ARTICLES March 21, 2026Open Access Endotracheal surfactant for infants with life-threatening bronchiolitis (BESS): a randomised, blinded, sham-controlled, phase 2 trial Malcolm G Semple, Chloe Donohue, Laura Price, et al Lancet Respir Med Published March 21, 2026 DOI: 10.1016/S2213-2600(26)00008-1 Summary Background Bronchiolitis is a common viral respiratory disease of infants, with severity ranging from mild symptoms, such as coryza and feeding diff...

Targeted Tissue Perfusion vs Macrocirculatory-Guided Standard Care in Septic Shock In Sepsis Wed, 28 Jan 2026 The TARTARE-2S trial investigated whether a haemodynamic strategy focused on improving tissue perfusion while permitting lower-than-recommended mean arterial pressure (MAP) could improve outcomes in patients with septic shock compared with conventional MAP-guided standard care. Current sepsis guidelines prioritise maintaining MAP targets, typic...

LATEST ARTICLES Original Sex, time, and disability status differences in mortality, multidimensional morbidity, and health care utilization: a secondary analysis of the Canadian RECOVER study Burns, K.E.A., Huszti, E., Li, Q. et al. Temporary mechanical support in fulminant myocarditis: prognostic factors and clinical implications from the FULLMOON study Schmidt, M., Ponnaiah, M., Huang, F. et al. Spontaneous breathing trials as predictors of extubation ...

JOURNAL ARTICLE Aspergillosis-Attributable Mortality in the United States: Analysis of Death Certificate Data Thomas J Walsh, Dakota Sicignano, Matthew Mastropietro, et al Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 86–92, https://doi.org/10.1093/cid/ciaf653 Abstract Background The nationwide attributable mortality of aspergillosis in the era of mold-active triazoles is poorly understood. Methods We ...

Suspension-Based Lower-Limb Rehabilitation for ICU-Acquired Weakness In ICU Wed, 21 Jan 2026 A recent trial evaluated the short-term efficacy of a suspension-based lower-limb rehabilitation device (SS) in patients with intensive care unit–acquired weakness (ICUAW). ICUAW is a frequent and serious complication of critical illness, characterised by symmetrical limb weakness, prolonged mechanical ventilation, functional impairment, and reduced quality of ...

Original Investigation  Infectious Diseases Incidence and Outcomes of Candida Bloodstream Infection in Solid Organ Transplant Recipients Roni Bitterman, Julianne V. Kus, Geena Verma, et al JAMA Netw Open 2026;9;(3):e261467. doi:10.1001/jamanetworkopen.2026.1467 Key Points Question  What are the incidence and outcomes of candidemia in solid organ transplant recipients (SOTRs)? Findings &n...

Original Investigation  Critical Care Medicine Incidence of Adverse Events in Peripheral Intravenous Vasopressor Use: A Systematic Review and Meta-Analysis Shang-Jun ZhangJian, Kuang-Yu Niu, Chen-Bin Chen, et al JAMA Netw Open 2026;9;(3):e260710. doi:10.1001/jamanetworkopen.2026.0710 Key Points Question  What is the incidence of adverse events (AEs) and avoidance of central venous catheter (CVC) placement...

Invasive & Non-Invasive Monitoring of Inspiratory Effort & Drive in Assisted Mechanical Ventilation In ICU Wed, 21 Jan 2026 A clinical review examined the invasive and non-invasive monitoring of inspiratory effort and respiratory drive in patients undergoing assisted mechanical ventilation (AMV). Following the acute phase of respiratory failure, AMV is commonly used to support spontaneous breathing, improve gas exchange, and reduce sedation req...

Articles Global policy responses to antimicrobial resistance, 2021–22: a systematic governance analysis of 161 countries and territories Jay Patel, Sahar Saeedi Moghaddam, Sruthi Ranganathan, et al Lancet Infect Dis 2026; 26: 55-66 https://doi.org/10.1016/S1473-3099(25)00406-2 Summary Background Most countries have endorsed a national action plan (NAP) on antimicrobial resistance. We previously used a governance framework to assess NAPs on antimicrobi...

Invited Commentary  Infectious Diseases Is It Time to Use Single-Dose Amphotericin B for HIV-Related Cryptococcal Meningitis? Nathan C. Bahr, Radha Rajasingham, David R. Boulware JAMA Netw Open 2026;9;(1):e2553489. doi:10.1001/jamanetworkopen.2025.53489 Cryptococcal meningitis remains a life-threatening opportunistic infection among people with advanced HIV, even in high-resource settings. For decades, the standard induction regimen in the United State...