Research Clinical and cost effectiveness of single stage compared with two stage revision for hip prosthetic joint infection (INFORM): pragmatic, parallel group, open label, randomised controlled trial Ashley W Blom, Erik Lenguerrand, Simon Strange, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-071281 (Published 31 October 2022)Cite this as: BMJ 2022;379:e071281 Abstract Objectives To determine whether patient reported outcomes improve afte...

Original Investigation  November 3, 2022 Association Between Preoperative Hemodialysis Timing and Postoperative Mortality in Patients With End-stage Kidney Disease Vikram Fielding-Singh, Matthew W. Vanneman, Tristan Grogan, et al JAMA. 2022;328(18):1837-1848. doi:10.1001/jama.2022.19626 Key Points Question  Is there an association between the timing of preoperative hemodialysis relative to surgery and postoperative mortality in patients wi...

Research Novel antihyperglycaemic drugs and prevention of chronic obstructive pulmonary disease exacerbations among patients with type 2 diabetes: population based cohort study Richeek Pradhan, Sally Lu, Hui Yin, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-071380 (Published 01 November 2022)Cite this as: BMJ 2022;379:e071380 Abstract Objective To determine whether the use of glucagon-like peptide 1 (GLP-1) receptor agonists, dipeptidyl pe...

Neurologic Manifestations of COVID-19 Approximately 10-15% of patients with COVID-19 require ICU treatment. Respiratory failure and multi-organ dysfunction are the most common indications for ICU admission. However, nearly 1/3 of COVID-19 patients also present with neurologic manifestations. Neurologic manifestations are believed to predict mortality and functional outcome. While there have been reports of neurologic manifestations in patients with COVID-19,&nbs...

ARTICLES|ONLINE FIRST Antibiotic review kit for hospitals (ARK-Hospital): a stepped-wedge cluster-randomised controlled trial Martin J Llewelyn, Eric P Budgell, Magda Laskawiec-Szkonter, et al Lancet Infect Dis Published:October 04, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00508-4 Summary Background Strategies to reduce antibiotic overuse in hospitals depend on prescribers taking decisions to stop unnecessary antibiotic use. There is scarce evid...

Research Effect of oral antimicrobial prophylaxis on surgical site infection after elective colorectal surgery: multicentre, randomised, double blind, placebo controlled trial Emmanuel Futier, Samir Jaber, Matthias Garot, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-071476 (Published 03 November 2022)Cite this as: BMJ 2022;379:e071476 Abstract Objective To investigate whether oral antimicrobial prophylaxis as an adjunct to intravenous anti...

Impact of Health Information Technology in Acute Care Settings Critically ill patients admitted to inpatient facilities are often at risk of acute physiologic deterioration. This deterioration can lead to prolonged hospitalisation, admission to the ICU, and cardiorespiratory arrest. Often, a patient's worsening condition remains undetected for hours before the escalation of care. Strategies have been used to recognise deterioration early, ranging from ale...

ARTICLES|ONLINE FIRST Routine sterile glove and instrument change at the time of abdominal wound closure to prevent surgical site infection (ChEETAh): a pragmatic, cluster-randomised trial in seven low-income and middle-income countries NIHR Global Research Health Unit on Global Surgery Lancet Published:October 31, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)01884-0 Summary Background Surgical site infection (SSI) remains the most common complicati...

ARTICLES|ONLINE FIRST Personalised cooler dialysate for patients receiving maintenance haemodialysis (MyTEMP): a pragmatic, cluster-randomised trial The MyTEMP writing committee Lancet Published: November 04, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)01805-0 Summary Background Haemodialysis centres have conventionally provided maintenance haemodialysis using a standard dialysate temperature (eg, 36·5°C) for all patients. Many centres now use cool...

ARTICLES| VOLUME 400, ISSUE 10363, P1607-1617, NOVEMBER 05, 2022 Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries NIHR Global Health Unit on Global Surgery, COVIDSurg Collaborative Lancet 2022; 400: 1607-1617  Summary Background The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic...