnout.12 Research into the negative ramifications of physician burnout is abundant, with key insights already establis...

ICU Management & Practice, Volume 22 - Issue 2, 2022 Sepsis in Critical Care: Effective Antimicrobial Strategies in ICU ICU sepsis is associated with a mortality rate >25%, with nosocomial infection most lethal, and community acquired infection more common. Optimal management requires identification of the site of infection (lung, abdomen and blood stream most commonly), a focus on the likely pathogens based on risk factors for resistance, and provision ...

Research Efficacy and safety of extended duration to perioperative thromboprophylaxis with low molecular weight heparin on disease-free survival after surgical resection of colorectal cancer (PERIOP-01): multicentre, open label, randomised controlled trial Rebecca C Auer, Michael Ott, Paul Karanicolas, et al BMJ 2022; 378 doi: https://doi.org/10.1136/bmj-2022-071375 (Published 13 September 2022)Cite this as: BMJ 2022;378:e071375 Abstract Objective To d...