Feature Christmas 2025: Black Mirror Parallel pressures: the common roots of doctor bullshit and large language model hallucinations Roberto A Correa Soto, Liam G McCoy, Camilo Perdomo-Luna, et al BMJ 2025; 391 doi: https://doi.org/10.1136/bmj.r2570 (Published 12 December 2025)Cite this as: BMJ 2025;391:r2570 Roberto Correa Sotoand colleagues argue that the drive that leads doctors to make unfounded statements are mirrored in the forces that cause LL...

Articles A preventive care strategy to reduce moderate or severe acute kidney injury after major surgery (BigpAK-2); a multinational, randomised clinical trial Alexander Zarboci, Marlies Ostermann, Lui Forni, et al Lancet 2025; 406: 2787-2791 https://doi.org/10.1016/S0140-6736(25)01717-9 Summary Background Acute kidney injury (AKI) is a common and important complication of major surgery, yet recommended preventive care is rarely administered. We used ...

Research Christmas 2025:  Changes in diversity language in National Institutes of Health grant awards: observational study Neil Mehta, Anupam B Jena, Joseph P Newhouse BMJ 2025; 391 doi: https://doi.org/10.1136/bmj-2025-087222 (Published 11 December 2025)Cite this as: BMJ 2025;391:e087222 Abstract Objective To assess changes in the prevalence of diversity language in National Institutes of Health (NIH) grants in 2024-25. Design Retros...

Airway Management in Patients With Acute Traumatic Brain Injury: An Evidence-Based Approach In ICU Thu, 24 Jul 2025 ICU Management & Practice, Volume 25 - Issue 3, 2025 This review highlights airway management in traumatic brain injury, focusing on strategies to prevent secondary brain injury. Key interventions include advanced preoxygenation, haemodynamic stabilisation, cautious sedation, selective use of prehospital intubation or supraglottic devi...

Research Christmas 2025: Words and meanings How recent is recent? Retrospective analysis of suspiciously timeless citations Alejandro Díez-Vidal, Jose R Arribas BMJ 2025; 391 doi: https://doi.org/10.1136/bmj-2025-086941 (Published 11 December 2025)Cite this as: BMJ 2025;391:e086941 Abstract Objective To quantify the time lag between biomedical articles and the studies they describe as “recent,” a term widely used to imply timeliness despite rarely...

ORIGINAL ARTICLE Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults Jonathan D. Casey, Kevin P. Seitz, Brian E. Driver, et al N Engl J Med Published December 9, 2025 DOI: 10.1056/NEJMoa2511420 Abstract BACKGROUND For critically ill adults undergoing tracheal intubation, observational studies suggest that the use of etomidate to induce anesthesia may increase the risk of death. Whether the use of ketamine rather than etomidate decre...

Vasopressin in Septic Shock: New Insights on Timely Addition to Norepinephrine In ICU Thu, 24 Jul 2025 ICU Management & Practice, Volume 25 - Issue 3, 2025 Early vasopressin initiation in septic shock may improve outcomes beyond the current practice of waiting for higher norepinephrine doses. Recent studies suggest starting AVP earlier can reduce shock duration and hospital mortality. Despite AVP often being started late, a proactive, protocol-d...

Original Investigation  Infectious Diseases Syndromic Analysis of Sepsis Cohorts Using Large Language Models Theodore R. Pak, Sanjat Kanjilal, Caroline S. McKenna, et al JAMA Netw Open 2025;8;(10):e2539267. doi:10.1001/jamanetworkopen.2025.39267 Key Points Question  Can large language models (LLMs) accurately extract presenting signs and symptoms from clinical notes to identify associations between sympto...

Editorial Postpartum haemorrhage: aligning for renewed action The Lancet Global Health Lancet Global Health 2025; 13: e1781 https://doi.org/10.1016/S2214-109X(25)00417-6 October 5 marked the first World Postpartum Haemorrhage Day. Postpartum haemorrhage (PPH) is the leading cause of maternal mortality globally, despite being largely preventable. Addressing it will be key to achieving the currently unreachable Sustainable Development Goal of reduci...

Articles Recommendations for lung ventilation and perfusion assessment with chest electrical impedance tomography in critically ill adult patients: an international evidence-based and expert Delphi consensus study Huaiwu He, Zhanqi Zhao, Tobias Becher, et al eClinicalMedicine 2025; 89: 103575 https://doi.org/10.1016/j.eclinm.2025.103575 Summary Background Electrical impedance tomography (EIT) is a non-invasive, radiation-free imaging technique that al...