Editorial  October 26, 2022 Early Oxygen Supplementation After Resuscitation From Cardiac Arrest Jonathan Elmer, Francis X. Guyette JAMA. Published online October 26, 2022. doi:10.1001/jama.2022.18620 Supplemental oxygen administration was first noted to correct signs and symptoms of hypoxic respiratory failure more than a century ago.1,2 Since that time, oxygen has become one of the most widely administered therapeutic interventions in ...

Response to PEEP in COVID-19 ARDS With & Without ECMO There have been conflicting results concerning lung recruitability of COVID-19 acute respiratory distress syndrome (ARDS) and the use of techniques derived from changes in respiratory mechanics and/or gas exchange in response to positive end-expiratory pressure (PEEP) increase. Various factors may explain the heterogeneity of reports regarding recruitability of COVID-19 ARDS. These include time from ARDS ons...

Original Investigation  October 26, 2022 Effect of Lower vs Higher Oxygen Saturation Targets on Survival to Hospital Discharge Among Patients Resuscitated After Out-of-Hospital Cardiac Arrest: The EXACT Randomized Clinical Trial Stephen A. Bernard, Janet E. Bray, Karen Smith, et al JAMA. Published online October 26, 2022. doi:10.1001/jama.2022.17701 Key Points Question  Among patients with return of spontaneous circulation after ...

Original Investigation  Caring for the Critically Ill Patient October 26, 2022 Association of Extracorporeal Membrane Oxygenation With New Mental Health Diagnoses in Adult Survivors of Critical Illness Shannon M. Fernando, Mary Scott, Robert Talarico, et al JAMA. Published online October 26, 2022. doi:10.1001/jama.2022.17714 Key Points Question  Is the use of extracorporeal membrane oxygenation (ECMO) associated with postdisch...

Noninvasive Respiratory Support in Intensive Care Most forms of ventilatory support in intensive care before the 1950s were noninvasive without direct access to the lower airways, using face mask for positive pressure or generating negative pressure around the chest. Ventilators stimulating negative pressure were designed in the late 19th century. The first application of positive end-expiratory pressure (PEEP) was first described in the 1930s.  After the i...

Trends in Antimicrobial Prescribing During Hospitalisation for Sepsis There have been concerns that the emphasis on rapid administration of antimicrobials for sepsis may result in an increase in the overall use of antimicrobials, even in patients without sepsis. In a study of 1,559,523 patients hospitalised at 152 hospitals in two health care delivery systems, researchers aimed to determine whether shortening the time to treatment for sepsis was associated ...

ARTICLES| VOLUME 10, ISSUE 10, P972-984, OCTOBER 01, 2022 Tixagevimab–cilgavimab for treatment of patients hospitalised with COVID-19: a randomised, double-blind, phase 3 trial ACTIV-3–Therapeutics for Inpatients with COVID-19 (TICO) Study Group Lancet Respir Med 2022; 10: 972-984 Summary Background Tixagevimab–cilgavimab is a neutralising monoclonal antibody combination hypothesised to improve outcomes for patients hospitalised with COVID...

ARTICLES| VOLUME 10, ISSUE 10, P985-996, OCTOBER 01, 2022 Efficacy and safety of intramuscular administration of tixagevimab–cilgavimab for early outpatient treatment of COVID-19 (TACKLE): a phase 3, randomised, double-blind, placebo-controlled trial Hugh Montgomery, F D Richard Hobbs, Francisco Padilla, et al Lancet Respir Med 2022; 10: 985-996 Summary Background Early intramuscular administration of SARS-CoV-2-neutralising monoclonal ant...

ORIGINAL ARTICLE Haloperidol for the Treatment of Delirium in ICU Patients Nina C. Andersen-Ranberg, Lone M. Poulsen, Anders Perner, et al N Engl J Med October 26, 2022DOI: 10.1056/NEJMoa2211868 Abstract BACKGROUND Haloperidol is frequently used to treat delirium in patients in the intensive care unit (ICU), but evidence of its effect is limited. METHODS In this multicenter, blinded, placebo-controlled trial, we randomly assigned adult patients wit...

Serial Measurement of Pancreatic Stone Protein for Detection of Sepsis Sepsis continues to be a challenging health problem associated with high morbidity and mortality. Approximately 48.9 million cases of sepsis were recorded worldwide in 2017, with 11 million related deaths. Sepsis guidelines emphasise the early recognition and aggressive management of this condition with early antibiotic treatment and support. If not treated early, sepsis can evolve into life-thr...