ARTICLES| VOLUME 11, ISSUE 1, P87-96, JANUARY 01, 2023 Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study Joshua J Solomon, Sonye K Danoff, Felix A Woodhead, et al. Lancet Respir Med 2023; 11: 87-96 Published:September 05, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00260-0 Summary Background Inters...

Research Long covid outcomes at one year after mild SARS-CoV-2 infection: nationwide cohort study Barak Mizrahi, Tamar Sudry, Natalie Flaks-Manov, et al BMJ 2023; 380 doi: https://doi.org/10.1136/bmj-2022-072529 (Published 11 January 2023)Cite this as: BMJ 2023;380:e072529 Abstract Objectives To determine the clinical sequelae of long covid for a year after infection in patients with mild disease and to evaluate its association with age, sex, SARS-CoV-...

Antibiotic Review Kit for Hospitals Antibiotic overuse is a growing problem in healthcare. Antimicrobial resistance has a significant impact on global public health, and its effects are similar to that of malaria and HIV. Antimicrobial resistance caused nearly 4.95 million deaths in 2019. In addition, antimicrobial resistance has significant economic consequences on healthcare systems.  Human antibiotic consumption is the primary cause of antimicrobial resi...

ARTICLES| VOLUME 11, ISSUE 1, P45-54, JANUARY 01, 2023 Rituximab versus intravenous cyclophosphamide in patients with connective tissue disease-associated interstitial lung disease in the UK (RECITAL): a double-blind, double-dummy, randomised, controlled, phase 2b trial Toby M Maher, Veronica A Tudor, Peter Saunders, et al. Lancet Respir Med 2023; 11: 45-54 Open Access Published: November 11, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00359-...

ICU是救治重症患者的主战场，但我国重症医疗资源紧缺。应用机器人、深度学习、大数据等技术研发重症监护机器人有其临床价值，可以降低医护工作强度、减少感染风险、提升医疗质量。 基于以上，北京积水潭医院联合合肥工业大学、水木东方医用机器人技术创新公司等9家单位，联合开展“国家重点研发计划-巡诊查房智能化机器人研发”项目，目前机器人可能具备生理监测、病情评估、互动式查体、远程操控、情感陪护等功能。为进一步明确全国范围内各医院ICU的临床痛点及主要临床需求，指导医工研发，现拟邀请您完成以下...

ARTICLES| VOLUME 5, ISSUE 1, E36-E46, JANUARY 01, 2023 Four SARS-CoV-2 vaccine doses or hybrid immunity in patients on immunosuppressive therapies: a Norwegian cohort study Kristin H Bjørlykke, Hilde S Ørbo, Anne T Tveter, et al. Lancet Rheumatol 2023; 5: E36-E46 Published:November 16, 2022 DOI:https://doi.org/10.1016/S2665-9913(22)00330-7 Summary Background Data on response and safety of repeated vaccinations and hybrid immunity in pat...

ORIGINAL ARTICLE Methylprednisolone for Heart Surgery in Infants — A Randomized, Controlled Trial Kevin D. Hill, Prince J. Kannankeril, Jeffrey P. Jacobs, et al N Engl J Med 2022; 387:2138-2149DOI: 10.1056/NEJMoa2212667 Abstract BACKGROUND Although perioperative prophylactic glucocorticoids have been used for decades, whether they improve outcomes in infants after heart surgery with cardiopulmonary bypass is unknown. METHODS We conducted a multicen...

CORRESPONDENCE| VOLUME 22, ISSUE 12, P1666-1668, DECEMBER 01, 2022 Resistance of SARS-CoV-2 omicron subvariant BA.4.6 to antibody neutralisation Qian Wang, Zhiteng Li, Jerren Ho, et al Lancet Infect Dis 2022; 22: 1666-1668 SARS-CoV-2, the causative agent of the COVID-19 pandemic, continues to evolve. A subvariant of SARS-CoV-2 omicron (B.1.1.529), known as BA.4.6, emerged in March, 2022, and it appears to be expanding its coverage even in the pr...

Prehospital Bundle of Care Associated With Mortality Decrease in Septic Shock Over 50 million people worldwide suffer from sepsis every year. Sepsis causes nearly 11 million deaths and is responsible for one-third to half of all in-hospital deaths. The mortality rate for sepsis ranges from 10 to 20%. For septic shock, the most serious form of sepsis, the mortality rate can range from 50 to 60%.  Guidelines recommend early recognition, severity assessment an...

Article Published: 15 September 2022 Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus Andreas Mackensen, Fabian Müller, Dimitrios Mougiakakos, et al Nature Medicine volume 28, pages 2124–2132 (2022) Abstract Systemic lupus erythematosus (SLE) is a life-threatening autoimmune disease characterized by adaptive immune system activation, formation of double-stranded DNA autoantibodies and organ inflammation. Five patients with ...