Guidelines Open Access Published: 01 March 2023 The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition Rolf Rossaint, Arash Afshari, Bertil Bouillon, et al Crit Care 2023; 27: 80 I. Initial resuscitation and prevention of further bleeding Minimal elapsed time Recommendation 1 We recommend that severely injured patients be transported directly to an appropriate trauma facility (Grade 1B...

Research Comparison of mental health symptoms before and during the covid-19 pandemic: evidence from a systematic review and meta-analysis of 134 cohorts Ying Sun, Yin Wu, Suiqiong Fan, et al BMJ 2023; 380 doi: https://doi.org/10.1136/bmj-2022-074224 (Published 08 March 2023)Cite this as: BMJ 2023;380:e074224 Abstract Objective To synthesise results of mental health outcomes in cohorts before and during the covid-19 pandemic. Design Systematic ...

Measuring Global Response to Antimicrobial Resistance In order to evaluate current progress and future planning to overcome antimicrobial resistance, it is important to understand strategic commitments and policy responses. The most important mechanism guiding national strategy and action for antimicrobial resistance governance is the national action plans (NAPs). Several NAPs have been developed, but to date, there has been no comprehensive analysis of these plans...

Research Molnupiravir and risk of hospital admission or death in adults with covid-19: emulation of a randomized target trial using electronic health records Yan Xie, Benjamin Bowe, Ziyad Al-Aly BMJ 2023; 380 doi: https://doi.org/10.1136/bmj-2022-072705 (Published 07 March 2023)Cite this as: BMJ 2023;380:e072705 Abstract Objective To emulate a randomized target trial to estimate the association between the antiviral drug molnupiravir and hospital admis...

ARTICLES|ONLINE FIRST Early childhood lower respiratory tract infection and premature adult death from respiratory disease in Great Britain: a national birth cohort study James Peter Allinson, Nishi Chaturvedi, Andrew Wong, et al. Lancet Published:March 07, 2023 DOI:https://doi.org/10.1016/S0140-6736(23)00131-9 Summary Background Lower respiratory tract infections (LRTIs) in early childhood are known to influence lung development and lifelong lung hea...

EDITORIAL Continued Progress in Therapy for Pulmonary Arterial Hypertension Darren B. Taichman, Jane A. Leopold, Greg Elliott N Engl J Med March 6, 2023DOI: 10.1056/NEJMe2300324 Pulmonary arterial hypertension is a devastating disorder characterized by precapillary pulmonary hypertension not caused by respiratory disease, obstruction of the pulmonary arteries, or certain less-common conditions. Idiopathic pulmonary arterial hypertension, heritable pulmonary ar...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalDaily point-of-care ultrasound-assessment of central venous catheter-related thrombosis in critically ill patients: a prospective multicenter studyWu C. et al. OPEN ACCESSOptimal oxygen and mean arterial blood pressure targets after cardiac arrestSkrifvars M., Bray J. and Hassager C. Understanding the DiseaseHigh-risk pulmonary embolism in the intensive care unitHelms J., Carrier M. and Klok F.A. Recent adv...

ORIGINAL ARTICLE Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension Marius M. Hoeper, David B. Badesch, H. Ardeschir Ghofrani, et al N Engl J Med March 6, 2023DOI: 10.1056/NEJMoa2213558 Abstract BACKGROUND Pulmonary arterial hypertension is a progressive disease involving proliferative remodeling of the pulmonary vessels. Despite therapeutic advances, the disease-associated morbidity and mortality remain high. Sotatercept is a ...

ICU Management & Practice, Volume 22 - Issue 5, 2022 Improving Haemodynamic Management of ICU Patients: Decatecholaminisation & Cardiac Stress Reduction A summary of a symposium organised by AOP Health with presentations from Ricard Ferrer, Vall d’Hebron University Hospital, Barcelona, Spain; Bruno Levy, Centre Hospitalier Universitaire de Nancy, CHU Nancy · Réanimation Médicale Brabois, France; and Michael Fries, St. Vincenz Krankenhaus Limburg, Depart...

Original Investigation  March 7, 2023 Effect of Intrapartum Azithromycin vs Placebo on Neonatal Sepsis and Death: A Randomized Clinical Trial Anna Roca, Bully Camara, Joel D. Bognini, et al JAMA. 2023;329(9):716-724. doi:10.1001/jama.2022.24388 Key Points Question  Does azithromycin administered orally during labor reduce neonatal sepsis and mortality? Findings  This randomized trial in West Africa included 11 983 bi...