ARTICLES|ONLINE FIRST Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study Tài Pham, Leo Heunks, Giacomo Bellani, et al. Lancet Respir Med Published:January 21, 2023 DOI:https://doi.org/10.1016/S2213-2600(22)00449-0 Summary Background Current management practices and outcomes in weaning from invasive mechanical ventilation are poorly understood. We aimed to ...

Research Association between healthy lifestyle and memory decline in older adults: 10 year, population based, prospective cohort study Jianping Jia, Tan Zhao, Zhaojun Liu, et al BMJ 2023; 380 doi: https://doi.org/10.1136/bmj-2022-072691 (Published 25 January 2023)Cite this as: BMJ 2023;380:e072691 Abstract Objective To identify an optimal lifestyle profile to protect against memory loss in older individuals. D...

Source Control and Sepsis Management Source control is important in the treatment of sepsis and septic shock. Lack or delay of source control can result in worse outcomes for patients.   The 2021 Surviving Sepsis Campaign guidelines recommend identifying the anatomical source of infection that requires source control and implementing it as soon as possible. However, adequate source control is difficult to define, and its optimal timing is difficult to ...

ARTICLES|ONLINE FIRST Sodium bicarbonate for kidney transplant recipients with metabolic acidosis in Switzerland: a multicentre, randomised, single-blind, placebo-controlled, phase 3 trial Nilufar Mohebbi, Alexander Ritter, Anna Wiegand, et al. Lancet Published:January 25, 2023 DOI:https://doi.org/10.1016/S0140-6736(22)02606-X Summary Background Metabolic acidosis is common in kidney transplant recipients and is associated with declining graft functi...

Closed-Loop Oxygen Control in Patients With AHRF High flow nasal oxygen (HFNO) has many physiological benefits in patients with acute hypoxaemic respiratory failure (AHRF). It can also help reduce the need for intubation. However, optimal flow settings are unknown and are generally based on expert recommendations.  Maintaining oxygenation within a given target range requires intensive patient monitoring and frequent manual adjustment of the fraction of insp...

Research Cerebral regional tissue Oxygen Saturation to Guide Oxygen Delivery in preterm neonates during immediate transition after birth (COSGOD III): multicentre randomised phase 3 clinical trial Gerhard Pichler, Katharina Goeral, Marlene Hammerl, et al BMJ 2023; 380 doi: https://doi.org/10.1136/bmj-2022-072313 (Published 24 January 2023)Cite this as: BMJ 2023;380:e072313 Abstract Objective To investigate whether monitoring of cerebral tissue oxygen s...

Feature Covid Unanswered Questions How are covid-19 symptoms changing? Mun-Keat Looi BMJ 2023; 380 doi: https://doi.org/10.1136/bmj.p3 (Published 18 January 2023)Cite this as: BMJ 2023;380:p3 With new variants and a changing landscape of vaccination and immunity, what do the symptoms of covid-19—and our understanding of them—now look like? Mun-Keat Looireports How have covid symptoms changed since the start of the pandemic? In the short space o...

Multisystem Inflammatory Syndrome in Adults: Case Finding Through Systematic Review of Electronic Medical Records  Michael Melgar,  Julia Haston,  Jennifer DeCuir,  et al Clinical Infectious Diseases, Volume 75, Issue 11, 1 December 2022, Pages 1903–1911, https://doi.org/10.1093/cid/ciac303 Abstract Background Multisystem inflammatory syndrome in adults (MIS-A) is a severe condition temporally associated with severe acute respiratory syndrome coronavir...

Editorial  January 17, 2023 TRANSFORM-HF—Can We Close the Loop on Diuretics in Heart Failure? Michelle M. Kittleson JAMA. 2023;329(3):211-213. doi:10.1001/jama.2022.21692 Fluid overload is the cardinal manifestation of heart failure, and prior to the 20th century, treatment options were limited to purgatives, bloodletting, leeching, or lancing. It was not until 1920 that the concept of a diuretic was first appreciated, when physicians observe...

ORIGINAL ARTICLE Efanesoctocog Alfa Prophylaxis for Patients with Severe Hemophilia A Annette von Drygalski, Pratima Chowdary, Roshni Kulkarni, et al N Engl J Med 2023; 388:310-318DOI: 10.1056/NEJMoa2209226 Abstract BACKGROUND Efanesoctocog alfa provides high sustained factor VIII activity by overcoming the von Willebrand factor–imposed half-life ceiling. The efficacy, safety, and pharmacokinetics of efanesoctocog alfa for prophylaxis and treatment of bl...