ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalImpact of renal-replacement therapy strategies on outcomes for patients with chronic kidney disease: a secondary analysis of the STARRT-AKI trialBagshaw S.M. et al.OPEN ACCESS ~ OriginalModel-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients: a multicentre randomised clinical trialEwoldt T.M.J. et al.Impact of BMI on outcomes in respiratory ECMO: an ELSO registry study...

Original Investigation  November 30, 2022 Association Between Hemorrhage Control Interventions and Mortality in US Trauma Patients With Hemodynamically Unstable Pelvic Fractures Tanya Anand, Khaled El-Qawaqzeh, Adam Nelson, et al JAMA Surg. Published online November 30, 2022. doi:10.1001/jamasurg.2022.5772 Question  What is the current variation in nationwide practices for the management of pelvic fracture–related hemorrhage? Fin...

ICU Management & Practice, Volume 22 - Issue 3, 2022 Perioperative Haemodynamic Optimisation of the High-Risk Surgical Patient An overview of evidence supporting perioperative haemodynamic optimisation in high-risk surgery patients and strategies to facilitate its implementation and adoption to improve patient outcomes. A million surgical procedures performed every year worldwide are at risk of complications that can be attributed to the nature of the su...

Research Letter  November 28, 2022 Analysis of Failure Rates for COVID-19 Entrance Screening at a US Academic Medical Center Scott C. Roberts, Ridwan N. Faruq, Anne K. Wilkinson, et al JAMA Intern Med. Published online November 28, 2022. doi:10.1001/jamainternmed.2022.5426 Many health care facilities use entrance screening to prevent individuals with acute COVID-19 from entering. In ambulatory settings, 1 study found failures (defined as an e...

Editorials Oxygen administration during general anaesthesia for surgery Michele Samaja, Davide Chiumello BMJ 2022; 379 doi: https://doi.org/10.1136/bmj.o2823 (Published 30 November 2022)Cite this as: BMJ 2022;379:o2823 Oxygen can be a double edged sword Oxygen is routinely administered to almost all patients undergoing general anaesthesia,1 to ensure adequate oxygenation from intubation until awakening—the period when complications due to hypoxaemia ar...

ICU Management & Practice, Volume 22 - Issue 3, 2022 Analgesia, Sedation and Neuromuscular Blockade in Critically Ill Patients A Practical Approach for Intensivists A practical approach to analgesia, sedation and neuromuscular blockade of critically ill patients and a discussion on potential benefits, adverse effects and current professional international recommendations. Introduction Patients hospitalised in the Intensive Care Unit (ICU) are natur...

β-Lactam–Resistant Streptococcus pneumoniae Dynamics Following Treatment: A Dose-Response Meta-analysis  Matas Griskaitis,  Luis Furuya-Kanamori,  Kasim Allel,  et al Clinical Infectious Diseases, Volume 75, Issue 11, 1 December 2022, Pages 1962–1970, https://doi.org/10.1093/cid/ciac293 Abstract Background Patient exposure to antibiotics promotes the emergence of drug-resistant pathogens. The aim of this study was to identify whether the temporal dynamics o...

Research Oxygen administration during surgery and postoperative organ injury: observational cohort study David R McIlroy, Matthew S Shotwell, Marcos G Lopez, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-070941 (Published 30 November 2022)Cite this as: BMJ 2022;379:e070941 Abstract Objective To examine whether supraphysiological oxygen administration during surgery is associated with lower or higher postoperative kidney, heart, and lung inj...

Endgames Christmas 2022: Brain Stew Misspelling of antimicrobials by healthcare professionals Daniel Weiand, Joanna Lumb BMJ 2022; 379 doi: https://doi.org/10.1136/bmj.o2946 (Published 19 December 2022)Cite this as: BMJ 2022;379:o2946 Although electronic health records have widely reduced medication errors, and computerised hospital orders are an undeniable step-up in clarity from illegible handwritten orders,1234 they are not a patient safety panace...

The Influence of COVID-19 on Intensivist Wellbeing The COVID-19 pandemic has been challenging for healthcare systems around the world. In particular, the pandemic has resulted in critical care staffing shortages and has affected the quality of care.  In this review, the researchers examine the emergency response of hospitals to the pandemic and how it influenced the well-being of frontline intensivists. They also discuss potential strategies to improve inte...