Research Inequities in surgical outcomes by race and sex in the United States: retrospective cohort study Dan P Ly, Mariah B Blegen, Melinda M Gibbons, et al BMJ 2023; 380 doi: https://doi.org/10.1136/bmj-2022-073290 (Published 01 March 2023)Cite this as: BMJ 2023;380:e073290 Abstract Objective To assess inequities in mortality by race and sex for eight common surgical procedures (elective and non-elective) across specialties in the United States. D...

COMMENT|ONLINE FIRST Remdesivir saves lives. Were 3 years needed to learn that? Andre C Kalil Lancet Respir Med Published: February 21, 2023 DOI:https://doi.org/10.1016/S2213-2600(23)00036-X In The Lancet Respiratory Medicine, Alain Amstutz and colleagues1address a 3-year-old controversy: does remdesivir reduce mortality in patients hospitalised for COVID-19? Remdesivir is a viral RNA polymerase inhibitor that was evaluated in patients hospitalised for C...

Impact of Fatigue on Anaesthesia Providers Fatigue is being recognised as a workplace hazard of increasing concern. It is a significant problem for anaesthesiologists who have long working hours and irregular schedules. Fatigue negatively impacts vigilance, communication, and teamwork and shows decreased performance during psychomotor testing. However, its impact on real-life performance is uncertain. Fatigue is a complex issue with many definitions proposed in ...

ARTICLES|ONLINE FIRST Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study Samuel Channon-Wells, Ortensia Vito, Andrew J McArdle, et al. Lancet Rheumatol Published:February 14, 2023 DOI:https://doi.org/10.1016/S2665-9913(23)00029-2 Summary Background Multisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory condition associated with SARS-CoV-2 infe...

COMMENT|ONLINE FIRST Real-world effectiveness of nirmatrelvir–ritonavir against BA.4 and BA.5 omicron SARS-CoV-2 variants Carlos K H Wong, Kristy T K Lau, Gabriel M Leung Lancet Infect Dis Published: February 10, 2023 DOI:https://doi.org/10.1016/S1473-3099(23)00056-7 Over the past year of the COVID-19 pandemic, populations worldwide have been facing the constant threat of the SARS-CoV-2 omicron variant and its sublineages, and the high transmissibility and ...

ARTICLES|ONLINE FIRST Long-term effectiveness of COVID-19 vaccines against infections, hospitalisations, and mortality in adults: findings from a rapid living systematic evidence synthesis and meta-analysis up to December, 2022 Nana Wu, Keven Joyal-Desmarais, Paula A B Ribeiro, et al. Lancet Respir Med Published: February 10, 2023 DOI:https://doi.org/10.1016/S2213-2600(23)00015-2 Summary Background Synthesising evidence on the long-term vaccine effect...

Shifting Sepsis Quality Measures From Processes to Outcomes Sepsis is a significant health issue that leads to high rates of death and disability, with over 250,000 adult deaths annually in the U.S. alone. Healthcare providers, patients, regulatory agencies, and advocates for quality improvement acknowledge the importance of preventing sepsis and improving its outcomes.  The Severe Sepsis/Septic Shock Early Management Bundle (SEP-1) from the Centers for Med...

ARTICLES|ONLINE FIRST Effects of remdesivir in patients hospitalised with COVID-19: a systematic review and individual patient data meta-analysis of randomised controlled trials Alain Amstutz, Benjamin Speich, France Mentré, et al. Lancet Respir Med Published:February 21, 2023 DOI:https://doi.org/10.1016/S2213-2600(22)00528-8 Summary Background Interpretation of the evidence from randomised controlled trials (RCTs) of remdesivir in patients treated in...

ARTICLES|ONLINE FIRST Efficacy of SARS-CoV-2 vaccines and the dose–response relationship with three major antibodies: a systematic review and meta-analysis of randomised controlled trials Zhi-Rong Yang, Yi-Wen Jiang, Fu-Xiao Li, et al. Lancet Microbe Published: February 28, 2023 DOI:https://doi.org/10.1016/S2666-5247(22)00390-1 Summary Background The efficacy of SARS-CoV-2 vaccines in preventing severe COVID-19 illness and death is uncertain due to th...

COMMENT|ONLINE FIRST SARS-CoV-2 rebound with and without antivirals Nicola Petrosillo Lancet Infect Dis Published: February 13, 2023 DOI:https://doi.org/10.1016/S1473-3099(23)00063-4 As the COVID-19 pandemic continues, interventions for preventing SARS-CoV-2 transmission and progression to severe disease remain priorities. Vaccines against COVID-19 have an important role in preventing symptomatic infections that would otherwise lead to hospitalisation and d...