ARTICLES|ONLINE FIRST Favipiravir in patients hospitalised with COVID-19 (PIONEER trial): a multicentre, open-label, phase 3, randomised controlled trial of early intervention versus standard care Pallav L Shah, Christopher M Orton, Beatriz Grinsztejn, et al. Lancet Respir Med Published:December 14, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00412-X Summary Background COVID-19 has overwhelmed health services globally. Oral antiviral therapies are ...

ICU Management & Practice, Volume 22 - Issue 4, 2022 Short Acting Beta-Blockers in Critically Ill Patients With Heart Failure An overview of the clinical evidence demonstrating the effectiveness of landiolol for the treatment of atrial fibrillation or atrial flutter with heart failure and effective heart rate control during arrhythmias. Supraventricular arrhythmias (SVTs) are common in post-operative and cardiac ICUs. SVTs increase the risk of death as w...

ARTICLES|ONLINE FIRST Comparative outcomes of extracorporeal membrane oxygenation for COVID-19 delivered in experienced European centres during successive SARS-CoV-2 variant outbreaks (ECMO-SURGES): an international, multicentre, retrospective cohort study Matthieu Schmidt, David Hajage, Micha Landoll, et al. Lancet Respir Med Published:January 11, 2023 DOI:https://doi.org/10.1016/S2213-2600(22)00438-6 Summary Background To inform future research and ...

ARTICLES|ONLINE FIRST Effect of early mobilisation on long-term cognitive impairment in critical illness in the USA: a randomised controlled trial Bhakti K Patel, Krysta S Wolfe, Shruti B Patel, et al Lancet Respir Med Published:January 21, 2023 DOI:https://doi.org/10.1016/S2213-2600(22)00489-1 Summary Background Patients who have received mechanical ventilation can have prolonged cognitive impairment for which there is no known treatment. We aimed to...

Editorials Healthy lifestyles for dementia prevention Séverine Sabia, Archana Singh-Manoux BMJ 2023; 380 doi: https://doi.org/10.1136/bmj.p117 (Published 25 January 2023)Cite this as: BMJ 2023;380:p117 An increasingly urgent public health priority Ageing is accompanied by a decline in several measures of cognitive function, such as memory, reasoning, and psychomotor speed. Differences in the rate of change in cognitive function can be substantial between in...

Sex Differences in Treatment of ICU Patients Sex imbalance in the ICU has been consistently reported. Worldwide, fewer women are admitted to the ICU than men. Several studies have reported systematic differences in the treatment men and women receive in ICUs. Studies from Europe, North America, and Asia all show women are less likely to receive invasive mechanical ventilation than men. Studies also show that women have lower mean Therapeutic Intervention Scoring Sy...

ARTICLES|ONLINE FIRST Effect of non-invasive ventilation after extubation in critically ill patients with obesity in France: a multicentre, unblinded, pragmatic randomised clinical trial Audrey De Jong, Anne Bignon, François Stephan, et al. Lancet Respir Med Published:January 21, 2023 DOI:https://doi.org/10.1016/S2213-2600(22)00529-X Summary Background Non-invasive ventilation (NIV) and oxygen therapy (high-flow nasal oxygen [HFNO] or standard oxygen)...

ARTICLES|ONLINE FIRST Continued enteral nutrition until extubation compared with fasting before extubation in patients in the intensive care unit: an open-label, cluster-randomised, parallel-group, non-inferiority trial Mickaël Landais, Mai-Anh Nay, Johann Auchabie, et al. Lancet Respir Med Published:January 21, 2023 DOI:https://doi.org/10.1016/S2213-2600(22)00413-1 Summary Background Fasting is frequently imposed before extubation in patients in inte...

COMMENT|ONLINE FIRST Six pills less: no benefit for bicarbonate supplementation in renal allograft recipients Klemens Budde, Fabian Halleck Lancet Published:January 25, 2023 DOI:https://doi.org/10.1016/S0140-6736(22)02630-7 Metabolic acidosis (defined as serum bicarbonate <22 mmol/L) is frequent in patients with chronic kidney disease and is associated with disease progression.1Several prospective trials and meta-analyses2, 3, 4, 5, 6...

Nutrition Therapy and Clinical Outcomes in Critically Ill Patients Nutrition therapy is an important component of care for critically ill patients. The European Society for Clinical Nutrition and Metabolism (ESPEN) critical care guidelines recommend a progressive ramp-up of medical nutrition therapy, providing < 70% of measured energy expenditure or estimated needs during the early phase of acute illness and up to 80–100% after day three.  The clinical o...