ORIGINAL ARTICLE Racial and Ethnic Differences in Bystander CPR for Witnessed Cardiac Arrest R. Angel Garcia, John A. Spertus, Saket Girotra, et al N Engl J Med 2022; 387:1569-1578DOI: 10.1056/NEJMoa2200798 Abstract BACKGROUND Differences in the incidence of cardiopulmonary resuscitation (CPR) provided by bystanders contribute to survival disparities among persons with out-of-hospital cardiac arrest. It is critical to understand whether the incidence of ...

ORIGINAL RESEARCH|ARTICLES IN PRESS High-Dose Intravenous Hydroxocobalamin (Vitamin B12) in Septic Shock: A Double-Blind, Allocation-Concealed, Placebo-Controlled Single-Center Pilot Randomized Controlled Trial (The IV-HOCSS Trial) Jayshil J. Patel, Rodney Willoughby, Jennifer Peterson, et al Chest Published:September 26, 2022 DOI:https://doi.org/10.1016/j.chest.2022.09.021 Abstract Background Elevated hydrogen sulfide (H2S) contributes to vasodilatat...

DIFFUSE LUNG DISEASE: ORIGINAL RESEARCH| VOLUME 162, ISSUE 4, P815-823, OCTOBER 01, 2022 Predicting Usual Interstitial Pneumonia Histopathology From Chest CT Imaging With Deep Learning Alex Bratt, James M. Williams, Grace Liu, MD  Chest 2022; 162: 815-823 Published: April 08, 2022 DOI:https://doi.org/10.1016/j.chest.2022.03.044 Background Idiopathic pulmonary fibrosis (IPF) is a progressive, often fatal form of interstitial lung disease (I...

ICU Management & Practice, Volume 22 - Issue 1, 2022 Processes to Reduce Medication Errors in the ICU Medication errors are common in the complex environment of the ICU. This article provides an overview of the prevalence and impact of these errors and the processes that could help reduce their incidence. Introduction Medicines are the most widely used intervention in the critical care environment, and errors in medication use are a well-established c...

Original Investigation  October 10, 2022 Estimated Global Proportions of Individuals With Persistent Fatigue, Cognitive, and Respiratory Symptom Clusters Following Symptomatic COVID-19 in 2020 and 2021 Global Burden of Disease Long COVID Collaborators JAMA. Published online October 10, 2022. doi:10.1001/jama.2022.18931 Key Points Question  Among individuals who had symptomatic SARS-CoV-2 infection in 2020 and 2021, what prop...

Research Letter  October 19, 2022 Extended Follow-up of Microbiome Therapeutic SER-109 Through 24 Weeks for Recurrent Clostridioides difficile Infection in a Randomized Clinical Trial Stuart H. Cohen, Thomas J. Louie, Matthew Sims, et al JAMA. Published online October 19, 2022. doi:10.1001/jama.2022.16476 Antibiotics are necessary but often insufficient to treat recurrent Clostridioides difficile infection (rCDI) due to pe...

Original Investigation  October 22, 2022 Viral Shedding 1 Year Following First-Episode Genital HSV-1 Infection Christine Johnston, Amalia Magaret, Hyunju Son, et al JAMA. Published online October 22, 2022. doi:10.1001/jama.2022.19061 Key Points Question  What are the rates of viral shedding after first-episode genital herpes simplex virus type 1 (HSV-1) infection? Findings  In this prospective cohort study, 82 partic...

#LIVES2022: High-Flow Nasal Cannula Oxygen vs Standard Oxygen Therapy - SOHO-COVID At the Presidents' Ground Breaking Research Release session at ESICM LIVES 2022 in Paris, Jean-Pierre Frat (Poitiers, France) presented the findings from the Standard Oxygen Versus High Flow Cannula Oxygen Therapy in Patients With Acute Hypoxemic Respiratory Failure (SOHO-COVID) trial.  COVID-19 has resulted in over six million deaths worldwide due to acute hypoxaemic respira...

Original Investigation  October 21, 2022 Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19: A Randomized Clinical Trial Susanna Naggie, David R. Boulware, Christopher J. Lindsell, et al JAMA. Published online October 21, 2022. doi:10.1001/jama.2022.18590 Key Points Question  Does ivermectin, 400 μg/kg, daily for 3 days, compared with placebo, shorten symptom duration among...

#LIVES2022: Extubation Strategies in Neuro-Intensive Care Unit Patients Findings from the Extubation strategies and in Neuro-Intensive care unit patients and associations with Outcomes (ENIO) study were presented this week at ESICM LIVES 2022.  Invasive mechanical ventilation is a primary intervention in critically ill patients. Timely weaning reduces the risk of hospital-acquired pneumonia, chronic illness and cost of care. In particular, neurocritical car...