ARTICLES| VOLUME 4, ISSUE 3, E179-E191, MARCH 2023 Antimicrobial resistance in patients with COVID-19: a systematic review and meta-analysis Bradley J Langford, Miranda So, Marina Simeonova, et al Lancet Microbe Published:January 31, 2023 DOI:https://doi.org/10.1016/S2666-5247(22)00355-X Summary Background Frequent use of antibiotics in patients with COVID-19 threatens to exacerbate antimicrobial resistance. We aimed to establish the pr...

World Sepsis Day The Global Sepsis Alliance (GSA) and the Sepsis Stiftung joined together to celebrate 10 years of World Sepsis Day on 16 September 2022 in Berlin, under the theme of " Making Sepsis a National and Global Health Priority”. The event aimed to engage with high-level policy makers, representatives of health authorities, patient organizations, health care providers, science, industry, and civil society, to learn from each other through networking a...

ARTICLES| VOLUME 4, ISSUE 3, E159-E170, MARCH 2023 Global epidemiology and clinical outcomes of carbapenem-resistant Pseudomonas aeruginosa and associated carbapenemases (POP): a prospective cohort study Jinnethe Reyes, Lauren Komarow, Liang Chen, et al. Lancet Microbe 2023; 4: E159-E170 Published: February 09, 2023 DOI:https://doi.org/10.1016/S2666-5247(22)00329-9 Summary Background Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a gl...

ARTICLES|ONLINE FIRST Real-world use of nirmatrelvir–ritonavir in outpatients with COVID-19 during the era of omicron variants including BA.4 and BA.5 in Colorado, USA: a retrospective cohort study Neil R Aggarwal, Kyle C Molina, Laurel E Beaty, et al. Lancet Infect Dis Published: February 10, 2023 DOI:https://doi.org/10.1016/S1473-3099(23)00011-7 Summary Background Nirmatrelvir is a protease inhibitor with in-vitro activity against SARS-CoV-2, and ri...

New Paradigm of Personalised Sedation Lung-protective ventilation (LPV) limits lung injury (VILI). However, deep sedation is required to tolerate LPV, and patient self-induced lung injury (P-SILI) can occur during spontaneous breathing along with high respiratory efforts, lung stress and strain. Prevention of P-SILI may require further sedation. In addition, patient-ventilator dyssynchrony can worsen outcomes, resulting in increased sedation.  Ventilation t...

ARTICLES|ONLINE FIRST Guideline adherence and survival of patients with candidaemia in Europe: results from the ECMM Candida III multinational European observational cohort study Martin Hoenigl, Jon Salmanton-García, Matthias Egger, et al Lancet Infect Dis Published: February 15, 2023 DOI:https://doi.org/10.1016/S1473-3099(22)00872-6 Summary Background The European Confederation of Medical Mycology (ECMM) collected data on epidemiology, risk factors, ...

Editor's Note  February 20, 2023 At a Higher Dose and Longer Duration, Ivermectin Still Not Effective Against COVID-19 Kirsten Bibbins-Domingo, Preeti N. Malani JAMA. Published online February 20, 2023. doi:10.1001/jama.2023.1922 ACochrane meta-analysis of 11 eligible trials examining the efficacy of ivermectin for the treatment of COVID-19 published through April 2022 concluded that ivermectin has no beneficial effect for people with COVID-1...

CORRESPONDENCE|ONLINE FIRST Infection rate in Guangzhou after easing the zero-COVID policy: seroprevalence results to ORF8 antigen Junyuan Huang, Shi Zhao, Ka Chun Chong, et al. Lancet Infect Dis Published: February 17, 2023 DOI:https://doi.org/10.1016/S1473-3099(23)00112-3 On Dec 7, 2022, the Chinese government announced ten measures indicating the end of the zero-COVID policy, which was in effect for more than 2 years.1 Most of the stringent preventive me...

Speed of Cooling After Cardiac Arrest: Sub-study from TTM-2 Trial Out-of-hospital cardiac arrest (OHCA) typically has a poor prognosis. Less than 50% of patients admitted to ICU survive to hospital discharge. Animal models suggest that therapeutic hypothermia is neuroprotective and decreases neuronal injury.  Targeted temperature management (TTM 33–36 °C) is part of international guidelines when managing post-OHCA patients. Evidence suggests that better neu...

於服用口服抗病毒藥的新冠病毒住院患者中，病毒量反彈的風險因素及相關臨床結果: 一項 回顧性隊列研究 ARTICLES|ONLINE FIRST Viral burden rebound in hospitalised patients with COVID-19 receiving oral antivirals in Hong Kong: a population-wide retrospective cohort study Carlos K H Wong, Kristy T K Lau, Ivan C H Au, et al. Lancet Infect Dis Published: February 13, 2023 DOI:https://doi.org/10.1016/S1473-3099(22)00873-8 Summary Background Viral rebound after ...