Socioeconomic Status and Outcomes in Critical Care Socioeconomic status is a known determinant of health inequalities. However, previous studies on the impact of socioeconomic status on outcomes in critical care have produced inconsistent findings.  A new review analyses available evidence on the relationship between socioeconomic status and outcomes in critical care. The analysis included observational cohort studies of adults that examined the association...

ARTICLES|ONLINE FIRST Low versus standard calorie and protein feeding in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group trial (NUTRIREA-3) Jean Reignier, Gaetan Plantefeve, Jean-Paul Mira, et al Lancet Respir Med Published:March 20, 2023 DOI:https://doi.org/10.1016/S2213-2600(23)00092-9 Summary Background The optimal calorie and protein intakes at the acute phase of severe critical illness remain unknow...

Antioxidant, Anti-inflammatory Therapy in Sepsis Sepsis is associated with long-term cognitive impairment and poor psychological and functional outcomes. Potential mechanisms for this include intracerebral oxidative stress and inflammation. However, there is limited knowledge about the effects of early antioxidant and anti-inflammatory therapy on cognitive, psychological, and functional outcomes in sepsis survivors. The Vitamin C, Thiamine, and Steroids in Sepsi...

ORIGINAL ARTICLE Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia Floor L.F. van Baarle, Emma K. van de Weerdt, Walter J.F.M. van der Velden, et al N Engl J Med 2023; 388:1956-1965DOI: 10.1056/NEJMoa2214322 Abstract BACKGROUND Transfusion guidelines regarding platelet-count thresholds before the placement of a central venous catheter (CVC) offer conflicting recommendations because of a lack of good-quality evidence. The routine...

ARTICLES|ONLINE FIRST Measuring the global response to antimicrobial resistance, 2020–21: a systematic governance analysis of 114 countries Jay Patel, Anne Harant, Genevie Fernandes, et al Lancet Infect Dis Published:January 16, 2023 DOI:https://doi.org/10.1016/S1473-3099(22)00796-4 Summary Background Understanding strategic commitments and policy responses to overcome antimicrobial resistance at the national, regional, and global levels is required t...

COMMENT|ONLINE FIRST Too many antibiotics for patients with COVID-19 despite low bacterial infections Daniele Roberto Giacobbe, Matteo Bassetti Lancet Infect Dis Published:January 27, 2023 DOI:https://doi.org/10.1016/S1473-3099(22)00866-0 Although low rates of bacterial infections have frequently been reported in patients hospitalised with COVID-19, excessive use of antibiotics has also been described in this population since the beginning of the COVID-19 p...

European Guidelines: Management of Bleeding, Coagulopathy Following Trauma According to the Global Burden of Diseases, Injuries, and Risk Factors Study, trauma accounted for 8% of total deaths annually. Among adolescents aged 10-24 years, road injuries, self-harm, and interpersonal violence are the top causes of disability-adjusted life-years, and road injuries are ranked first in the 25-49 year age group. Post-traumatic bleeding and associated traumatic coagulopat...

ARTICLES|ONLINE FIRST Incidence of infection with multidrug-resistant Gram-negative bacteria and vancomycin-resistant enterococci in carriers: a systematic review and meta-regression analysis Roel P J Willems, Karin van Dijk, Maria J G T Vehreschild, et al Lancet Infect Dis Published:January 30, 2023 DOI:https://doi.org/10.1016/S1473-3099(22)00811-8 Summary Background Carriers of multidrug-resistant bacteria are at risk of infections with these bacter...

ARTICLES|ONLINE FIRST Efficacy and safety of antimicrobial stewardship prospective audit and feedback in patients hospitalised with COVID-19 (COVASP): a pragmatic, cluster-randomised, non-inferiority trial Justin Z Chen, Holly L Hoang, Maryna Yaskina, et al Lancet Infect Dis Published:January 27, 2023 DOI:https://doi.org/10.1016/S1473-3099(22)00832-5 Summary Background The COVID-19 pandemic has been associated with increased antimicrobial use despite ...

ARTICLES|ONLINE FIRST Guideline adherence and survival of patients with candidaemia in Europe: results from the ECMM Candida III multinational European observational cohort study Martin Hoenigl, Jon Salmanton-García, Matthias Egger, et al Lancet Infect Dis Published:February 15, 2023 DOI:https://doi.org/10.1016/S1473-3099(22)00872-6 Summary Background The European Confederation of Medical Mycology (ECMM) collected data on epidemiology, risk ...