Pancreatic Stone Protein Testing Reduces Expenditure in Sepsis Sepsis is a life-threatening organ dysfunction and a cause of significant morbidity and mortality. In addition, the high number of sepsis cases is a significant economic burden for healthcare systems. Statistics show that sepsis was the most expensive condition treated in the U.S. in 2013, costing nearly $24 billion. An analysis of Medicare claims in 2020 found a 40% increase in sepsis-related hospital ...

ARTICLES| VOLUME 10, ISSUE 11, P1061-1073, NOVEMBER 01, 2022 Onset and window of SARS-CoV-2 infectiousness and temporal correlation with symptom onset: a prospective, longitudinal, community cohort study Seran Hakki, Jie Zhou, Jakob Jonnerby, et al Lancet Respir Med 2022; 10: 1061-1073 Published:August 18, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00226-0 Summary Background Knowledge of the window of SARS-CoV-2 infectiousness is cr...

ARTICLES| VOLUME 10, ISSUE 11, P1038-1048, NOVEMBER 01, 2022 Incidence of death or disability at 6 months after extracorporeal membrane oxygenation in Australia: a prospective, multicentre, registry-embedded cohort study Carol L Hodgson, Alisa M Higgins, Michael J Bailey, et al Lancet Respir Med Published:September 26, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00248-X Summary Background Extracorporeal membrane oxygenation (ECMO) is...

ARTICLES| VOLUME 22, ISSUE 11, P1626-1647, NOVEMBER 01, 2022 Age–sex differences in the global burden of lower respiratory infections and risk factors, 1990–2019: results from the Global Burden of Disease Study 2019 GBD 2019 LRI Collaborators Lancet Infect Dis 2022; 11: 1626-1647 Published:August 11, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00510-2 Summary Background The global burden of lower respiratory infections (LRIs) and cor...

ICU Management & Practice, Volume 21 - Issue 3, 2021 Oxygen Therapy in COVID-19 Patients: The Role of HFNC and CPAP Oxygen therapy and mechanical ventilation in patients with COVID-19 and steps to choose the right therapeutic strategy for each patient. Introduction Severe acute respiratory syndrome coronavirus CoV-2 is the highly contagious viral agent responsible for the ongoing COVID-19 pandemic. COVID-19 is the name of the syndrome caused by SARS-C...

ARTICLES| VOLUME 10, ISSUE 11, P1074-1085, NOVEMBER 01, 2022 Daily use of lateral flow devices by contacts of confirmed COVID-19 cases to enable exemption from isolation compared with standard self-isolation to reduce onward transmission of SARS-CoV-2 in England: a randomised, controlled, non-inferiority trial Nicola K Love, Derren R Ready, Charlie Turner, et al. Lancet Respir Med 2022; 10: 1074-1085 DOI:https://doi.org/10.1016/S2213-2600(22)002...

ORIGINAL ARTICLE Liquefied Petroleum Gas or Biomass for Cooking and Effects on Birth Weight Thomas F. Clasen, Howard H. Chang, Lisa M. Thompson, et al N Engl J Med 2022; 387:1735-1746DOI: 10.1056/NEJMoa2206734 Abstract BACKGROUND Exposure during pregnancy to household air pollution caused by the burning of solid biomass fuel is associated with adverse health outcomes, including low birth weight. Whether the replacement of a biomass cookstove with a lique...

Sleep Assessment in Critically Ill Adults Sleep in adult patients in the ICU is severely disturbed and typically short, light and fragmented. In addition, interventions in the ICU such as sedation, ventilation and illness can alter sleep characteristics. Some of the most common causes of sleep disruption include environmental factors such as noise and light; physiologic factors, such as pain, immobility, discomfort and coughing; care-related factors, such as nursin...

ORIGINAL ARTICLE Lifting Universal Masking in Schools — Covid-19 Incidence among Students and Staff Tori L. Cowger, Eleanor J. Murray, Jaylen Clarke, et al N Engl J Med 2022; 387:1935-1946DOI: 10.1056/NEJMoa2211029 Abstract BACKGROUND In February 2022, Massachusetts rescinded a statewide universal masking policy in public schools, and many Massachusetts school districts lifted masking requirements during the subsequent weeks. In the greater Boston a...

ORIGINAL ARTICLE Progression of Atrial Fibrillation after Cryoablation or Drug Therapy Jason G. Andrade, Marc W. Deyell, Laurent Macle, et al N Engl J Med November 7, 2022DOI: 10.1056/NEJMoa2212540 Abstract BACKGROUND Atrial fibrillation is a chronic, progressive disorder, and persistent forms of atrial fibrillation are associated with increased risks of thromboembolism and heart failure. Catheter ablation as initial therapy may modify the pathogenic mec...