ICU Management & Practice, Volume 22 - Issue 4, 2022 Rapid Diagnostics and Antimicrobial Resistance in the ICU The need to address the problem of antimicrobial resistance, the importance of faster diagnosis of bacterial infections and an overview of rapid diagnostic testing. Antimicrobial resistance (AMR) is rapidly increasing on a global scale. The discovery of penicillin revolutionised the field of medicine, providing safe harbour from the most pressin...

ORIGINAL ARTICLE Azithromycin to Prevent Sepsis or Death in Women Planning a Vaginal Birth Alan T.N. Tita, Waldemar A. Carlo, Elizabeth M. McClure, et al N Engl J Med February 9, 2023DOI: 10.1056/NEJMoa2212111 Abstract BACKGROUND The use of azithromycin reduces maternal infection in women during planned cesarean delivery, but its effect on those with planned vaginal delivery is unknown. Data are needed on whether an intrapartum oral dose of azithrom...

Original Investigation  February 9, 2023 Effect of Argatroban Plus Intravenous Alteplase vs Intravenous Alteplase Alone on Neurologic Function in Patients With Acute Ischemic Stroke: The ARAIS Randomized Clinical Trial Hui-Sheng Chen, Yu Cui, Zhong-He Zhou, et al JAMA. Published online February 9, 2023. doi:10.1001/jama.2023.0550 Key Points Question  Does argatroban improve neurologic function in patients with acute ischemic stro...

ARTICLES| VOLUME 401, ISSUE 10375, P447-457, FEBRUARY 11, 2023 Pregnancy outcomes and vaccine effectiveness during the period of omicron as the variant of concern, INTERCOVID-2022: a multinational, observational study Jose Villar, Constanza P Soto Conti, Robert B Gunier, et al. Lancet 2023; 401: 447-457 Published:January 17, 2023 DOI:https://doi.org/10.1016/S0140-6736(22)02467-9 Summary Background In 2021, we showed an increased risk as...

ICU Management & Practice, Volume 22 - Issue 4, 2022 Does Antimicrobial Resistance Affect Clinical Outcomes in the ICU? An overview of antimicrobial resistance and its impact on clinical outcomes in the ICU.  Antimicrobial resistance (AMR) has been defined as a major threat to healthcare and to humanity by the World Health Organization (WHO 2015). The level of evidence for the association between AMR and hospital deaths, hospital length of stay and ...

ARTICLES|ONLINE FIRST Characterisation of SARS-CoV-2 variants in Beijing during 2022: an epidemiological and phylogenetic analysis Yang Pan, Liang Wang, Zhaomin Feng, et al. Lancet Published:February 08, 2023 DOI:https://doi.org/10.1016/S0140-6736(23)00129-0 Summary Background Due to the national dynamic zero-COVID strategy in China, there were no persistent local transmissions of SARS-CoV-2 in Beijing before December, 2022. However, imported cases ha...

Editorial  February 7, 2023 Manufacturer Spending on Direct-to-Consumer Advertising for Pharmaceutical Products Amanda Starc JAMA. 2023;329(5):371-373. doi:10.1001/jama.2022.24078 The tension between physicians and drugmakers, especially over marketing, dates to the era of patent medicines.1 Since 1997, pharmaceutical manufacturers have advertised directly to US consumers, amplifying controversy over the role of drug marketing in clinica...

ORIGINAL ARTICLE Lobar or Sublobar Resection for Peripheral Stage IA Non–Small-Cell Lung Cancer Nasser Altorki, Xiaofei Wang, David Kozono, et al N Engl J Med 2023; 388:489-498DOI: 10.1056/NEJMoa2212083 Abstract BACKGROUND The increased detection of small-sized peripheral non–small-cell lung cancer (NSCLC) has renewed interest in sublobar resection in lieu of lobectomy. METHODS We conducted a multicenter, noninferiority, phase 3 trial in which...

Original Investigation  January 26, 2023 Household Transmission of Influenza A Viruses in 2021-2022 Melissa A. Rolfes, H. Keipp Talbot, Huong Q. McLean, et al JAMA. Published online January 26, 2023. doi:10.1001/jama.2023.0064 Key Points Question  What is the risk of influenza A(H3N2) virus infection among household contacts of patients diagnosed with influenza during the 2021-2022 season compared with influenza seasons before th...

ICU Management & Practice, Volume 22 - Issue 4, 2022 Multidrug-Resistant Gram-Negative Bacteria in the ICU Severe infections by antibiotic resistant gram-negative bacteria are frequent in ICU patients. They are associated with high morbidity and mortality. Introduction Bacterial infections in patients hospitalised in the Intensive Care Unit (ICU) are frequent, and they elicit an increase in morbidity and mortality. The emerging development of antibiot...