Research Comparison of short term surgical outcomes of male and female gastrointestinal surgeons in Japan: retrospective cohort study Kae Okoshi, Hideki Endo, Sachiyo Nomura, et al BMJ 2022; 378 doi: https://doi.org/10.1136/bmj-2022-070568 (Published 28 September 2022)Cite this as: BMJ 2022;378:e070568 Abstract Objective To compare short term surgical outcomes between male and female gastrointestinal surgeons in Japan. Design Retrospective coho...

Intravenous Vitamin C in ICU Patients with Sepsis Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis contributes to between a third and a half of deaths in hospitals. It is responsible for nearly 11 million deaths worldwide each year. Treatment of sepsis typically includes antimicrobial therapy, source control, and organ support. It is believed that the antioxidant effects of vitamin C therapy may mitigate tis...

JAMA Clinical Guidelines Synopsis  September 15, 2022 Management of Heart Failure Mark N. Belkin, Adam S. Cifu, Sean Pinney JAMA. 2022;328(13):1346-1347. doi:10.1001/jama.2022.16667 Guideline title 2022 American College of Cardiology (ACC)/American Heart Association AHA)/Heart Failure Society of America (HFSA) Guidelines for the Management of Heart Failure Release date April 1, 2022 Prior versions 2017 ACC/AHA/HFSA Focused Update o...

Research Letter  August 22, 2022 Compassionate Use of Tecovirimat for the Treatment of Monkeypox Infection Angel N. Desai, George R. Thompson III, Sonja M. Neumeister, et al JAMA. 2022;328(13):1348-1350. doi:10.1001/jama.2022.15336 Monkeypox is a zoonotic orthopoxvirus in the same genus as variola (the causative agent of smallpox).1 A recent global outbreak has led to more than 39 000 cases reported as of August 18, 2022.2 Monkeypox is typica...

Mental Health Morbidity Among ICU Survivors and Caregivers There is significant evidence that patients who survive critical illness experience morbidity after discharge from the ICU. This is commonly referred to as the post-intensive care syndrome (PICS). In addition to a negative impact on the physical health of ICU survivors, PICS also includes mental health morbidity.  Studies have shown that mechanically ventilated ICU survivors have a higher incidence ...

Original Investigation  October 4, 2022 Effect of a Postoperative Multimodal Opioid-Sparing Protocol vs Standard Opioid Prescribing on Postoperative Opioid Consumption After Knee or Shoulder Arthroscopy: A Randomized Clinical Trial The NO PAin Investigators JAMA. 2022;328(13):1326-1335. doi:10.1001/jama.2022.16844 Key Points Question  Does a multimodal opioid-sparing postoperative pain protocol reduce postoperative opioid consump...

Original Investigation  October 4, 2022 Effect of Cefepime/Enmetazobactam vs Piperacillin/Tazobactam on Clinical Cure and Microbiological Eradication in Patients With Complicated Urinary Tract Infection or Acute Pyelonephritis: A Randomized Clinical Trial Keith S. Kaye, Adam Belley, Philip Barth, et al JAMA. 2022;328(13):1304-1314. doi:10.1001/jama.2022.17034 Key Points Question  How does the efficacy of cefepime/enmetazobactam c...

ORIGINAL RESEARCH|ARTICLES IN PRESS Recall of awareness during paralysis among emergency department patients undergoing tracheal intubation Brian E. Driver, Matthew E. Prekker, Emily Wagner, et al Chest Published:September 08, 2022 DOI:https://doi.org/10.1016/j.chest.2022.08.2232 ABSTRACT Background Critically ill patients sometimes remember periods of neuromuscular blockade. Research Question What is the prevalence of recalled awareness during ...

Enteral Nutrition Practices in ICU Patients With Circulatory Shock Approximately one-third of patients admitted to the ICU are in circulatory shock, which increases the risk of mortality. Death from circulatory shock is preceded by multiple organ dysfunction syndrome with a high mortality rate of over 80%. Loss of gut epithelial barrier function contributes to gut-derived proinflammatory immune responses that contribute to multiple organ dysfunction.  Studi...

ARTICLES|ONLINE FIRST Artificial intelligence-guided screening for atrial fibrillation using electrocardiogram during sinus rhythm: a prospective non-randomised interventional trial Peter A Noseworthy, Zachi I Attia, Emma M Behnken, et al  Lancet Published:September 27, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)01637-3 Summary Background Previous atrial fibrillation screening trials have highlighted the need for more targeted approaches. We did a...