Editorial  November 28, 2022 Autoimmune Encephalitis—Misdiagnosis, Misconceptions, and How to Avoid Them Josep Dalmau, Francesc Graus JAMA Neurol. Published online November 28, 2022. doi:10.1001/jamaneurol.2022.4154 The autoimmune encephalitides (AEs) are a group of immune-mediated brain diseases that frequently associate with pathogenic antibodies against neuronal or glial proteins. There are now more than 20 AEs described that individually ...

Original Investigation  September 19, 2022 Efficacy and Safety of Rituximab for New-Onset Generalized Myasthenia Gravis: The RINOMAX Randomized Clinical Trial Fredrik Piehl, Ann Eriksson-Dufva, Anna Budzianowska, et al JAMA Neurol. 2022;79(11):1105-1112. doi:10.1001/jamaneurol.2022.2887 Key Points Question  Is a single infusion with rituximab associated with greater probability of having minimal disease manifestations at 4 months in recent...

Invited Commentary  November 30, 2022 Nationwide Variation of Care for Patients With Bleeding Pelvic Fracture—An Opportunity to Rescue Better? Lydia R. Maurer, Haytham M. Kaafarani JAMA Surg. Published online November 30, 2022. doi:10.1001/jamasurg.2022.5778 Most studies in the trauma literature have examined the mortality of all patients with pelvic fractures, estimating it at around 10%.1,2 In this nationwide study, Anand and colleagues3&nb...

Original Investigation  November 28, 2022 Autoimmune Encephalitis Misdiagnosis in Adults Eoin P. Flanagan, Michael D. Geschwind, A. Sebastian Lopez-Chiriboga, et al JAMA Neurol. Published online November 28, 2022. doi:10.1001/jamaneurol.2022.4251 Question  What diseases are misdiagnosed as autoimmune encephalitis and which factors contribute to misdiagnosis? Findings  In this case series of 107 outpatients misdiagnosed ...

Original Investigation  November 2, 2022 Electroacupuncture vs Sham Electroacupuncture in the Treatment of Postoperative Ileus After Laparoscopic Surgery for Colorectal Cancer: A Multicenter, Randomized Clinical Trial Yu Wang, Jing-Wen Yang, Shi-Yan Yan, et al JAMA Surg. Published online November 2, 2022. doi:10.1001/jamasurg.2022.5674 Key Points Question  In the current medical practice adopting the Enhanced Recovery After Surge...

Reversing Sepsis-Induced Hypotension Sepsis is characterised by hypovolaemia and vasodilation. It is also characterised by organ dysfunction secondary to a dysregulated immune response of the host to the microbial pathogen. Prompt identification, early treatment with appropriate antibiotics, and fluid resuscitation can improve patient outcomes. Patients with cirrhosis and sepsis are a distinct group. The haemodynamic alterations are more profound in these patients ...

Editor's Note  November 28, 2022 The Uncertain Effects of Surveillance Screening for COVID-19 for Individuals Entering Health Care Facilities Eric Ward, Mitchell H. Katz JAMA Intern Med. Published online November 28, 2022. doi:10.1001/jamainternmed.2022.5429 Entrance surveillance screenings have been widely implemented in health care settings during the COVID-19 pandemic. These measures, which are required by the US Department of Labor,1 ...

RTICLES|ONLINE FIRST Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial Christopher C Butler, F D Richard Hobbs, Oghenekome A Gbinigie, et al Lancet AccessPublished:December 22, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)02597-1 Summary Background The safety, effectiveness, and cost-effective...

ICU Management & Practice, Volume 22 - Issue 3, 2022 Pain Management in Paediatric Critical Care An overview of the main treatment options currently available in paediatric critical care setting. Critically ill paediatric patients often suffer from pain secondary to trauma, complex medical procedures, invasive testing monitoring devices and illness-induced discomfort. Although the gold standard for assessing patient comfort is self-report, in paediatrics...

Original Investigation  September 21, 2022 Operative vs Nonoperative Treatment of Acute Unstable Chest Wall Injuries: A Randomized Clinical Trial Niloofar Dehghan, Aaron Nauth, Emil Schemitsch, et al JAMA Surg. 2022;157(11):983-990. doi:10.1001/jamasurg.2022.4299 Question  Does surgical treatment of unstable chest wall injuries improve ventilator-free days and outcomes compared to nonoperative treatment? Findings  In this randomi...