ICU Management & Practice, Volume 23 - Issue 2, 2023 Detecting Euglycaemic Diabetic Ketoacidosis Associated With SGLT2 Inhibitors SGLT2 inhibitor associated EDKA is becoming more prevalent due to the increasing use of SGLT2 inhibitors in cardiovascular medicine and type 2 diabetes. Physician awareness and knowledge about the disease and diagnostic tools need to improve for better management. Point of care blood testing for ketones can allow for rapid and ac...

A New Global Definition of Acute Respiratory Distress Syndrome Michael A. Matthay, Yaseen Arabi, Alejandro C. Arroliga, et al Am J Respir Crit Care Med Published July 24, 2023 10.1164/rccm.202303-0558WS Abstract Background Since the 2012 Berlin Definition of the Acute Respiratory Distress Syndrome (ARDS), several developments have supported the need for an expansion of the definition, including the use of high flow nasal oxygen (HFNO), expanding use of p...

Original Investigation  February 27, 2023 Performance on Patient Experience Measures of Former Chief Medical Residents as Physician Exemplars Chosen by the Profession Lucy Chen, J. Michael McWilliams JAMA Intern Med. 2023;183(4):350-359. doi:10.1001/jamainternmed.2023.0025 Key Points Question  What can be learned about the medical profession’s ability to identify physician exemplars using the selection of chief medical residents and their ...

ICU Management & Practice, Volume 23 - Issue 3, 2023 Current Airway Management During Anaesthesia - The STARGATE Study An overview of the International obServational sTudy on AiRway manaGement in operAting room and non-operaTing room anaEsthesia (STARGATE study) that will collect information on peri-intubation adverse events and airway management procedures in adult patients undergoing general anaesthesia to receive surgery or other diagnostic/therapeutic p...

Original Investigation  June 6, 2023 Letermovir vs Valganciclovir for Prophylaxis of Cytomegalovirus in High-Risk Kidney Transplant Recipients: A Randomized Clinical Trial Ajit P. Limaye, Klemens Budde, Atul Humar, et al JAMA. 2023;330(1):33-42. doi:10.1001/jama.2023.9106 Key Points Question  Is prophylaxis with letermovir noninferior to valganiclovir for cytomegalovirus (CMV) disease prevention in high-risk CMV-seronegative kidney transpl...

Research Association between surgeon volume and patient outcomes after elective shoulder replacement surgery using data from the National Joint Registry and Hospital Episode Statistics for England: population based cohort study Epaminondas Markos Valsamis, Gary S Collins, Rafael Pinedo-Villanueva, et al BMJ 2023; 381 doi: https://doi.org/10.1136/bmj-2023-075355 (Published 21 June 2023)Cite this as: BMJ 2023;381:e075355 Abstract Objective To investigate...

Research Associations between modest reductions in kidney function and adverse outcomes in young adults: retrospective, population based cohort study Junayd Hussain, Nicholas Grubic, Ayub Akbari, et al BMJ 2023; 381 doi: https://doi.org/10.1136/bmj-2023-075062 (Published 23 June 2023)Cite this as: BMJ 2023;381:e075062 Abstract Abstract Objective To study age specific associations of modest reductions in estimated glomerular filtration rate (eGFR) wi...

Research Risk prediction of covid-19 related death or hospital admission in adults testing positive for SARS-CoV-2 infection during the omicron wave in England (QCOVID4): cohort study Julia Hippisley-Cox, Kamlesh Khunti, Aziz Sheikh, et al BMJ 2023; 381 doi: https://doi.org/10.1136/bmj-2022-072976 (Published 21 June 2023)Cite this as: BMJ 2023;381:e072976 Abstract Objectives To derive and validate risk prediction algorithms (QCOVID4) to estimate the ri...

To Mobilise or Not to Mobilise Patients who receive prolonged ventilation are at significant risk of muscle atrophy, severe weakness, long-term disability, and increased mortality. Early mobilisation has been advocated in multiple international guidelines, with widespread support from healthcare professionals. Early mobilisation is believed to have potential benefits, such as reducing the duration of mechanical ventilation, decreasing the occurrence of delirium,...

ARTICLES|ONLINE FIRST Balanced crystalloid solution versus saline in deceased donor kidney transplantation (BEST-Fluids): a pragmatic, double-blind, randomised, controlled trial Michael G Collins, Magid A Fahim, Elaine M Pascoe, et al. Lancet Published:June 18, 2023 DOI:https://doi.org/10.1016/S0140-6736(23)00642-6 Summary Background Delayed graft function (DGF) is a major adverse complication of deceased donor kidney transplantation. Intravenous flui...