ORIGINAL ARTICLE Efanesoctocog Alfa Prophylaxis for Patients with Severe Hemophilia A Annette von Drygalski, Pratima Chowdary, Roshni Kulkarni, et al N Engl J Med 2023; 388:310-318DOI: 10.1056/NEJMoa2209226 Abstract BACKGROUND Efanesoctocog alfa provides high sustained factor VIII activity by overcoming the von Willebrand factor–imposed half-life ceiling. The efficacy, safety, and pharmacokinetics of efanesoctocog alfa for prophylaxis and treatment of bl...

COMMENT|ONLINE FIRST COVID-19 infection, reinfection, and the transition to endemicity Cheryl Cohen, Juliet Pulliam Lancet Published: February 16, 2023 DOI:https://doi.org/10.1016/S0140-6736(22)02634-4 Understanding the protection conferred by previous infection against repeat infection, illness, and severe disease is key to projecting the future epidemiology of COVID-19 and to guiding vaccine policy decisions. In The Lancet, The COVID-19 Forecasting Team1 ...

ORIGINAL ARTICLE Cystatin C–Based Equation to Estimate GFR without the Inclusion of Race and Sex Hans Pottel, Jonas Björk, Andrew D. Rule, et al N Engl J Med 2023; 388:333-343DOI: 10.1056/NEJMoa2203769 Abstract BACKGROUND The accuracy of estimation of kidney function with the use of routine metabolic tests, such as measurement of the serum creatinine level, has been controversial. The European Kidney Function Consortium (EKFC) developed a creatinine-base...

ARTICLES|ONLINE FIRST Past SARS-CoV-2 infection protection against re-infection: a systematic review and meta-analysis COVID-19 Forecasting Team Lancet Published: February 16, 2023 DOI:https://doi.org/10.1016/S0140-6736(22)02465-5 Summary Background Understanding the level and characteristics of protection from past SARS-CoV-2 infection against subsequent re-infection, symptomatic COVID-19 disease, and severe disease is essential for predicting future...

Medical News in Brief  February 8, 2023 Updated COVID-19 Guidance for People Who Are Immunocompromised Emily Harris JAMA. Published online February 8, 2023. doi:10.1001/jama.2023.1176 In late January, the US Food and Drug Administration announced that Evusheld (the combined monoclonal antibodies tixagevimab and cilgavimab) is not currently authorized for emergency use because it’s likely ineffective against more than 90% o...

REVIEW| VOLUME 10, ISSUE 12, P1178-1188, DECEMBER 01, 2022 Respiratory system mechanics, gas exchange, and outcomes in mechanically ventilated patients with COVID-19-related acute respiratory distress syndrome: a systematic review and meta-analysis Mallikarjuna Ponnapa Reddy, Ashwin Subramaniam, Clara ChuaRyan Ruiyang Ling et al. Lancet Respir Med 2022; 10: 1178-1188 Published:November 03, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00393-9 ...

Viewpoint  January 20, 2023 The Importance of Shifting Sepsis Quality Measures From Processes to Outcomes Michael Klompas, Chanu Rhee, Mervyn Singer JAMA. Published online January 20, 2023. doi:10.1001/jama.2023.0340 Sepsis continues to be a leading cause of death and disability worldwide. In the US alone, more than a quarter million adults hospitalized with sepsis die each year. Clinicians, patients, regulators, and quality improvement advoc...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES EditorialIntensive Care Medicine facing the futureCiterio G. OriginalCircular material flow in the intensive care unit—environmental effects and identification of hotspotsHunfeld N. et al. Association between acute disease severity and one-year quality of life among post-hospitalisation COVID-19 patients: Coalition VII prospective cohort studyRosa R.G. et al. Relationship between immunosuppression and intensive car...

Ten Areas to Help Retain Critical Care Nurses The shortage of nurses in the ICU has been a problem for several years. However, the issue has become an even bigger problem because of the COVID-19 pandemic. Some of the most common reasons driving critical care nurses to leave include excessive workload, distress, and burnout. A shortage of nurses will likely impact the quality of patient care and quality-of-work life for all ICU staff. Hospital managers, nurse leader...

EDITORIAL Thromboprophylaxis after Extremity Fracture — Time for Aspirin? Matthew Costa N Engl J Med 2023; 388:274-275DOI: 10.1056/NEJMe2214045 Hospital-acquired venous thromboembolism remains a common and preventable cause of death, so many health care systems around the world mandate that all patients who are admitted to the hospital undergo a risk assessment for venous thromboembolism.1,2 Patients who have had traumatic injuries are at particular risk ...