Prevalence and Mechanisms of Mucus Accumulation in COVID-19 Lung Disease Takafumi Kato,  Takanori Asakura,  Caitlin E. Edwards, et al Am J Respir Crit Care Med 2022 Dec 1;206(11):1336-1352. doi: 10.1164/rccm.202111-2606OC Abstract Rationale: The incidence and sites of mucus accumulation and molecular regulation of mucin gene expression in coronavirus (COVID-19) lung disease have not been reported. Objectives: To characterize the incidence of mu...

Research Christmas 2022: Physical Quantifying the benefits of inefficient walking: Monty Python inspired laboratory based experimental study Glenn A Gaesser, David C Poole, Siddhartha S Angadi BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072833 (Published 21 December 2022)Cite this as: BMJ 2022;379:e072833 Abstract Objective To compare the rate of energy expenditure of low efficiency walking with high efficiency walking. Design Labo...

Sex Differences in Mortality of ICU Patients According to Diagnosis-related Sex Balance Lucy J. Modra,  Alisa M. Higgins,  David V. Pilcher, et al Am J Respir Crit Care Med 2022 Dec 1;206(11):1353-1360. doi: 10.1164/rccm.202203-0539OC. Abstract Rationale: Women have worse outcomes than men in several conditions more common in men, including cardiac surgery and burns. Objectives: To describe the relationship between sex balance within each diagnost...

Research Christmas 2022: Physical Digital disparities among healthcare workers in typing speed between generations, genders, and medical specialties: cross sectional study Alex R Schuurman, M E Baarsma, W Joost Wiersinga, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072784 (Published 19 December 2022)Cite this as: BMJ 2022;379:e072784 Abstract Objective To investigate the typing skills of healthcare professionals. Design Cross...

Research Christmas 2022: Don’t Believe the Hype Everything causes cancer? Beliefs and attitudes towards cancer prevention among anti-vaxxers, flat earthers, and reptilian conspiracists: online cross sectional survey Sonia Paytubi, Yolanda Benavente, Alexandra Montoliu, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072561 (Published 21 December 2022)Cite this as: BMJ 2022;379:e072561 Abstract Objective To evaluate, using an online non-p...

ORIGINAL ARTICLE VV116 versus Nirmatrelvir–Ritonavir for Oral Treatment of Covid-19 Zhujun Cao, Weiyi Gao, Hong Bao, et al N Engl J Med December 28, 2022DOI: 10.1056/NEJMoa2208822 Abstract BACKGROUND Nirmatrelvir–ritonavir has been authorized for emergency use by many countries for the treatment of coronavirus disease 2019 (Covid-19). However, the supply falls short of the global demand, which creates a need for more options. VV116 is an oral antiviral a...

ARTICLES|ONLINE FIRST Prognostic factors associated with mortality among patients receiving venovenous extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis Alexandre Tran, Shannon M Fernando, Bram Rochwerg, et al. Lancet Respir Med Published:October 10, 2022DOI:https://doi.org/10.1016/S2213-2600(22)00296-X Summary Background Venovenous extracorporeal membrane oxygenation (ECMO) can be considered for patients with COVID-...

Research Christmas 2022: Physical Alcohol related disorders among elite male football players in Sweden: nationwide cohort study Peter Ueda, Björn Pasternak, Henrik Svanström, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-074093 (Published 21 December 2022)Cite this as: BMJ 2022;379:e074093 Abstract Objectives To assess whether male elite football players are at increased risk of alcohol related disorders compared with men from the gen...

Endotypes of Traumatic Brain Injury Traumatic brain injury (TBI) is a heterogeneous disease. It has various injury mechanisms and tissue pathologies. It is a leading cause of mortality and morbidity in young individuals globally. In addition, the incidence of TBI in older patients is an area of concern with an increase in an ageing population that is more likely to be multi-morbid and fall-prone.  Mortality from TBI has decreased over the years. How...

Research Christmas 2022: Don’t Believe the Hype Can artificial intelligence pass the Fellowship of the Royal College of Radiologists examination? Multi-reader diagnostic accuracy study Susan Cheng Shelmerdine, Helena Martin, Kapil Shirodkar, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-072826 (Published 21 December 2022)Cite this as: BMJ 2022;379:e072826 Abstract Objective To determine whether an artificial intelligence candidate coul...