Research Cerebral regional tissue Oxygen Saturation to Guide Oxygen Delivery in preterm neonates during immediate transition after birth (COSGOD III): multicentre randomised phase 3 clinical trial Gerhard Pichler, Katharina Goeral, Marlene Hammerl, et al BMJ 2023; 380 doi: https://doi.org/10.1136/bmj-2022-072313 (Published 24 January 2023)Cite this as: BMJ 2023;380:e072313 Abstract Objective To investigate whether monitoring of cerebral tissue oxygen s...

Feature Covid Unanswered Questions How are covid-19 symptoms changing? Mun-Keat Looi BMJ 2023; 380 doi: https://doi.org/10.1136/bmj.p3 (Published 18 January 2023)Cite this as: BMJ 2023;380:p3 With new variants and a changing landscape of vaccination and immunity, what do the symptoms of covid-19—and our understanding of them—now look like? Mun-Keat Looireports How have covid symptoms changed since the start of the pandemic? In the short space o...

Multisystem Inflammatory Syndrome in Adults: Case Finding Through Systematic Review of Electronic Medical Records  Michael Melgar,  Julia Haston,  Jennifer DeCuir,  et al Clinical Infectious Diseases, Volume 75, Issue 11, 1 December 2022, Pages 1903–1911, https://doi.org/10.1093/cid/ciac303 Abstract Background Multisystem inflammatory syndrome in adults (MIS-A) is a severe condition temporally associated with severe acute respiratory syndrome coronavir...

Editorial  January 17, 2023 TRANSFORM-HF—Can We Close the Loop on Diuretics in Heart Failure? Michelle M. Kittleson JAMA. 2023;329(3):211-213. doi:10.1001/jama.2022.21692 Fluid overload is the cardinal manifestation of heart failure, and prior to the 20th century, treatment options were limited to purgatives, bloodletting, leeching, or lancing. It was not until 1920 that the concept of a diuretic was first appreciated, when physicians observe...

ORIGINAL ARTICLE Efanesoctocog Alfa Prophylaxis for Patients with Severe Hemophilia A Annette von Drygalski, Pratima Chowdary, Roshni Kulkarni, et al N Engl J Med 2023; 388:310-318DOI: 10.1056/NEJMoa2209226 Abstract BACKGROUND Efanesoctocog alfa provides high sustained factor VIII activity by overcoming the von Willebrand factor–imposed half-life ceiling. The efficacy, safety, and pharmacokinetics of efanesoctocog alfa for prophylaxis and treatment of bl...

COMMENT|ONLINE FIRST COVID-19 infection, reinfection, and the transition to endemicity Cheryl Cohen, Juliet Pulliam Lancet Published: February 16, 2023 DOI:https://doi.org/10.1016/S0140-6736(22)02634-4 Understanding the protection conferred by previous infection against repeat infection, illness, and severe disease is key to projecting the future epidemiology of COVID-19 and to guiding vaccine policy decisions. In The Lancet, The COVID-19 Forecasting Team1 ...

ORIGINAL ARTICLE Cystatin C–Based Equation to Estimate GFR without the Inclusion of Race and Sex Hans Pottel, Jonas Björk, Andrew D. Rule, et al N Engl J Med 2023; 388:333-343DOI: 10.1056/NEJMoa2203769 Abstract BACKGROUND The accuracy of estimation of kidney function with the use of routine metabolic tests, such as measurement of the serum creatinine level, has been controversial. The European Kidney Function Consortium (EKFC) developed a creatinine-base...

ARTICLES|ONLINE FIRST Past SARS-CoV-2 infection protection against re-infection: a systematic review and meta-analysis COVID-19 Forecasting Team Lancet Published: February 16, 2023 DOI:https://doi.org/10.1016/S0140-6736(22)02465-5 Summary Background Understanding the level and characteristics of protection from past SARS-CoV-2 infection against subsequent re-infection, symptomatic COVID-19 disease, and severe disease is essential for predicting future...

Medical News in Brief  February 8, 2023 Updated COVID-19 Guidance for People Who Are Immunocompromised Emily Harris JAMA. Published online February 8, 2023. doi:10.1001/jama.2023.1176 In late January, the US Food and Drug Administration announced that Evusheld (the combined monoclonal antibodies tixagevimab and cilgavimab) is not currently authorized for emergency use because it’s likely ineffective against more than 90% o...

REVIEW| VOLUME 10, ISSUE 12, P1178-1188, DECEMBER 01, 2022 Respiratory system mechanics, gas exchange, and outcomes in mechanically ventilated patients with COVID-19-related acute respiratory distress syndrome: a systematic review and meta-analysis Mallikarjuna Ponnapa Reddy, Ashwin Subramaniam, Clara ChuaRyan Ruiyang Ling et al. Lancet Respir Med 2022; 10: 1178-1188 Published:November 03, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00393-9 ...