Prehospital Lyophilised Plasma Transfusion for Trauma-Induced Coagulopathy Trauma-induced coagulopathy affects approximately 20 to 50% of patients with severe trauma. Its occurrence increases transfusion requirements, multi-visceral failure, and mortality. Blood transfusion is the primary therapy for trauma-induced coagulopathy. However, optimal modalities for plasma transfusion in a prehospital setting remain undefined. Findings from the COMBAT (Control of...

Feature Christmas 2022: The Scientist On the 12th Day of Christmas, a Statistician Sent to Me . . . Richard D Riley, Tim J Cole, Jon Deeks, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072883 (Published 20 December 2022)Cite this as: BMJ 2022;379:e072883 The BMJ’s statistical editors relish a quiet Christmas, so make their wish come true and pay attention to the list of common statistical faux pas presented here by Riley and colleagues ...

Research Christmas 2022: R-E-S-P-E-C-T Direct Uptake of Nutrition and Caffeine Study (DUNCS): biscuit based comparative study Ceri Jones, John Francis BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072839 (Published 19 December 2022)Cite this as: BMJ 2022;379:e072839 Abstract Objectives To identify the time required to achieve optimal palatability of a cup of tea without risk of harm (oral scalding) using the resources available in a standard...

ARTICLES| VOLUME 10, ISSUE 12, P1119-1128, DECEMBER 01, 2022 Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial Holly R Keir, Merete B Long, Hani Abo-Leyah, et al. Lancet Respir Med 2022; 10: 1119-1128 Published:September 05, 2022 DOI: https://doi.org/10.1016/S2213-2600(22)00261-2 Summary Background Neutrophil serine proteases are in...

Venous Thromboembolism in Sepsis Septic patients are often affected by coagulation disorders. Hence, they are at a high risk of thrombotic complications, ranging from widespread microvascular involvement, such as disseminated intravascular coagulation, to venous thromboembolism, arising as deep vein thrombosis or pulmonary embolism. Over the years, knowledge about the interconnected and reciprocal influence of immune and coagulation systems has emerged. This phe...

Research Christmas 2022: Physical A Christmas themed physical activity intervention to increase participation in physical activity during Advent: pilot randomised controlled trial Gregory J H Biddle, James P Sanders, Kajal Gokal, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072807 (Published 19 December 2022)Cite this as: BMJ 2022;379:e072807 Abstract Objectives To examine the recruitment, retention, and preliminary effects of a Chris...

Research Christmas 2022: The Scientist Evaluation of editors’ abilities to predict the citation potential of research manuscripts submitted to The BMJ: a cohort study Sara Schroter, Wim E J Weber, Elizabeth Loder, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-073880 (Published 14 December 2022)Cite this as: BMJ 2022;379:e073880 Abstract Objective To evaluate the ability of The BMJ editors to predict the number of times s...

ARTICLES|ONLINE FIRST Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019 GBD 2019 Antimicrobial Resistance Collaborators Lancet Published: November 21, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)02185-7 Summary Background Reducing the burden of death due to infection is an urgent global public health priority. Previous studies have estimated the number of deaths associ...

Capnodynamic Monitoring to Assess PEEP in COVID-19 Optimal positive end-expiratory pressure (PEEP) level during mechanical ventilation for COVID-19 pneumonia remains debated. A third of experts in a recent consensus statement supported a low-level PEEP for COVID-19-related acute respiratory failure (C-ARDS), with half of the panel remaining neutral without agreement on PEEP titration. However, the Surviving Sepsis Campaign guideline recommends using high level of P...

Research Angiotensin receptor blockers for the treatment of covid-19: pragmatic, adaptive, multicentre, phase 3, randomised controlled trial Meg J Jardine, Sradha S Kotwal, Abhinav Bassi, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072175 (Published 16 November 2022)Cite this as: BMJ 2022;379:e072175 Abstract Objective To determine whether disrupting the renin angiotensin system with angiotensin receptor blockers will improve clinical out...